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VARS1
식별자
에일리어스	VAR1, G7A, VAR2, Valyl-tRNA 합성효소, NDMSCA, Valyl-tRNA 합성효소 1, VARS
외부 ID	OMIM: 192150MGI: 90675 HomoloGene: 4587 GenCard: VAR1
유전자 위치(인간)
크르.	6번 염색체(인간)
끝.	31,795,752 bp
유전자 위치(마우스)
크르.	17번 염색체(쥐)
끝.	35,235,298 bp
RNA발현패턴
	상단 표시 위치:
	랑게르한스 섬; ; 뇌하수체; ; 신경절 융기; ; 부록; ; 뇌하수체 전엽; ; 자궁내막간질세포; ; 위근; ; 근육 조직; ; 골격근 조직; ; 췌장체;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	아미노아실tRNA리가수분해효소활성; 뉴클레오티드 결합; 리가아제활성; GO:0001948, GO:0016582 단백질 결합; ATP 결합; 아미노아실tRNA편집활성; 발린tRNA리가수분해효소활성;
셀룰러 컴포넌트	세포질; 세포;
생물학적 과정	단백질 번역용 tRNA 아미노아실화; 단백질생합성; 발릴tRNA아미노아실화; 번역 충실도에 관여하는 아미노아실-tRNA 대사;
	출처:아미고 / QuickGO
맞춤법
	7407
	22321
ENSG00000226589; ENSG000096171; ENSG000002345; ENSG00000227686; ENSG00000204394;
	ENSG00000224264; ENSG00000231116
	ENSMUSG00000007029
	P26640
	Q9Z1Q9
	NM_006295
	NM_011690
	NP_006286; NP_006286.1
	NP_035820
	위키데이터
인간 보기/편집	마우스 표시/편집

Valyl-tRNA 합성효소는 사람에게서 VARs ^[5]^[6]유전자에 의해 암호화되는 효소이다.

기능.

아미노아실-tRNA 합성효소는 동족 아미노산에 의해 tRNA의 아미노화를 촉매한다.아미노산을 tRNA에 포함된 뉴클레오티드 세쌍둥이와 연결하는 중심적인 역할 때문에, 아미노아실-tRNA 합성효소는 진화에 나타난 최초의 단백질 중 하나로 여겨진다.이 유전자에 의해 코드된 단백질은 클래스 I 아미노아실-tRNA 합성효소 계열에 속하며 주요 조직적합성 ^[6]복합체의 클래스 III 영역에 위치한다.

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발린-tRNA 리가아제

레퍼런스

^ ^a ^b ^c ENSG000096171, ENSG00000231945, ENSG00000227686, ENSG00000204394, ENSG00000224264, ENSG00000231116 GRCh38: Ensembel 릴리즈 89: ENSG00000226589, ENSG0096,000016
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000007029 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bonnefond L, Fender A, Rudinger-Thirion J, Giegé R, Florentz C, Sissler M (March 2005). "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS". Biochemistry. 44 (12): 4805–16. doi:10.1021/bi047527z. PMID 15779907.
^ ^a ^b "Entrez Gene: VARS valyl-tRNA synthetase".

추가 정보

Hsieh SL, Campbell RD (September 1991). "Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase". The Biochemical Journal. 278 (3): 809–16. doi:10.1042/bj2780809. PMC 1151418. PMID 1898367.
Sargent CA, Dunham I, Campbell RD (August 1989). "Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region". The EMBO Journal. 8 (8): 2305–12. doi:10.1002/j.1460-2075.1989.tb08357.x. PMC 401163. PMID 2477242.
Bec G, Kerjan P, Zha XD, Waller JP (December 1989). "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1". The Journal of Biological Chemistry. 264 (35): 21131–7. PMID 2556394.
Wolfson AD, Orlovsky AF, Gladilin KL (October 1988). "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor". FEBS Letters. 238 (2): 262–4. doi:10.1016/0014-5793(88)80492-7. PMID 3169261. S2CID 45934458.
Bec G, Kerjan P, Waller JP (January 1994). "Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation". The Journal of Biological Chemistry. 269 (3): 2086–92. PMID 8294461.
Vilalta A, Donovan D, Wood L, Vogeli G, Yang DC (January 1993). "Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase". Gene. 123 (2): 181–6. doi:10.1016/0378-1119(93)90122-J. PMID 8428657.
Motorin Y (May 1996). "Two human valyl-tRNA synthetase-encoding cDNA sequences deposited in GenBank display extensive differences". Gene. 170 (2): 289–91. doi:10.1016/0378-1119(96)84699-3. PMID 8666263.
Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L (December 2003). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Jiang S, Wolfe CL, Warrington JA, Norcum MT (November 2005). "Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit". FEBS Letters. 579 (27): 6049–54. doi:10.1016/j.febslet.2005.09.062. PMID 16229838. S2CID 83645345.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

이 단백질 관련 기사는 스텁입니다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] ENSG000096171, ENSG00000231945, ENSG00000227686, ENSG00000204394, ENSG00000224264, ENSG00000231116 GRCh38: Ensembel 릴리즈 89: ENSG00000226589, ENSG0096,000016

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000007029 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15779907-5] Bonnefond L, Fender A, Rudinger-Thirion J, Giegé R, Florentz C, Sissler M (March 2005). "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS". Biochemistry. 44 (12): 4805–16. doi:10.1021/bi047527z. PMID 15779907.

[entrez-6] "Entrez Gene: VARS valyl-tRNA synthetase".

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