트롬보스폰딘-2

THBS2
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1YO8, 2RHP
식별자
에일리어스	THBS2, TSP2, 트롬보스폰딘2
외부 ID	OMIM: 188061 MGI: 98738 HomoloGene: 2438 GeneCard: THBS2
유전자 위치(인간)
크르.	6번 염색체(인간)
끝.	169,254,044 bp
유전자 위치(마우스)
크르.	17번 염색체(쥐)
끝.	14,914,497 bp
RNA발현패턴
	상단 표시 위치:
	심막; ; 우관상 동맥; ; 자궁내막간질세포; ; 복정맥; ; 경골; ; 모낭; ; 흉부 대동맥; ; 상행 대동맥; ; 활액관절; ; 대정맥;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	칼슘 이온 결합; GO:0001948 단백질 결합; 헤파린 결합; 세포외기질구조성분;
셀룰러 컴포넌트	GO:0005578 세포외 매트릭스; 혈소판 알파 과립; 기저막; 세포외 영역; 세포외 공간; 콜라겐 함유 세포외 매트릭스;
생물학적 과정	시냅스 어셈블리의 양성 조절; 혈관신생의 음성 조절; 세포 접착; 세포외 매트릭스 구성;
	출처:아미고 / QuickGO
맞춤법
	7058
	21826
	ENSG00000186340
	ENSMUSG000023885
	P35442
	Q03350
	NM_003247
	NM_011581
	NP_003238; NP_001368868; NP_001368869; NP_001368870; NP_001368871
	NP_035711
	위키데이터
인간 보기/편집	마우스 표시/편집

트롬보스폰딘-2는 인간의 THBS2 ^[5]^[6]유전자에 의해 암호화되는 단백질이다.

이 유전자에 의해 암호화된 단백질은 트롬보스폰딘 계열에 속합니다.이황화물 결합 호모트리머 당단백질로서 세포-세포 및 세포-매트릭스 상호작용을 매개한다.암에서 단백질의 역할은 논란의 여지가 있으며, 대조적인 연구는 암 발생에 긍정적인 역할과 부정적인 역할을 보여준다.마우스 상대물의 연구는 이 단백질이 간엽세포의 세포 표면 특성을 조절하고 세포 접착 및 ^[6]이동에 관여할 수 있음을 시사한다.

상호 작용

THBS2는 MMP2와 ^[7]상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000186340 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000023885 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008). "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation". American Journal of Human Genetics. 82 (5): 1122–9. doi:10.1016/j.ajhg.2008.03.013. PMC 2427305. PMID 18455130.
^ ^a ^b "Entrez Gene: THBS2 thrombospondin 2".
^ Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal of Biological Chemistry. 275 (41): 32167–73. doi:10.1074/jbc.M003834200. PMID 10900205.

