호모 사피엔스 종의 단백질 코드 유전자
SH2 도메인 함유 단백질 1B 는 SH2D1B [5] [6] [7] 유전자 에 의해 인체 내에서 암호화되는 단백질 이다.
EAT2는 유리 SRC(MIM 190090) 호몰로지-2(SH2) 도메인을 통해 포스포티로신을 결합시킴으로써 항원 제시 세포 표면에 발현되는 수용체를 통한 신호 전달을 조절한다(Morra et al., 2001). [OMIM [7]
상호 작용 SH2D1B는 SLAMF1 과 [6] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000198574 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000102418 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Thompson AD, Braun BS, Arvand A, Stewart SD, May WA, Chen E, Korenberg J, Denny C (Feb 1997). "EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene". Oncogene . 13 (12): 2649–58. PMID 9000139 . ^ a b Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (Nov 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells" . EMBO J . 20 (21): 5840–52. doi :10.1093/emboj/20.21.5840 . PMC 125701 PMID 11689425 . ^ a b "Entrez Gene: SH2D1B SH2 domain containing 1B" .
추가 정보 Morra M, Howie D, Grande MS, et al. (2001). "X-linked lymphoproliferative disease: a progressive immunodeficiency". Annu. Rev. Immunol . 19 : 657–82. doi :10.1146/annurev.immunol.19.1.657 . PMID 11244050 . Veillette A, Latour S (2004). "The SLAM family of immune-cell receptors". Curr. Opin. Immunol . 15 (3): 277–85. doi :10.1016/S0952-7915(03)00041-4 . PMID 12787752 . Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2" . Eur. J. Immunol . 32 (6): 1640–9. doi :10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S PMID 12115647 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Eissmann P, Watzl C (2006). "Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells" . J. Immunol . 177 (5): 3170–7. doi :10.4049/jimmunol.177.5.3170 PMID 16920955 .
