호모 사피엔스에서 발견되는 포유류의 단백질
단백질 수송 단백질 Sec61 서브유닛 베타는 SEC61B [5] [6] [7] 단백질 이다.
Sec61 복합체는 소포체 (ER) 막의 단백질 전위 장치의 중심 성분이다. Sec61 복합체는 단백질이 ER 막에 걸쳐 위치하여 통합되는 막 통과 채널을 형성한다. 이 복합체는 알파, 베타, 감마라는 세 가지 막 단백질로 구성되어 있다. 이 유전자는 베타 서브유닛 단백질을 암호화한다. Sec61 서브유닛은 ER 후 구획에서도 관찰되며, 이는 이러한 단백질이 ER을 빠져나와 재활용될 수 있음을 시사한다. 이 [7]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000106803 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000053317 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA (Mar 1994). "Evolutionary conservation of components of the protein translocation complex". Nature . 367 (6464): 654–7. Bibcode :1994Natur.367..654H . doi :10.1038/367654a0 . PMID 8107851 . S2CID 4323463 . ^ Greenfield JJ, High S (Aug 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J Cell Sci . 112 (10): 1477–86. doi :10.1242/jcs.112.10.1477 . PMID 10212142 . ^ a b "Entrez Gene: SEC61B Sec61 beta subunit" . 추가 정보 Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Wiertz EJ, Tortorella D, Bogyo M, et al. (1997). "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature . 384 (6608): 432–8. doi :10.1038/384432a0 . PMID 8945469 . S2CID 6276718 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex" . Biochem. J . 331 (Pt 1): 161–7. doi :10.1042/bj3310161 . PMC 1219334 PMID 9512475 . Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex" . J. Biol. Chem . 273 (19): 11887–94. doi :10.1074/jbc.273.19.11887 PMID 9565615 . Kalies KU, Rapoport TA, Hartmann E (1998). "The β Subunit of the Sec61 Complex Facilitates Cotranslational Protein Transport and Interacts with the Signal Peptidase during Translocation" . J. Cell Biol . 141 (4): 887–94. doi :10.1083/jcb.141.4.887 . PMC 2132780 PMID 9585408 . Bebök Z, Mazzochi C, King SA, et al. (1998). "The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary" . J. Biol. Chem . 273 (45): 29873–8. doi :10.1074/jbc.273.45.29873 PMID 9792704 . Ingley E, Williams JH, Walker CE, et al. (1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit" . FEBS Lett . 459 (1): 69–74. doi :10.1016/S0014-5793(99)01188-6 PMID 10508919 . S2CID 30948975 . Yamaguchi A, Hori O, Stern DM, et al. (2000). "Stress-Associated Endoplasmic Reticulum Protein 1 (Serp1)/Ribosome-Associated Membrane Protein 4 (Ramp4) Stabilizes Membrane Proteins during Stress and Facilitates Subsequent Glycosylation" . J. Cell Biol . 147 (6): 1195–204. doi :10.1083/jcb.147.6.1195 . PMC 2168098 PMID 10601334 . Meyer HA, Grau H, Kraft R, et al. (2000). "Mammalian Sec61 is associated with Sec62 and Sec63" . J. Biol. Chem . 275 (19): 14550–7. doi :10.1074/jbc.275.19.14550 PMID 10799540 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9" . Nature . 429 (6990): 369–74. Bibcode :2004Natur.429..369H . doi :10.1038/nature02465 . PMC 2734081 PMID 15164053 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Besemer J, Harant H, Wang S, et al. (2005). "Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1". Nature . 436 (7048): 290–3. Bibcode :2005Natur.436..290B . doi :10.1038/nature03670 . PMID 16015337 . S2CID 4431610 . Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res . 4 (4): 1339–46. doi :10.1021/pr050048h . PMID 16083285 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Liao HJ, Carpenter G (2007). "Role of the Sec61 Translocon in EGF Receptor Trafficking to the Nucleus and Gene Expression" . Mol. Biol. Cell . 18 (3): 1064–72. doi :10.1091/mbc.E06-09-0802 . PMC 1805100 PMID 17215517 . 
