단백질 SET

세트
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2E50
식별자
에일리어스	SET, 2PP2A, I2PP2A, IGAAD, IPP2A2, PHII, TAF-I, TAF-IBTA, SET핵원형, MRD58
외부 ID	OMIM : 600960 MGI : 1860267 HomoloGene : 55707 GenCard : SET
유전자 위치(인간)
크르.	9번 염색체(인간)
끝.	128,696,400 bp
유전자 위치(마우스)
크르.	2번 염색체(마우스)
끝.	29,962,589 bp
RNA발현패턴
	상단 표시 위치:
	신경절 융기; ; 아킬레스건; ; 생식 상피; ; 안검결막; ; 림프절; ; 시신경; ; 두정 흉막; ; 내장글로부페리더스; ; 뇌량; ; 흉선;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	DNA결합; 히스톤 결합; GO:0001948 단백질 결합; 단백질인산가수분해효소억제제활성; 단백질인산가수분해효소조절활성;
셀룰러 컴포넌트	세포질; 세포; 핵소체; 소포체; 세포질핵주위영역; 핵; 지질액적; 단백질 함유 복합체;
생물학적 과정	뉴런 아포토시스 과정의 음성 조절; 뉴클레오솜 조립체; mRNA 안정성 조절; DNA복제; 뉴클레오솜 분해; 핵세포질수송; GO:0022415 바이러스 처리; 전사 음성 조절, DNA 템플릿; 히스톤 아세틸화의 음성 조절; GO:0048553 촉매 활성의 음극 조절; GO:0048552 촉매 활성 조절; 인단백인산가수분해효소활성음성조절; 인단백인산가수분해효소활성조절;
	출처:아미고 / QuickGO
맞춤법
	6418
	56086
	ENSG00000119335
	ENSMUSG000054766
	Q01105
	Q9EQ5
	NM_001122821; NM_001248000; NM_001248001; NM_003011; NM_001374326
	NM_001204875; NM_023871
	NP_001116293; NP_001234929; NP_001234930; NP_003002; NP_001361255
	NP_001191804; NP_076360
	위키데이터
인간 보기/편집	마우스 표시/편집

단백질 SET 1로도 알려진 단백질 SET는 SET ^[5]^[6]^[7]유전자에 의해 인간에게 암호화되는 단백질이다.

상호 작용

단백질 SET는 다음 물질과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000119335 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000054766 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene". Molecular and Cellular Biology. 12 (8): 3346–55. doi:10.1128/mcb.12.8.3346. PMC 364582. PMID 1630450.
^ Li M, Makkinje A, Damuni Z (May 1996). "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A". The Journal of Biological Chemistry. 271 (19): 11059–62. doi:10.1074/jbc.271.19.11059. PMID 8626647.
^ "Entrez Gene: SET SET translocation (myeloid leukemia-associated)".
^ ^a ^b Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/s0092-8674(01)00196-9. PMID 11163245. S2CID 11144887.
^ Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology. 22 (8): 2810–20. doi:10.1128/mcb.22.8.2810-2820.2002. PMC 133744. PMID 11909973.
^ Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry. 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.
^ Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/mcb.23.23.8528-8541.2003. PMC 262669. PMID 14612398.
^ Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (Mar 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor". Cell. 112 (5): 659–72. doi:10.1016/s0092-8674(03)00150-8. PMID 12628186. S2CID 14019153.

