RAB11FIP1

RAB11FIP1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	4D0G
식별자
에일리어스	RAB11FIP1, NOEL1A, RCP, Rab11-FIP1, RAB11 패밀리 상호작용 단백질 1
외부 ID	OMIM : 608737 MGI : 1923017 HomoloGene : 11853 GenCard : RAB11FIP1
유전자 위치(인간)
크르.	8번 염색체(인간)
끝.	37,89,497 bp
유전자 위치(마우스)
크르.	8번 염색체(쥐)
끝.	27,664,674 bp
RNA발현패턴
	상단 표시 위치:
	폐하엽; ; 양수; ; 기관지 상피 세포; ; 구강; ; 랑게르한스 섬; ; 제주날 점막; ; 직장; ; 십이지장; ; 피; ; 안검결막;
	상단 표시 위치:
	입술; ; 이차 난모세포; ; 식도; ; 모룰라; ; jejunum; ; 배; ; 십이지장; ; 결장; ; 우폐엽; ; 노른자낭;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 결합;
셀룰러 컴포넌트	세포질; 재활용 엔도솜; 내염색체; 식세포 소포막; 막; 세포질 소포; 세포; 세포막내소기관;
생물학적 과정	단백질 수송; 조절성 세포외증; 아디포넥틴 분비 음성 조절;
	출처:아미고 / QuickGO
맞춤법
	80223
	75767
	ENSG00000156675
	ENSMUSG000031488
	Q6WKZ4
	Q9D620
	NM_025151; NM_001002233; NM_001002814
	NM_001080813; NM_029423
	NP_001002814; NP_079427
	NP_001074282; NP_083699
	위키데이터
인간 보기/편집	마우스 표시/편집

Rab11 패밀리 인터랙션 단백질 1(Rab11-FIP1)은 Rab11에 의해 인간에서 암호화되는 단백질이다.FIP1 ^[5]^[6]^[7]유전자

기능.

큰 Rab GTPase 계열의 단백질(예: RAB1A 참조)은 세포 내 수송 소포의 형성, 표적화 및 융합에 조절 역할을 한다.RAB11FIP1은 Rab GTPases와 ^[6]^[7]상호작용하고 조절하는 많은 단백질 중 하나이다.RAB11FIP1은 아디포넥틴 ^[8]밀매의 조절과 지방세포로부터의 방출에 관여하는 신규 단백질로 확인되었다.사람의 체질량지수 증가에 따라 증가하는 RAB11FIP1 발현은 지방세포로부터의 아디포넥틴의 방출을 억제하여 비만인구에서 관찰되는 ^[8]아디포넥틴의 순환 수준을 낮추는 데 잠재적으로 기여한다.

상호 작용

RAB11FIP1은 RAB11A^[5]^[6]^[9] ^[5]및 RAB4A와 상호 작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000156675 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000031488 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW (Apr 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". J Biol Chem. 277 (14): 12190–9. doi:10.1074/jbc.M108665200. PMID 11786538.
^ ^a ^b ^c Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR (Oct 2001). "Identification and characterization of a family of Rab11-interacting proteins". J Biol Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
^ ^a ^b "Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I)".
^ ^a ^b Carson, Brian P.; Maria Del Bas, Josep; Moreno-Navarrete, Jose Maria; Fernandez-Real, Jose Manuel; Mora, Silvia (September 2013). "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLOS ONE. 8 (9): e74687. doi:10.1371/journal.pone.0074687. PMC 3770573. PMID 24040321.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

추가 정보

Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2002). "The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities". Biochem. Biophys. Res. Commun. 292 (4): 909–15. doi:10.1006/bbrc.2002.6736. PMID 11944901.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Thériault C, Rochdi MD, Parent JL (2004). "Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta)". Biochemistry. 43 (19): 5600–7. doi:10.1021/bi036268v. PMID 15134434.
Peden AA, Schonteich E, Chun J, et al. (2005). "The RCP-Rab11 complex regulates endocytic protein sorting". Mol. Biol. Cell. 15 (8): 3530–41. doi:10.1091/mbc.E03-12-0918. PMC 491816. PMID 15181150.
Lindsay AJ, McCaffrey MW (2004). "Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis". FEBS Lett. 571 (1–3): 86–92. doi:10.1016/j.febslet.2004.06.068. PMID 15280022. S2CID 35306314.
Damiani MT, Pavarotti M, Leiva N, et al. (2005). "Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment". Traffic. 5 (10): 785–97. doi:10.1111/j.1600-0854.2004.00220.x. PMID 15355514. S2CID 37310957.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Marie N, Lindsay AJ, McCaffrey MW (2005). "Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner". Biochem. J. 389 (Pt 1): 223–31. doi:10.1042/BJ20042116. PMC 1184555. PMID 15769254.
Tajika Y, Matsuzaki T, Suzuki T, et al. (2006). "Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments". Histochem. Cell Biol. 124 (1): 1–12. doi:10.1007/s00418-005-0010-3. PMID 16049696. S2CID 14746792.
Patil VS, Sachdeva G, Modi DN, et al. (2006). "Rab coupling protein (RCP): a novel target of progesterone action in primate endometrium". J. Mol. Endocrinol. 35 (2): 357–72. doi:10.1677/jme.1.01807. PMID 16216915.
Jin M, Goldenring JR (2006). "The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system". Biochim. Biophys. Acta. 1759 (6): 281–95. doi:10.1016/j.bbaexp.2006.06.001. PMID 16920206.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

인간 염색체 8번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000156675 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000031488 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11786538-5] Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW (Apr 2002). "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein". J Biol Chem. 277 (14): 12190–9. doi:10.1074/jbc.M108665200. PMID 11786538.

[pmid11495908-6] Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR (Oct 2001). "Identification and characterization of a family of Rab11-interacting proteins". J Biol Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.

[entrez-7] "Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I)".

[ncbi.nlm.nih.gov-8] Carson, Brian P.; Maria Del Bas, Josep; Moreno-Navarrete, Jose Maria; Fernandez-Real, Jose Manuel; Mora, Silvia (September 2013). "The Rab11 Effector Protein FIP1 Regulates Adiponectin". PLOS ONE. 8 (9): e74687. doi:10.1371/journal.pone.0074687. PMC 3770573. PMID 24040321.

[pmid17353931-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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RAB11FIP1

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목차

기능.

상호 작용

레퍼런스

추가 정보