RING 핑거 및 CHY 아연 핑거 도메인 함유 단백질 1 은 RCHY1 [4] 단백질 이다.
기능. 이 유전자에 의해 코드된 단백질은 유비퀴틴-단백질 연결효소 활성을 가지고 있다. 이 단백질은 p53과 결합하고 p53의 유비퀴틴 매개 단백질 분해를 촉진한다. 이 유전자는 p53 기능의 상실이 악성 종양 발생에 직접적으로 기여하기 때문에 암을 유발한다. 이 유전자의 전사는 p53에 의해 조절된다. 대체 스플라이싱으로 인해 여러 개의 트랜스크립트 배리언트가 서로 다른 [4]
상호 작용 RCHY1은 P53 [5] [6] Androgen [7] 것 으로 나타났다.
레퍼런스 ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000029397 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: RCHY1 ring finger and CHY zinc finger domain containing 1" .^ Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S (Mar 2003). "Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation" . Cell . 112 (6): 779–91. doi :10.1016/S0092-8674(03)00193-4 PMID 12654245 . S2CID 9316769 . ^ Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, Lukin J, Sunnerhagen M, Srisailam S, Karra M, Benchimol S, Arrowsmith CH (Dec 2008). "Molecular basis of Pirh2-mediated p53 ubiquitylation" . Nature Structural & Molecular Biology . 15 (12): 1334–42. doi :10.1038/nsmb.1521 . PMC 4075976 PMID 19043414 . ^ Beitel LK, Elhaji YA, Lumbroso R, Wing SS, Panet-Raymond V, Gottlieb B, Pinsky L, Trifiro MA (Aug 2002). "Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity" . Journal of Molecular Endocrinology . 29 (1): 41–60. doi :10.1677/jme.0.0290041 PMID 12200228 . 추가 정보 Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Research . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Beitel LK, Elhaji YA, Lumbroso R, Wing SS, Panet-Raymond V, Gottlieb B, Pinsky L, Trifiro MA (Aug 2002). "Cloning and characterization of an androgen receptor N-terminal-interacting protein with ubiquitin-protein ligase activity" . Journal of Molecular Endocrinology . 29 (1): 41–60. doi :10.1677/jme.0.0290041 PMID 12200228 . Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S (Mar 2003). "Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation" . Cell . 112 (6): 779–91. doi :10.1016/S0092-8674(03)00193-4 PMID 12654245 . S2CID 9316769 . Logan IR, Sapountzi V, Gaughan L, Neal DE, Robson CN (Mar 2004). "Control of human PIRH2 protein stability: involvement of TIP60 and the proteosome" . The Journal of Biological Chemistry . 279 (12): 11696–704. doi :10.1074/jbc.M312712200 PMID 14701804 . Corcoran CA, Huang Y, Sheikh MS (Aug 2004). "The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest" . Cancer Biology & Therapy . 3 (8): 721–5. doi :10.4161/cbt.3.8.1068 PMID 15280670 . Duan W, Gao L, Druhan LJ, Zhu WG, Morrison C, Otterson GA, Villalona-Calero MA (Nov 2004). "Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer" . Journal of the National Cancer Institute . 96 (22): 1718–21. doi :10.1093/jnci/djh292 PMID 15547185 . Zhang L, Li J, Wang C, Ma Y, Huo K (Apr 2005). "A new human gene hNTKL-BP1 interacts with hPirh2". Biochemical and Biophysical Research Communications . 330 (1): 293–7. doi :10.1016/j.bbrc.2005.02.156 . PMID 15781263 . Logan IR, Gaughan L, McCracken SR, Sapountzi V, Leung HY, Robson CN (Sep 2006). "Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer" . Molecular and Cellular Biology . 26 (17): 6502–10. doi :10.1128/MCB.00147-06 . PMC 1592843 PMID 16914734 . Duan W, Gao L, Wu X, Zhang Y, Otterson GA, Villalona-Calero MA (Oct 2006). "Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells". Experimental Cell Research . 312 (17): 3370–8. doi :10.1016/j.yexcr.2006.07.005 . PMID 16934800 . Duan S, Yao Z, Hou D, Wu Z, Zhu WG, Wu M (Jul 2007). "Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53" . The EMBO Journal . 26 (13): 3062–74. doi :10.1038/sj.emboj.7601749 . PMC 1914097 PMID 17568776 . Hattori T, Isobe T, Abe K, Kikuchi H, Kitagawa K, Oda T, Uchida C, Kitagawa M (Nov 2007). "Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1" . Cancer Research . 67 (22): 10789–95. doi :10.1158/0008-5472.CAN-07-2033 PMID 18006823 . 
