SPDEF

SPDEF
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2DKX
식별자
에일리어스	SPDEF, PDEF, bA375E1.3, ETS 전사 계수를 포함한 SAM 포인트 도메인
외부 ID	OMIM: 608144 MGI: 1353422 HomoloGene: 8231 GeneCard: SPDEF
유전자 위치(인간)
크르.	6번 염색체(인간)
끝.	34,556,333 bp
유전자 위치(마우스)
크르.	17번 염색체(쥐)
끝.	27,947,929 bp
RNA발현패턴
	상단 표시 위치:
	이하선; ; 전립선; ; 기관; ; 유즙관; ; 소침샘; ; 안검결막; ; 기관지; ; 우측 자궁관; ; 기관지 상피 세포; ; 위체;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	GO:0001131, GO:000115, GO:0001130, GO:0001204 DNA결합전사인자액티비티; DNA결합; GO:0001078, GO:0001214, GO:0001206 DNA결합전사억제제활성, RNA중합효소II 특이적; 배열특이적 DNA결합; GO:0001200, GO:0001133, GO:0001201 DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	핵;
생물학적 과정	다세포 생물 발달; 세포 분화; 전사조절, DNA템플릿화; RNA중합효소II에 의한 전사 음성 조절; 세포운명약속부정조절; 폐고블렛세포분화; 장상피세포발달; 전사, DNA 템플릿; 세포운명약정긍정조절; RNA중합효소II에 의한 전사의 양성 조절; 아포토시스 과정의 양성 조절; RNA중합효소II에 의한 전사조절;
	출처:아미고 / QuickGO
맞춤법
	25803
	30051
	ENSG00000124664
	ENSMUSG000024215
	O95238
	Q9WTP3
	NM_001252294; NM_012391
	NM_013891; NM_001357728
	NP_001239223; NP_036523
	NP_038919; NP_001344657
	위키데이터
인간 보기/편집	마우스 표시/편집

SAM 지적 도메인을 포함한 Ets 전사인자는 SPDEF ^[5]^[6]^[7]유전자에 의해 인간에게 암호화되는 단백질이다.

PDEF는 전립선 상피 세포에서 발현되는 ETS 전사 인자이다.PSA(MIM 176820) 발현에 대한 안드로겐 비의존적 트랜스활성화제 역할을 한다.[OMIM ^[7]제공]

상호 작용

SPDEF는 NKX3-1과 ^[8]상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000124664 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000024215 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Oettgen P, Finger E, Sun Z, Akbarali Y, Thamrongsak U, Boltax J, et al. (January 2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression". The Journal of Biological Chemistry. 275 (2): 1216–1225. doi:10.1074/jbc.275.2.1216. PMID 10625666.
^ Johannessen JV, Finseth I (January 1983). "Electron micrographs in five minutes". Ultrastructural Pathology. 4 (1): 97–100. doi:10.3109/01913128309140576. PMID 6857767.
^ ^a ^b "Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor".
^ Chen H, Nandi AK, Li X, Bieberich CJ (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Research. 62 (2): 338–340. PMID 11809674.

추가 정보

Lance V (1976). "Studies on the annual reproductive cycle of the female cobra, Naja naja. Seasonal variation in plasma inorganic ions". Comparative Biochemistry and Physiology. A, Comparative Physiology. 53 (3): 285–289. doi:10.1016/S0300-9629(76)80037-0. PMID 2437.
Yamada N, Tamai Y, Miyamoto H, Nozaki M (January 2000). "Cloning and expression of the mouse Pse gene encoding a novel Ets family member". Gene. 241 (2): 267–274. doi:10.1016/S0378-1119(99)00484-9. PMID 10675039.
Chen H, Nandi AK, Li X, Bieberich CJ (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Research. 62 (2): 338–340. PMID 11809674.
Thompson HG, Harris JW, Wold BJ, Lin F, Brody JP (April 2003). "p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells". Oncogene. 22 (15): 2322–2333. doi:10.1038/sj.onc.1206325. PMID 12700667.
Feldman RJ, Sementchenko VI, Gayed M, Fraig MM, Watson DK (August 2003). "Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression". Cancer Research. 63 (15): 4626–4631. PMID 12907642.
Ghadersohi A, Odunsi K, Lele S, Collins Y, Greco WR, Winston J, et al. (February 2004). "Prostate derived Ets transcription factor shows better tumor-association than other cancer-associated molecules". Oncology Reports. 11 (2): 453–458. doi:10.3892/or.11.2.453. PMID 14719083.
Chen H, Bieberich CJ (January 2005). "Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF". Journal of Cellular Biochemistry. 94 (1): 168–177. doi:10.1002/jcb.20297. PMID 15523673. S2CID 46494570.
Wang Y, Feng L, Said M, Balderman S, Fayazi Z, Liu Y, et al. (May 2005). "Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site". Biochemistry. 44 (19): 7095–7106. doi:10.1021/bi047352t. PMID 15882048.
Fowler M, Borazanci E, McGhee L, Pylant SW, Williams BJ, Glass J, et al. (January 2006). "RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region". Journal of Cellular Biochemistry. 97 (1): 1–17. doi:10.1002/jcb.20664. PMID 16237704. S2CID 20541109.
Gunawardane RN, Sgroi DC, Wrobel CN, Koh E, Daley GQ, Brugge JS (December 2005). "Novel role for PDEF in epithelial cell migration and invasion". Cancer Research. 65 (24): 11572–11580. doi:10.1158/0008-5472.CAN-05-1196. PMC 2919290. PMID 16357167.
Rodabaugh KJ, Mhawech-Fauceglia P, Groth J, Lele S, Sood AK (January 2007). "Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumors". International Journal of Gynecological Pathology. 26 (1): 10–15. doi:10.1097/01.pgp.0000225386.41244.bd. PMID 17197890. S2CID 25880565.
Park KS, Korfhagen TR, Bruno MD, Kitzmiller JA, Wan H, Wert SE, et al. (April 2007). "SPDEF regulates goblet cell hyperplasia in the airway epithelium". The Journal of Clinical Investigation. 117 (4): 978–988. doi:10.1172/JCI29176. PMC 1810569. PMID 17347682.

인간 염색체 6번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000124664 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000024215 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10625666-5] Oettgen P, Finger E, Sun Z, Akbarali Y, Thamrongsak U, Boltax J, et al. (January 2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression". The Journal of Biological Chemistry. 275 (2): 1216–1225. doi:10.1074/jbc.275.2.1216. PMID 10625666.

[pmid6857767-6] Johannessen JV, Finseth I (January 1983). "Electron micrographs in five minutes". Ultrastructural Pathology. 4 (1): 97–100. doi:10.3109/01913128309140576. PMID 6857767.

[entrez-7] "Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor".

[pmid11809674-8] Chen H, Nandi AK, Li X, Bieberich CJ (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Research. 62 (2): 338–340. PMID 11809674.

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SPDEF

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상호 작용

레퍼런스

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