플라스틱 1
PLAGL1아연 핑거 단백질 PLAGL1은 인간의 PLAGL1 [5][6][7]유전자에 의해 코드되는 단백질이다.
기능.
이 유전자는 C2H2 아연 핑거 단백질을 트랜스활성화 및 DNA 결합 활성으로 암호화합니다.이 유전자는 항증식 활성을 보이는 것으로 나타났으며 종양 억제 유전자 후보이다.이 [7]유전자에 대해 서로 다른 두 개의 아이소폼을 코드하는 많은 전사 변형이 발견되었다.
상호 작용
PLAGL1은 P53과 [8]상호작용하는 것으로 나타났다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000118495 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000019817 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (Oct 1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527.
- ^ Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L (Aug 1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8835–40. Bibcode:1998PNAS...95.8835V. doi:10.1073/pnas.95.15.8835. PMC 21163. PMID 9671765.
- ^ a b "Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1".
- ^ Huang SM, Schönthal AH, Stallcup MR (Apr 2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene. 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.
추가 정보
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