호모 사피엔스 종의 단백질 코드 유전자
A-키나아제 앵커단백질 11은 AKAP11 [5] [6] [7] 효소 이다.
기능. A-키나아제 앵커 단백질(AKAPs)은 단백질 키나아제 A(PKA)의 조절 서브유닛에 결합하고 세포 내의 개별 위치에 홀로엔자임을 제한하는 공통 기능을 가진 구조적으로 다양한 단백질의 그룹이다. 이 유전자는 AKAP 패밀리의 일원을 암호화합니다. 암호화된 단백질은 정자 형성을 통해 성숙한 정자에서 높은 수준으로 발현된다. 고환에서 PKA의 RI 및 RII 서브유닛을 결합합니다. 정자 형성과 정자 [7]
상호 작용 AKAP11은 다음과 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000023516 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000022016 - 앙상블, 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Res . 5 (3): 169–76. doi :10.1093/dnares/5.3.169 PMID 9734811 . ^ a b Lester LB, Coghlan VM, Nauert B, Scott JD (June 1996). "Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes" (PDF) . J. Biol. Chem . 271 (16): 9460–5. doi :10.1074/jbc.271.16.9460 PMID 8621616 . ^ a b "Entrez Gene: AKAP11 A kinase (PRKA) anchor protein 11" .^ a b c Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A (October 2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta" . J. Biol. Chem . 277 (40): 36955–61. doi :10.1074/jbc.M206210200 PMID 12147701 . ^ Schillace RV, Scott JD (March 1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220" . Curr. Biol . 9 (6): 321–4. doi :10.1016/S0960-9822(99)80141-9 PMID 10209101 . ^ Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD (April 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring" . Proc. Natl. Acad. Sci. U.S.A . 100 (8): 4445–50. doi :10.1073/pnas.0330734100 PMC 153575 PMID 12672969 . ^ Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (July 2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis" . Dev. Biol . 223 (1): 194–204. doi :10.1006/dbio.2000.9725 PMID 10864471 . ^ Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, et al. (2015). "The BioPlex Network: A Systematic Exploration of the Human Interactome" . Cell . 162 (2): 425–40. doi :10.1016/j.cell.2015.06.043 . PMC 4617211 PMID 26186194 . ^ Mikitova V, Levine TP (2012). "Analysis of the key elements of FFAT-like motifs identifies new proteins that potentially bind VAP on the ER, including two AKAPs and FAPP2" . PLOS ONE . 7 (1): e30455. doi :10.1371/journal.pone.0030455 PMC 3261905 PMID 22276202 . 외부 링크 추가 정보 Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res . 52 : 409–29, discussion 429–30. PMID 9238861 . Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol . 42 : 235–57. doi :10.1146/annurev.pharmtox.42.083101.135801 . PMID 11807172 . Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones" . DNA Res . 9 (3): 99–106. doi :10.1093/dnares/9.3.99 PMID 12168954 . Schillace RV, Scott JD (1999). "Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220" . Curr. Biol . 9 (6): 321–4. doi :10.1016/S0960-9822(99)80141-9 PMID 10209101 . Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (2000). "Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis" . Dev. Biol . 223 (1): 194–204. doi :10.1006/dbio.2000.9725 PMID 10864471 . Schillace RV, Voltz JW, Sim AT, Shenolikar S, Scott JD (2001). "Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation" . J. Biol. Chem . 276 (15): 12128–34. doi :10.1074/jbc.M010398200 PMID 11152471 . Schillace RV, Andrews SF, Liberty GA, Davey MP, Carr DW (2002). "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes" . J. Immunol . 168 (4): 1590–9. doi :10.4049/jimmunol.168.4.1590 PMID 11823486 . Tanji C, Yamamoto H, Yorioka N, Kohno N, Kikuchi K, Kikuchi A (2002). "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta" . J. Biol. Chem . 277 (40): 36955–61. doi :10.1074/jbc.M206210200 PMID 12147701 . 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