뉴런 특이적 소포 단백질 칼시온 은 CALY [5] [6] 유전자 에 의해 인간에게 암호화되는 단백질 이다.그것의 다른 이름은 칼시온 이다.
기능. 이 유전자에 의해 암호화된 단백질은 II형 단일 막 통과 단백질 이다. 퓨린 작동성 수용체 또는 무스카린성 수용체 자극 후 최대 자극 칼슘 방출에 필요하지만 베타 아드레날린 작동성 수용체에는 필요하지 않다.암호화된 단백질은 도파민 수용체 D1과 상호작용 하며 다른 DA 수용체 아형 및/또는 GPCR과 [6]
상호 작용 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000130643 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000025468 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Heijtz RD, Alexeyenko A, Castellanos FX (July 2007). "Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD" . Behavioral and Brain Functions . 3 (1): 33. doi :10.1186/1744-9081-3-33 . PMC 1949817 PMID 17623072 . ^ a b "CALY calcyon neuron specific vesicular protein [ Homo sapiens (human) ]" .^ Kim JH, Jung HG, Kim A, Shim HS, Hyeon SJ, Lee YS, et al. (March 2021). "Hevin-calcyon interaction promotes synaptic reorganization after brain injury" . Cell Death and Differentiation . doi :10.1038/s41418-021-00772-5 PMID 33753902 . 추가 정보 Milligan G, White JH (October 2001). "Protein-protein interactions at G-protein-coupled receptors". Trends in Pharmacological Sciences . 22 (10): 513–8. doi :10.1016/S0165-6147(00)01801-0 . PMID 11583808 . Ali MK, Bergson C (December 2003). "Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane" . The Journal of Biological Chemistry . 278 (51): 51654–63. doi :10.1074/jbc.M305803200 PMID 14534309 . Luo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J (February 2004). "CALCYON gene variation, schizophrenia, and cocaine dependence". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics . 125B (1): 25–30. doi :10.1002/ajmg.b.20092 . PMID 14755439 . S2CID 24881261 . Laurin N, Misener VL, Crosbie J, Ickowicz A, Pathare T, Roberts W, Malone M, Tannock R, Schachar R, Kennedy JL, Barr CL (December 2005). "Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder" . Molecular Psychiatry . 10 (12): 1117–25. doi :10.1038/sj.mp.4001737 PMID 16172615 . Xiao J, Dai R, Negyessy L, Bergson C (June 2006). "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis" . The Journal of Biological Chemistry . 281 (22): 15182–93. doi :10.1074/jbc.M600265200 PMID 16595675 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Kruusmägi M, Zelenin S, Brismar H, Scott L (October 2007). "Intracellular dynamics of calcyon, a neuron-specific vesicular protein". NeuroReport . 18 (15): 1547–51. doi :10.1097/WNR.0b013e3282f03f51 . PMID 17885599 . S2CID 24544827 .