추가 정보

Bornstein P, Kyriakides TR, Yang Z, Armstrong LC, Birk DE (Dec 2000). "Thrombospondin 2 modulates collagen fibrillogenesis and angiogenesis". The Journal of Investigative Dermatology. Symposium Proceedings. 5 (1): 61–6. doi:10.1046/j.1087-0024.2000.00005.x. PMID 11147677.
O'Rourke KM, Laherty CD, Dixit VM (Dec 1992). "Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers". The Journal of Biological Chemistry. 267 (35): 24921–4. PMID 1459996.
LaBell TL, Milewicz DJ, Disteche CM, Byers PH (Mar 1992). "Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans". Genomics. 12 (3): 421–9. doi:10.1016/0888-7543(92)90430-Z. PMID 1559694.
LaBell TL, Byers PH (Jul 1993). "Sequence and characterization of the complete human thrombospondin 2 cDNA: potential regulatory role for the 3' untranslated region". Genomics. 17 (1): 225–9. doi:10.1006/geno.1993.1308. PMID 8406456.
Adolph KW, Liska DJ, Bornstein P (Jul 1997). "Analysis of the promoter and transcription start sites of the human thrombospondin 2 gene (THBS2)". Gene. 193 (1): 5–11. doi:10.1016/S0378-1119(97)00070-X. PMID 9249061.
Kyriakides TR, Zhu YH, Smith LT, Bain SD, Yang Z, Lin MT, Danielson KG, Iozzo RV, LaMarca M, McKinney CE, Ginns EI, Bornstein P (Jan 1998). "Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis". The Journal of Cell Biology. 140 (2): 419–30. doi:10.1083/jcb.140.2.419. PMC 2132586. PMID 9442117.
Adolph KW (May 1999). "Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues". Biochemical and Biophysical Research Communications. 258 (3): 792–6. doi:10.1006/bbrc.1999.0710. PMID 10329465.
Carron JA, Bowler WB, Wagstaff SC, Gallagher JA (Sep 1999). "Expression of members of the thrombospondin family by human skeletal tissues and cultured cells". Biochemical and Biophysical Research Communications. 263 (2): 389–91. doi:10.1006/bbrc.1999.1380. PMID 10491303.
Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal of Biological Chemistry. 275 (41): 32167–73. doi:10.1074/jbc.M003834200. PMID 10900205.
Hawighorst T, Velasco P, Streit M, Hong YK, Kyriakides TR, Brown LF, Bornstein P, Detmar M (Jun 2001). "Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism". The EMBO Journal. 20 (11): 2631–40. doi:10.1093/emboj/20.11.2631. PMC 125494. PMID 11387198.
Misenheimer TM, Hahr AJ, Harms AC, Annis DS, Mosher DF (Dec 2001). "Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2". The Journal of Biological Chemistry. 276 (49): 45882–7. doi:10.1074/jbc.M104218200. PMID 11590138.
Armstrong DJ, Hiscott P, Batterbury M, Kaye S (Jun 2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype". The International Journal of Biochemistry & Cell Biology. 34 (6): 588–93. doi:10.1016/S1357-2725(01)00157-1. PMID 11943589.
Li Z, Calzada MJ, Sipes JM, Cashel JA, Krutzsch HC, Annis DS, Mosher DF, Roberts DD (Apr 2002). "Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior". The Journal of Cell Biology. 157 (3): 509–19. doi:10.1083/jcb.200109098. PMC 2173289. PMID 11980922.
Armstrong LC, Björkblom B, Hankenson KD, Siadak AW, Stiles CE, Bornstein P (Jun 2002). "Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism". Molecular Biology of the Cell. 13 (6): 1893–905. doi:10.1091/mbc.E01-09-0066. PMC 117612. PMID 12058057.
Hatakeyama H, Nishizawa M, Nakagawa A, Nakano S, Kigoshi T, Miyamori I, Uchida K (Jul 2002). "Thrombospondin expression in aldosterone-producing adenomas". Hypertension Research. 25 (4): 523–7. doi:10.1291/hypres.25.523. PMID 12358136.
Boekholdt SM, Trip MD, Peters RJ, Engelen M, Boer JM, Feskens EJ, Zwinderman AH, Kastelein JJ, Reitsma PH (Dec 2002). "Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction". Arteriosclerosis, Thrombosis, and Vascular Biology. 22 (12): e24–7. doi:10.1161/01.ATV.0000046235.22451.66. PMID 12482844.
Kyriakides TR, Rojnuckarin P, Reidy MA, Hankenson KD, Papayannopoulou T, Kaushansky K, Bornstein P (May 2003). "Megakaryocytes require thrombospondin-2 for normal platelet formation and function". Blood. 101 (10): 3915–23. doi:10.1182/blood.V101.10.3915. PMID 12732502.
Kishi M, Nakamura M, Nishimine M, Ishida E, Shimada K, Kirita T, Konishi N (Jun 2003). "Loss of heterozygosity on chromosome 6q correlates with decreased thrombospondin-2 expression in human salivary gland carcinomas". Cancer Science. 94 (6): 530–5. doi:10.1111/j.1349-7006.2003.tb01478.x. PMID 12824879. S2CID 19472764.

인간 염색체 6번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000186340 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000023885 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18455130-5] Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008). "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation". American Journal of Human Genetics. 82 (5): 1122–9. doi:10.1016/j.ajhg.2008.03.013. PMC 2427305. PMID 18455130.

[entrez-6] "Entrez Gene: THBS2 thrombospondin 2".

[pmid10900205-7] Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal of Biological Chemistry. 275 (41): 32167–73. doi:10.1074/jbc.M003834200. PMID 10900205.

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트롬보스폰딘-2

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