플라스틱 1
PLAGL1
아연 핑거 단백질 PLAGL1은 인간의 PLAGL1 [5][6][7]유전자에 의해 코드되는 단백질이다.
기능.
이 유전자는 C2H2 아연 핑거 단백질을 트랜스활성화 및 DNA 결합 활성으로 암호화합니다.이 유전자는 항증식 활성을 보이는 것으로 나타났으며 종양 억제 유전자 후보이다.이 [7]유전자에 대해 서로 다른 두 개의 아이소폼을 코드하는 많은 전사 변형이 발견되었다.
상호 작용
PLAGL1은 P53과 [8]상호작용하는 것으로 나타났다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000118495 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000019817 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (Oct 1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527.
- ^ Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L (Aug 1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8835–40. Bibcode:1998PNAS...95.8835V. doi:10.1073/pnas.95.15.8835. PMC 21163. PMID 9671765.
- ^ a b "Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1".
- ^ Huang SM, Schönthal AH, Stallcup MR (Apr 2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.
추가 정보
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- Abdollahi A, Roberts D, Godwin AK, Schultz DC, Sonoda G, Testa JR, Hamilton TC (1997). "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors". Oncogene. 14 (16): 1973–9. doi:10.1038/sj.onc.1201034. PMID 9150364.
- Abdollahi A, Godwin AK, Miller PD, Getts LA, Schultz DC, Taguchi T, Testa JR, Hamilton TC (1997). "Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells". Cancer Res. 57 (10): 2029–34. PMID 9158001.
- Spengler D, Villalba M, Hoffmann A, Pantaloni C, Houssami S, Bockaert J, Journot L (1997). "Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain". EMBO J. 16 (10): 2814–25. doi:10.1093/emboj/16.10.2814. PMC 1169890. PMID 9184226.
- Abdollahi A, Bao R, Hamilton TC (1999). "LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein". Oncogene. 18 (47): 6477–87. doi:10.1038/sj.onc.1203067. PMID 10597250.
- Kamiya M, Judson H, Okazaki Y, Kusakabe M, Muramatsu M, Takada S, Takagi N, Arima T, Wake N, Kamimura K, Satomura K, Hermann R, Bonthron DT, Hayashizaki Y (2000). "The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes". Hum. Mol. Genet. 9 (3): 453–60. doi:10.1093/hmg/9.3.453. PMID 10655556.
- Bilanges B, Varrault A, Mazumdar A, Pantaloni C, Hoffmann A, Bockaert J, Spengler D, Journot L (2001). "Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities". Oncogene. 20 (10): 1246–53. doi:10.1038/sj.onc.1204237. PMID 11313869.
- Huang SM, Schönthal AH, Stallcup MR (2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.
- Mackay DJ, Coupe AM, Shield JP, Storr JN, Temple IK, Robinson DO (2002). "Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus". Hum. Genet. 110 (2): 139–44. doi:10.1007/s00439-001-0671-5. PMID 11935319. S2CID 22321580.
- Abdollahi A, Pisarcik D, Roberts D, Weinstein J, Cairns P, Hamilton TC (2003). "LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer". J. Biol. Chem. 278 (8): 6041–9. doi:10.1074/jbc.M210361200. PMID 12473647.
- Hoffmann A, Ciani E, Boeckardt J, Holsboer F, Journot L, Spengler D (2003). "Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding". Mol. Cell. Biol. 23 (3): 988–1003. doi:10.1128/MCB.23.3.988-1003.2003. PMC 140694. PMID 12529403.
- Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin R, Rutter GA, Kelsey G (2004). "Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM". J. Clin. Invest. 114 (3): 339–48. doi:10.1172/JCI19876. PMC 484972. PMID 15286800.
- Cvetkovic D, Pisarcik D, Lee C, Hamilton TC, Abdollahi A (2004). "Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer". Gynecol. Oncol. 95 (3): 449–55. doi:10.1016/j.ygyno.2004.08.051. PMID 15581945.
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