비시닌유사단백질1

VSNL1
식별자
에일리어스	VSNL1, HLP3, HPCAL3, HUVISL1, VILIP, VILIP-1, visin like 1
외부 ID	OMIM: 600817 MGI: 1349453 HomoloGene: 2542 GeneCard: VSNL1
유전자 위치(인간)
크르.	2번 염색체(인간)
끝.	17,657,018 bp
유전자 위치(마우스)
크르.	12번 염색체(쥐)
끝.	11,486,614 bp
RNA발현패턴
	상단 표시 위치:
	중측두회; ; 브로드만 23구역; ; 안와전두피질; ; 핀; ; 상전두회; ; 내피 세포; ; 브로드만 10구역; ; 브로드만 영역 46; ; 후두엽; ; 전두극;
	상단 표시 위치:
	일차 운동 피질; ; 상콜리큘러스; ; 폰틴핵; ; 복측 피개부; ; 유두체; ; 내측 배핵; ; 시상하부 외측; ; 내측 유전핵; ; 소뇌충; ; 전전두피질;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	칼슘 이온 결합; 단백질 결합; 금속 이온 결합;
셀룰러 컴포넌트	세포; 막;
생물학적 과정	세포외증의 양성 조절; 포도당 자극에 대한 세포 반응에 관여하는 인슐린 분비의 양성 조절; 인슐린 분비의 음성 조절;
	출처:아미고 / QuickGO
맞춤법
	7447
	26950
	ENSG00000163032
	ENSMUSG000054459
	P62760
	P62761
	NM_003385
	NM_012038; NM_001378929
	NP_003376; NP_001353732; NP_001353733; NP_001353734; NP_001353735
	NP_036168; NP_001365858
	위키데이터
인간 보기/편집	마우스 표시/편집

비시닌유사단백질1은 VSNL1유전자에 ^[5]^[6]^[7]의해 인체 내에서 암호화되는 단백질이다.

이 유전자는 신경 칼슘 센서 ^[8]단백질의 비시닌/리커빈 서브패밀리의 구성원이다.

암호화된 단백질은 칼슘 의존적인 방식으로 세포막과 결합하고 아데닐릴 사이클라아제의 활성을 직간접적으로 조절하여 중추 신경계의 세포 내 신호 경로를 조절하는 소뇌 과립 세포에서 강하게 발현된다.대체적으로 스플라이스된 전사 변형이 관찰되었지만, 그 전체 길이의 특성은 ^[7]결정되지 않았다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000163032 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000054459 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Polymeropoulos MH, Ide S, Soares MB, Lennon GG (Feb 1996). "Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1". Genomics. 29 (1): 273–5. doi:10.1006/geno.1995.1244. PMID 8530085.
^ Kose A, Ito A, Saito N, Tanaka C (Oct 1990). "Electron microscopic localization of gamma- and beta II-subspecies of protein kinase C in rat hippocampus". Brain Res. 518 (1–2): 209–17. doi:10.1016/0006-8993(90)90974-G. PMID 2202488. S2CID 54401066.
^ ^a ^b "Entrez Gene: VSNL1 visinin-like 1".
^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

