호모 사피엔스 종의 단백질 코드 유전자
A-키나아제 앵커단백질 5는 AKAP5 [5] [6] [7] 단백질 이다.
기능. A-키나아제 앵커 단백질(AKAPs)은 단백질 키나아제 A(PKA)의 조절 서브유닛에 결합하고 세포 내의 개별 위치에 홀로엔자임을 제한하는 공통 기능을 가진 구조적으로 다양한 단백질의 그룹이다. 이 유전자는 인트론리스이며 AKAP 패밀리의 일원을 암호화합니다. 암호화된 단백질은 PKA의 RII-베타 조절 서브유닛과 단백질 키나제 C 및 포스파타아제 칼시뉴린 에 결합한다. 그것은 주로 대뇌피질 에서 발현되며 PKA 단백질을 시냅스 후 밀도(PSD)에 고정시키고 시냅스 후 사건의 조절에 관여할 수 있다. 또한 T 림프구 에서도 발현되며, NFAT 의 [7] 인터류킨 2 전사를 억제하는 기능을 할 수 있다.
상호 작용 AKAP5는 다음과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000179841 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000021057 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Carr DW, Stofko-Hahn RE, Fraser ID, Cone RD, Scott JD (Sep 1992). "Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79" . J Biol Chem . 267 (24): 16816–23. doi :10.1016/S0021-9258(18)41856-X PMID 1512224 . ^ Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD (Aug 1992). "Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain" . J Biol Chem . 267 (19): 13376–82. doi :10.1016/S0021-9258(18)42221-1 PMID 1618839 . ^ a b "Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5" .^ Kashishian A, Howard M, Loh C, Gallatin WM, Hoekstra MF, Lai Y (Oct 1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region" . J. Biol. Chem . 273 (42): 27412–9. doi :10.1074/jbc.273.42.27412 PMID 9765270 . ^ Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (Jan 2003). "A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits". Mol. Cell. Neurosci . 22 (1): 87–97. doi :10.1016/s1044-7431(02)00017-9 . PMID 12595241 . 외부 링크 추가 정보 Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res . 52 : 409–29, discussion 429–30. PMID 9238861 . Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol . 42 : 235–57. doi :10.1146/annurev.pharmtox.42.083101.135801 . PMID 11807172 . Hirsch AH, Glantz SB, Li Y, et al. (1992). "Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta" . J. Biol. Chem . 267 (4): 2131–4. doi :10.1016/S0021-9258(18)45852-8 PMID 1733921 . Carr DW, Stofko-Hahn RE, Fraser ID, et al. (1991). "Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif" . J. Biol. Chem . 266 (22): 14188–92. doi :10.1016/S0021-9258(18)98665-5 PMID 1860836 . Coghlan VM, Perrino BA, Howard M, et al. (1995). "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein". Science . 267 (5194): 108–11. doi :10.1126/science.7528941 . PMID 7528941 . Glantz SB, Li Y, Rubin CS (1993). "Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton" . J. Biol. Chem . 268 (17): 12796–804. doi :10.1016/S0021-9258(18)31458-3 PMID 8509414 . Faux MC, Scott JD (1997). "Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin" . J. Biol. Chem . 272 (27): 17038–44. doi :10.1074/jbc.272.27.17038 PMID 9202019 . Kashishian A, Howard M, Loh C, et al. (1998). "AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region" . J. Biol. Chem . 273 (42): 27412–9. doi :10.1074/jbc.273.42.27412 PMID 9765270 . Paolillo M, Feliciello A, Porcellini A, et al. (1999). "The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells" . J. Biol. Chem . 274 (10): 6546–52. doi :10.1074/jbc.274.10.6546 PMID 10037748 . Dodge KL, Carr DW, Sanborn BM (1999). "Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover" . Endocrinology . 140 (11): 5165–70. doi :10.1210/endo.140.11.7133 PMID 10537145 . Fraser ID, Cong M, Kim J, et al. (2000). "Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling" . Curr. Biol . 10 (7): 409–12. doi :10.1016/S0960-9822(00)00419-X PMID 10753752 . Sík A, Gulácsi A, Lai Y, et al. (2000). "Localization of the A kinase anchoring protein AKAP79 in the human hippocampus". Eur. J. Neurosci . 12 (4): 1155–64. doi :10.1046/j.1460-9568.2000.00002.x . PMID 10762347 . Colledge M, Dean RA, Scott GK, et al. (2000). "Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex" . Neuron . 27 (1): 107–19. doi :10.1016/S0896-6273(00)00013-1 PMID 10939335 . Indolfi C, Stabile E, Coppola C, et al. (2001). "Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals" . Circ. Res . 88 (3): 319–24. doi :10.1161/01.res.88.3.319 PMID 11179200 . Dart C, Leyland ML (2001). "Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1" . J. Biol. Chem . 276 (23): 20499–505. doi :10.1074/jbc.M101425200 PMID 11287423 . Xie G, Raufman JP (2001). "Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells". Am. J. Physiol. Gastrointest. Liver Physiol . 281 (4): G1051–8. doi :10.1152/ajpgi.2001.281.4.G1051 . PMID 11557526 .