추가 정보

Nagata K, Kawase H, Handa H, Yano K, Yamasaki M, Ishimi Y, Okuda A, Kikuchi A, Matsumoto K (May 1995). "Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis". Proceedings of the National Academy of Sciences of the United States of America. 92 (10): 4279–83. Bibcode:1995PNAS...92.4279N. doi:10.1073/pnas.92.10.4279. PMC 41927. PMID 7753797.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Adachi Y, Pavlakis GN, Copeland TD (Mar 1994). "Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia". FEBS Letters. 340 (3): 231–5. doi:10.1016/0014-5793(94)80144-4. PMID 8131851. S2CID 36974869.
Vaesen M, Barnikol-Watanabe S, Götz H, Awni LA, Cole T, Zimmermann B, Kratzin HD, Hilschmann N (Feb 1994). "Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII". Biological Chemistry Hoppe-Seyler. 375 (2): 113–26. doi:10.1515/bchm3.1994.375.2.113. PMID 8192856.
Adachi Y, Pavlakis GN, Copeland TD (Jan 1994). "Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia". The Journal of Biological Chemistry. 269 (3): 2258–62. doi:10.1016/S0021-9258(17)42162-4. PMID 8294483.
Adler HT, Nallaseth FS, Walter G, Tkachuk DC (Nov 1997). "HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A". The Journal of Biological Chemistry. 272 (45): 28407–14. doi:10.1074/jbc.272.45.28407. PMID 9353299.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Carlson SG, Eng E, Kim EG, Perlman EJ, Copeland TD, Ballermann BJ (Oct 1998). "Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor". Journal of the American Society of Nephrology. 9 (10): 1873–80. doi:10.1681/ASN.V9101873. PMID 9773788.
Brennan CM, Gallouzi IE, Steitz JA (Oct 2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo". The Journal of Cell Biology. 151 (1): 1–14. doi:10.1083/jcb.151.1.1. PMC 2189805. PMID 11018049.
Shikama N, Chan HM, Krstic-Demonacos M, Smith L, Lee CW, Cairns W, La Thangue NB (Dec 2000). "Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators". Molecular and Cellular Biology. 20 (23): 8933–43. doi:10.1128/MCB.20.23.8933-8943.2000. PMC 86548. PMID 11073993.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245. S2CID 11144887.
Minakuchi M, Kakazu N, Gorrin-Rivas MJ, Abe T, Copeland TD, Ueda K, Adachi Y (Mar 2001). "Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET" (PDF). European Journal of Biochemistry. 268 (5): 1340–51. doi:10.1046/j.1432-1327.2001.02000.x. hdl:2433/150179. PMID 11231286.
Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J (Nov 2001). "Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks". The Journal of Biological Chemistry. 276 (46): 43285–93. doi:10.1074/jbc.M108137200. PMID 11555662.
Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry. 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.
Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology. 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. PMC 133744. PMID 11909973.
Cervoni N, Detich N, Seo SB, Chakravarti D, Szyf M (Jul 2002). "The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing". The Journal of Biological Chemistry. 277 (28): 25026–31. doi:10.1074/jbc.M202256200. PMID 11978794.

이 단백질 관련 기사는 스텁입니다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000119335 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000054766 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1630450-5] von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A, Grosveld G (Aug 1992). "Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene". Molecular and Cellular Biology. 12 (8): 3346–55. doi:10.1128/mcb.12.8.3346. PMC 364582. PMID 1630450.

[pmid8626647-6] Li M, Makkinje A, Damuni Z (May 1996). "The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A". The Journal of Biological Chemistry. 271 (19): 11059–62. doi:10.1074/jbc.271.19.11059. PMID 8626647.

[entrez-7] "Entrez Gene: SET SET translocation (myeloid leukemia-associated)".

[pmid11163245-8] Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (Jan 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/s0092-8674(01)00196-9. PMID 11163245. S2CID 11144887.

[pmid11909973-9] Fan Z, Beresford PJ, Zhang D, Lieberman J (Apr 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology. 22 (8): 2810–20. doi:10.1128/mcb.22.8.2810-2820.2002. PMC 133744. PMID 11909973.

[pmid11741927-10] Qu D, Li Q, Lim HY, Cheung NS, Li R, Wang JH, Qi RZ (Mar 2002). "The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity". The Journal of Biological Chemistry. 277 (9): 7324–32. doi:10.1074/jbc.M107270200. PMID 11741927.

[pmid14612398-11] Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/mcb.23.23.8528-8541.2003. PMC 262669. PMID 14612398.

[pmid12628186-12] Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J (Mar 2003). "Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor". Cell. 112 (5): 659–72. doi:10.1016/s0092-8674(03)00150-8. PMID 12628186. S2CID 14019153.

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단백질 SET

네임스페이스

더

상호 작용

레퍼런스

추가 정보