호모 사피엔스 종의 단백질 코드 유전자
이 기사는 인간의 PKIA 유전자에 의해 암호화된 단백질에 관한 것이다. 군인 사상자 분류는 전사자를 참조 하십시오. PKIA 사용 가능한 구조 PDB Ortholog 검색: PDBe RCSB PDB ID 코드 목록 1CMK , 1JLU , 1Q8T , 1XH4 , 1XH5 , 1XH6 , 1XH7 , 1XH8 , 1XH9 , 1XHA , 1YDR , 2C1A , 2C1B , 2F7EGN B1 , 4IB3 , 4IE9 , 4IJ9 , 4O21 , 4O22 , 4WB5, 4WB6, 4WB7, 4WB8, 4Z83 , 4Z84 , 5DH9 , 1Q61 , 3X2U , 3X2W , 1Q62
식별자 에일리어스 PKIA 외부 ID OMIM : 606059 MGI : 104747 HomoloGene : 7473 GeneCards : PKIA 맞춤법 종. 인간 마우스 엔트레즈 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 장소(UCSC) Chr 8: 78.52 ~78.61 Mb Chr 3: 7.43 ~7.51 Mb PubMed 검색[3] [4] 위키데이터
cAMP의존성 단백질인산화효소억제제 알파 는 PKIA 유전자에 [5] [6] 단백질 이다.
이 유전자에 의해 코드된 단백질은 cAMP-의존성 단백질인산화효소 (PKA) 억제제 패밀리의 구성원이다. 이 단백질은 PKA의 Cα 및 C 베타 촉매 서브유닛과 상호작용하고 활동을 억제하는 것으로 입증되었다. 동일한 단백질을 코드하는 대체적으로 스플라이스된 전사 변이가 [6]
레퍼런스 추가 정보 Olsen SR, Uhler MD (1991). "Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase" . J. Biol. Chem . 266 (17): 11158–11162. doi :10.1016/S0021-9258(18)99142-8 PMID 1710219 . Knighton DR, Zheng JH, Ten Eyck LF, et al. (1991). "Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase". Science . 253 (5018): 414–420. doi :10.1126/science.1862343 . PMID 1862343 . Van Patten SM, Heisermann GJ, Cheng HC, Walsh DA (1987). "Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase" . J. Biol. Chem . 262 (7): 3398–3403. doi :10.1016/S0021-9258(18)61516-9 PMID 2434500 . Scott JD, Fischer EH, Demaille JG, Krebs EG (1985). "Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase" . Proc. Natl. Acad. Sci. U.S.A . 82 (13): 4379–4383. doi :10.1073/pnas.82.13.4379 PMC 390417 PMID 2989819 . Scott JD, Glaccum MB, Fischer EH, Krebs EG (1986). "Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase" . Proc. Natl. Acad. Sci. U.S.A . 83 (6): 1613–1616. doi :10.1073/pnas.83.6.1613 PMC 323133 PMID 3456605 . Wen W, Taylor SS, Meinkoth JL (1995). "The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated" . J. Biol. Chem . 270 (5): 2041–2046. doi :10.1074/jbc.270.5.2041 PMID 7836431 . Baude EJ, Dignam SS, Olsen SR, et al. (1994). "Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor" . J. Biol. Chem . 269 (3): 2316–2323. doi :10.1016/S0021-9258(17)42170-3 PMID 7905001 . Baude EJ, Dignam SS, Reimann EM, Uhler MD (1994). "Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors" . J. Biol. Chem . 269 (27): 18128–18133. doi :10.1016/S0021-9258(17)32426-2 PMID 8027074 . Fritz CC, Green MR (1997). "HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs" . Curr. Biol . 6 (7): 848–854. doi :10.1016/S0960-9822(02)00608-5 PMID 8805303 . S2CID 16705807 . Zimmermann B, Chiorini JA, Ma Y, et al. (1999). "PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I" . J. Biol. Chem . 274 (9): 5370–5378. doi :10.1074/jbc.274.9.5370 PMID 10026146 . Yu J, Yu L, Chen Z, et al. (2002). "Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors". Brain Res. Mol. Brain Res . 99 (2): 145–149. doi :10.1016/S0169-328X(02)00104-3 . PMID 11978406 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gassel M, Breitenlechner CB, Rüger P, et al. (2003). "Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT)". J. Mol. Biol . 329 (5): 1021–1034. doi :10.1016/S0022-2836(03)00518-7 . PMID 12798691 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . 
