DNA 유도 RNA 중합효소 II 서브유닛 RPB2는 사람에게서 POLR2B [5] [6] 유전자에 의해 암호화 되는 효소이다.
이 유전자는 진핵생물에서 메신저 RNA를 합성하는 역할을 하는 중합효소인 RNA 중합효소 II의 두 번째로 큰 서브유닛을 암호화합니다. 이 서브유닛은 적어도 두 개의 다른 중합효소 서브유닛과 결합하여 DNA 템플릿과 새로 합성된 [7] RNA 사이의 효소 활성 부위에서 접촉을 유지하는 중합효소 내 구조를 형성합니다.
상호 작용 POLR2B는 POLR2C ,[8] POLR2E ,[8] POLR2H [8] 및 POLR2L 과 [8] 상호 작용하는 것으로 나타났습니다 .
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000047315 - 앙상블 , 2017년 5월 ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000029250 - 앙상블 , 2017년 5월 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ Acker J, Wintzerith M, Vigneron M, Kedinger C (October 1992). "Primary structure of the second largest subunit of human RNA polymerase II (or B)". J Mol Biol . 226 (4): 1295–9. doi :10.1016/0022-2836(92)91071-V . PMID 1518060 . ^ Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (August 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics . 20 (3): 496–9. doi :10.1006/geno.1994.1208 . PMID 8034326 . ^ "Entrez Gene: POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa" . ^ a b c d Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits" . J. Biol. Chem . UNITED STATES. 272 (27): 16815–21. doi :10.1074/jbc.272.27.16815 . ISSN 0021-9258 . PMID 9201987 .
추가 정보 Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci . 5 (1): 24–7. doi :10.1007/BF02253352 . PMID 9570510 . Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation" . Curr. Biol . 8 (13): R447–9. doi :10.1016/S0960-9822(98)70289-1 . PMID 9651670 . S2CID 15480646 . Romano G, Kasten M, De Falco G, et al. (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem . 75 (3): 357–68. doi :10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K . PMID 10536359 . Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life . 51 (3): 175–81. doi :10.1080/152165401753544241 . PMID 11547919 . S2CID 10931640 . Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention" . Med Res Rev . 26 (5): 595–625. doi :10.1002/med.20081 . PMC 7168390 . PMID 16838299 . Harrich D, McMillan N, Munoz L, et al. (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets . 7 (12): 1595–606. doi :10.2174/138945006779025338 . PMID 17168834 . Kato H, Sumimoto H, Pognonec P, et al. (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors" . Genes Dev . 6 (4): 655–66. doi :10.1101/gad.6.4.655 . PMID 1559613 . Southgate C, Zapp ML, Green MR (1990). "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein". Nature . 345 (6276): 640–2. Bibcode :1990Natur.345..640S . doi :10.1038/345640a0 . PMID 2190099 . S2CID 4233742 . Zheng XM, Black D, Chambon P, Egly JM (1990). "Sequencing and expression of complementary DNA for the general transcription factor BTF3". Nature . 344 (6266): 556–9. Bibcode :1990Natur.344..556Z . doi :10.1038/344556a0 . PMID 2320128 . S2CID 4227320 . Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat" . Proc. Natl. Acad. Sci. U.S.A . 92 (16): 7153–7. Bibcode :1995PNAS...92.7153W . doi :10.1073/pnas.92.16.7153 . PMC 41297 . PMID 7638159 . Herrmann CH, Rice AP (1995). "Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor" . J. Virol . 69 (3): 1612–20. doi :10.1128/JVI.69.3.1612-1620.1995 . PMC 188757 . PMID 7853496 . Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 . Keen NJ, Gait MJ, Karn J (1996). "Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex" . Proc. Natl. Acad. Sci. U.S.A . 93 (6): 2505–10. Bibcode :1996PNAS...93.2505K . doi :10.1073/pnas.93.6.2505 . PMC 39827 . PMID 8637904 . Yang X, Herrmann CH, Rice AP (1996). "The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function" . J. Virol . 70 (7): 4576–84. doi :10.1128/JVI.70.7.4576-4584.1996 . PMC 190394 . PMID 8676484 . Agostini I, Navarro JM, Rey F, et al. (1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol . 261 (5): 599–606. doi :10.1006/jmbi.1996.0485 . PMID 8800208 . Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science . 274 (5287): 605–10. Bibcode :1996Sci...274..605Z . doi :10.1126/science.274.5287.605 . PMID 8849451 . S2CID 13266489 . Okamoto H, Sheline CT, Corden JL, et al. (1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II" . Proc. Natl. Acad. Sci. U.S.A . 93 (21): 11575–9. Bibcode :1996PNAS...9311575O . doi :10.1073/pnas.93.21.11575 . PMC 38099 . PMID 8876177 . Chun RF, Jeang KT (1996). "Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1" . J. Biol. Chem . 271 (44): 27888–94. doi :10.1074/jbc.271.44.27888 . PMID 8910388 .