EMSY 는 사람에게서 EMSY [5] 유전자 에 의해 암호화되는 단백질 이다.
임상적 의의 EMSY는 아토피 와 다감작에 [6]
상호 작용 EMSY는 ZMYND11 ,[7] BRCA2 [7] CBX1 과 [7] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000158636 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000035401 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: C11orf30 chromosome 11 open reading frame 30" .^ Amaral, A. F. S.; Minelli, C.; Guerra, S.; Wjst, M.; Probst-Hensch, N.; Pin, I.; Svanes, C.; Janson, C.; Heinrich, J.; Jarvis, D. L. (March 2015). "The locus C11orf30 increases susceptibility to poly-sensitization". Allergy . 70 (3): 328–333. doi :10.1111/all.12557 . hdl :10044/1/21574 PMID 25546184 . S2CID 25960081 . ^ a b c Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T (Nov 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer" . Cell . 115 (5): 523–35. doi :10.1016/S0092-8674(03)00930-9 PMID 14651845 . S2CID 18911371 . 외부 링크 추가 정보 Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T (2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer" . Cell . 115 (5): 523–35. doi :10.1016/S0092-8674(03)00930-9 PMID 14651845 . S2CID 18911371 . Bera TK, Das S, Maeda H, Beers R, Wolfgang CD, Kumar V, Hahn Y, Lee B, Pastan I (2004). "NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate" . Proc. Natl. Acad. Sci. U.S.A . 101 (9): 3059–64. doi :10.1073/pnas.0308746101 PMC 365744 PMID 14981236 . Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Ekblad CM, Chavali GB, Basu BP, Freund SM, Veprintsev D, Hughes-Davies L, Kouzarides T, Doherty AJ, Itzhaki LS (2005). "Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69" . EMBO Rep . 6 (7): 675–80. doi :10.1038/sj.embor.7400415 . PMC 1369107 PMID 15947784 . Chavali GB, Ekblad CM, Basu BP, Brissett NC, Veprintsev D, Hughes-Davies L, Kouzarides T, Itzhaki LS, Doherty AJ (2005). "Crystal structure of the ENT domain of human EMSY". J. Mol. Biol . 350 (5): 964–73. doi :10.1016/j.jmb.2005.05.047 . PMID 15978617 . Benusiglio PR, Lesueur F, Luccarini C, McIntosh J, Luben RN, Smith P, Dunning A, Easton DF, Ponder BA, Pharoah PD (2005). "Common variation in EMSY and risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs" . BMC Cancer . 5 : 81. doi :10.1186/1471-2407-5-81 . PMC 1185523 PMID 16029503 . Raouf A, Brown L, Vrcelj N, To K, Kwok W, Huntsman D, Eaves CJ (2005). "Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY" . J. Natl. Cancer Inst . 97 (17): 1302–6. doi :10.1093/jnci/dji254 PMID 16145051 . Brown LA, Irving J, Parker R, Kim H, Press JZ, Longacre TA, Chia S, Magliocco A, Makretsov N, Gilks B, Pollack J, Huntsman D (2006). "Amplification of EMSY, a novel oncogene on 11q13, in high grade ovarian surface epithelial carcinomas". Gynecol. Oncol . 100 (2): 264–70. doi :10.1016/j.ygyno.2005.08.026 . PMID 16236351 . Huang Y, Myers MP, Xu RM (2006). "Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding" . Structure . 14 (4): 703–12. doi :10.1016/j.str.2006.01.007 PMID 16615912 .
PDB 갤러리
1utu : 신규단백질 Emsy Truncate의 결정구조
2fmm : EMSY-HP1 복합체의 결정 구조