추가 정보

Kuno T, Kajimoto Y, Hashimoto T, et al. (1992). "cDNA cloning of a neural visinin-like Ca(2+)-binding protein". Biochem. Biophys. Res. Commun. 184 (3): 1219–25. doi:10.1016/S0006-291X(05)80012-9. PMID 1375457.
Lenz SE, Braunewell KH, Weise C, et al. (1996). "The neuronal EF-hand Ca(2+)-binding protein VILIP: interaction with cell membrane and actin-based cytoskeleton". Biochem. Biophys. Res. Commun. 225 (3): 1078–83. doi:10.1006/bbrc.1996.1298. PMID 8780737.
Braunewell KH, Spilker C, Behnisch T, Gundelfinger ED (1997). "The neuronal calcium-sensor protein VILIP modulates cyclic AMP accumulation in stably transfected C6 glioma cells: amino-terminal myristoylation determines functional activity". J. Neurochem. 68 (5): 2129–39. doi:10.1046/j.1471-4159.1997.68052129.x. PMID 9109541. S2CID 29894577.
Kobayashi M, Sakai E, Furuta Y, Takamatsu K (1999). "Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes". DNA Seq. 9 (3): 171–6. doi:10.3109/10425179809072192. PMID 10520747.
Bernstein HG, Baumann B, Danos P, et al. (2000). "Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain". J. Neurocytol. 28 (8): 655–62. doi:10.1023/A:1007056731551. PMID 10851344. S2CID 7944931.
Braunewell KH, Brackmann M, Schaupp M, et al. (2001). "Intracellular neuronal calcium sensor (NCS) protein VILIP-1 modulates cGMP signalling pathways in transfected neural cells and cerebellar granule neurones". J. Neurochem. 78 (6): 1277–86. doi:10.1046/j.1471-4159.2001.00506.x. PMID 11579136. S2CID 41831236.
Schnurra I, Bernstein HG, Riederer P, Braunewell KH (2002). "The neuronal calcium sensor protein VILIP-1 is associated with amyloid plaques and extracellular tangles in Alzheimer's disease and promotes cell death and tau phosphorylation in vitro: a link between calcium sensors and Alzheimer's disease?". Neurobiol. Dis. 8 (5): 900–9. doi:10.1006/nbdi.2001.0432. PMID 11592857. S2CID 45639709.
Bernstein HG, Braunewell KH, Spilker C, et al. (2002). "Hippocampal expression of the calcium sensor protein visinin-like protein-1 in schizophrenia". NeuroReport. 13 (4): 393–6. doi:10.1097/00001756-200203250-00006. PMID 11930147. S2CID 22907782.
Spilker C, Dresbach T, Braunewell KH (2002). "Reversible translocation and activity-dependent localization of the calcium-myristoyl switch protein VILIP-1 to different membrane compartments in living hippocampal neurons". J. Neurosci. 22 (17): 7331–9. doi:10.1523/JNEUROSCI.22-17-07331.2002. PMC 6757958. PMID 12196554.
Lin L, Braunewell KH, Gundelfinger ED, Anand R (2002). "Functional analysis of calcium-binding EF-hand motifs of visinin-like protein-1". Biochem. Biophys. Res. Commun. 296 (4): 827–32. doi:10.1016/S0006-291X(02)00943-9. PMID 12200122.
Lin L, Jeanclos EM, Treuil M, et al. (2003). "The calcium sensor protein visinin-like protein-1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor". J. Biol. Chem. 277 (44): 41872–8. doi:10.1074/jbc.M206857200. PMID 12202488.
Spilker C, Gundelfinger ED, Braunewell KH (2002). "Evidence for different functional properties of the neuronal calcium sensor proteins VILIP-1 and VILIP-3: from subcellular localization to cellular function". Biochim. Biophys. Acta. 1600 (1–2): 118–27. doi:10.1016/s1570-9639(02)00452-1. PMID 12445467.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Braunewell KH, Brackmann M, Manahan-Vaughan D (2003). "Group I mGlu receptors regulate the expression of the neuronal calcium sensor protein VILIP-1 in vitro and in vivo: implications for mGlu receptor-dependent hippocampal plasticity?". Neuropharmacology. 44 (6): 707–15. doi:10.1016/S0028-3908(03)00051-0. PMID 12681369. S2CID 20047130.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gonzalez Guerrico AM, Jaffer ZM, Page RE, et al. (2005). "Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells". Oncogene. 24 (14): 2307–16. doi:10.1038/sj.onc.1208476. PMID 15735716.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Jheng FF, Wang L, Lee L, Chang LS (2007). "Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteins". Protein J. 25 (4): 250–6. doi:10.1007/s10930-006-9008-5. PMID 16703469. S2CID 29486237.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

인간 염색체 2번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000163032 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000054459 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530085-5] Polymeropoulos MH, Ide S, Soares MB, Lennon GG (Feb 1996). "Sequence characterization and genetic mapping of the human VSNL1 gene, a homologue of the rat visinin-like peptide RNVP1". Genomics. 29 (1): 273–5. doi:10.1006/geno.1995.1244. PMID 8530085.

[pmid2202488-6] Kose A, Ito A, Saito N, Tanaka C (Oct 1990). "Electron microscopic localization of gamma- and beta II-subspecies of protein kinase C in rat hippocampus". Brain Res. 518 (1–2): 209–17. doi:10.1016/0006-8993(90)90974-G. PMID 2202488. S2CID 54401066.

[entrez-7] "Entrez Gene: VSNL1 visinin-like 1".

[pmid17311005-8] Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

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비시닌유사단백질1

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