Synphilin-1 은 인간에게 SNCAIP 유전자 에 의해 암호화된 단백질 이다.[5] [6] SNCAIP 는 "시뉴클레인, 알파 상호작용 단백질"을 의미하며 SNCAP_로 나타낼 수 있다.HUMAN, Synphilin 1, Synuclein, 알파 상호작용 단백질(Synphilin), SYPH1.
함수 이 유전자는 앙키린 과 같은 반복, 코일 영역, ATP/GTP 바인딩 모티브 등 여러 단백질-단백질 상호작용 영역을 포함하는 단백질을 암호화한다. 암호화된 단백질은 뉴런 조직 에서 알파 시뉴클레인 과 상호작용하며 세포질포착 과 신경분열 생성에 역할을 할 수 있다. 이 유전자의 돌연변이는 파킨슨병 과 관련이 있다. 대안으로 이 유전자의 다른 ISO 형식을 인코딩하는 분할된 대본 변형이 설명되었지만, 그들의 전체 길이 속성은 아직 결정되지 않았다.[6]
SNCAIP 유전자는 Synphilin-1이라고 불리는 단백질과 Synphilin-1A라고 불리는 이 단백질의 약간 다른 버전을 만드는 방법을 제공한다. 이 단백질들은 뇌에서 생성된다. 그것들은 보통 신경 세포의 끝에서 발견되는 사전 시냅스 단자라 불리는 특수한 구조물에 위치한다. 신경세포에서, synphilin-1과 synphilin-1A는 알파-synuclein이라고 불리는 또 다른 단백질과 상호작용한다. 그러나 synphilin-1과 synphilin-1A의 기능은 알려져 있지 않다.
상호작용 SNCAIP는 다음과 상호 작용하는 것으로 나타났다.
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