이중특이성 단백질인산화효소 CLK3는 인간에서 CLK3 유전자에 [5][6]의해 암호화되는 효소이다.CLK3 유전자는 세린/트레오닌형단백질 키나제를 보존되지 않은 N말단 도메인으로 암호화한다.길고 짧은 아이소폼(phclk3 및 pclk3/152)은 대체 스플라이싱에 의해 발생하며 서로 다른 조직에 공존한다.Isoform phclk3/152는 키나아제 [7]도메인이 결여되어 있다.
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