보존 올리고머 골지 복합체 서브유닛 1은 COG1 [5] [6] 단백질 이다.
이 유전자에 의해 코드된 단백질은 골지 형태학과 기능에 필요한 골지 국소화 복합체(COG)를 형성하는 8개의 단백질 중 하나이다. 이 단백질은 당결합체의 정상적인 내측처리 및 트랜스골지 관련처리에 필요하며 골지 국재복합체 [6]
상호 작용 COG1은 COG4 [7] COG3 와 [8] 것 으로 나타났다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000166685 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000018661 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Chatterton JE, Hirsch D, Schwartz JJ, Bickel PE, Rosenberg RD, Lodish HF, Krieger M (Mar 1999). "Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex" . Proc Natl Acad Sci U S A . 96 (3): 915–20. Bibcode :1999PNAS...96..915C . doi :10.1073/pnas.96.3.915 PMC 15325 PMID 9927668 . ^ a b "Entrez Gene: COG1 component of oligomeric golgi complex 1" .^ Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex" . J. Biol. Chem . United States. 279 (23): 24640–8. doi :10.1074/jbc.M400662200 ISSN 0021-9258 . PMID 15047703 . ^ Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp" . J. Biol. Chem . United States. 277 (24): 21955–61. doi :10.1074/jbc.M202326200 ISSN 0021-9258 . PMID 11929878 .
추가 정보 Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (1): 65–73. doi :10.1093/dnares/7.1.65 PMID 10718198 . Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp" . J. Biol. Chem . 277 (24): 21955–61. doi :10.1074/jbc.M202326200 PMID 11929878 . Ungar D, Oka T, Brittle EE, et al. (2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function" . J. Cell Biol . 157 (3): 405–15. doi :10.1083/jcb.200202016 . PMC 2173297 PMID 11980916 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex" . J. Biol. Chem . 279 (23): 24640–8. doi :10.1074/jbc.M400662200 PMID 15047703 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ungar D, Oka T, Vasile E, et al. (2005). "Subunit architecture of the conserved oligomeric Golgi complex" . J. Biol. Chem . 280 (38): 32729–35. doi :10.1074/jbc.M504590200 PMID 16020545 . Vasile E, Oka T, Ericsson M, et al. (2006). "IntraGolgi distribution of the Conserved Oligomeric Golgi (COG) complex". Exp. Cell Res . 312 (16): 3132–41. doi :10.1016/j.yexcr.2006.06.005 . PMID 16857184 . 외부 링크
