PEX3

PEX3
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	3AJB, 3MK4
식별자
에일리어스	PEX3, PBD10A, TRG18, 페르옥시좀생성인자3, PBD10B
외부 ID	OMIM: 603164 MGI: 1929646 HomoloGene: 2691 GeneCard: PEX3
유전자 위치(인간)
크르.	6번 염색체(인간)
끝.	143,490,616 bp
유전자 위치(마우스)
크르.	10번 염색체(쥐)
끝.	13,428,886 bp
RNA발현패턴
	상단 표시 위치:
	내피 세포; ; 좌부신; ; 난모세포; ; 인간의 음경; ; 신장수질; ; 외음부; ; 간우엽; ; 신장세관; ; 이차 난모세포; ; 아킬레스건;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 이량화 활성; GO:0001948 단백질 결합; 지질 결합; 단백질 고분자 어댑터 활성;
셀룰러 컴포넌트	막의 적분 성분; 세포; 막; 과산화염색체막; 퍼옥시좀; 핵소체; 단백질-지질복합체; 소포체; 과산화염소체막의 적분; 단백질 함유 복합체;
생물학적 과정	페르옥시좀 조직; 페르옥시좀막생성; 페르옥시좀막으로의 단백질 수입; 막 통과 수송;
	출처:아미고 / QuickGO
맞춤법
	8504
	56535
	ENSG000034693
	ENSMUSG000019809
	P56589; Q7Z6V3
	Q9QXY9
	NM_003630
	NM_001164195; NM_0961; NM_001347361
	NP_003621
	NP_001157667; NP_001334290; NP_064345
	위키데이터
인간 보기/편집	마우스 표시/편집

페르옥시좀 생물형성인자 3은 PEX3 ^[5]^[6]유전자에 의해 인체 내에서 부호화되는 단백질이다.

상호 작용

PEX3는 PEX19와 ^[7]^[8]^[9]^[10]상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG000034693 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000019809 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kammerer S, Holzinger A, Welsch U, Roscher AA (Jun 1998). "Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p". FEBS Letters. 429 (1): 53–60. doi:10.1016/S0014-5793(98)00557-2. PMID 9657383. S2CID 33291739.
^ "Entrez Gene: PEX3 peroxisomal biogenesis factor 3".
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (Mar 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochemical and Biophysical Research Communications. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
^ Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (Mar 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
^ Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (Jul 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.

추가 정보

South ST, Gould SJ (Jan 1999). "Peroxisome synthesis in the absence of preexisting peroxisomes". The Journal of Cell Biology. 144 (2): 255–66. doi:10.1083/jcb.144.2.255. PMC 2132891. PMID 9922452.
Soukupova M, Sprenger C, Gorgas K, Kunau WH, Dodt G (Jun 1999). "Identification and characterization of the human peroxin PEX3". European Journal of Cell Biology. 78 (6): 357–74. doi:10.1016/S0171-9335(99)80078-8. PMID 10430017.
Muntau AC, Holzinger A, Mayerhofer PU, Gärtner J, Roscher AA, Kammerer S (Feb 2000). "The human PEX3 gene encoding a peroxisomal assembly protein: genomic organization, positional mapping, and mutation analysis in candidate phenotypes". Biochemical and Biophysical Research Communications. 268 (3): 704–10. doi:10.1006/bbrc.2000.2193. PMID 10679269.
Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (Mar 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
Ghaedi K, Tamura S, Okumoto K, Matsuzono Y, Fujiki Y (Jun 2000). "The peroxin pex3p initiates membrane assembly in peroxisome biogenesis". Molecular Biology of the Cell. 11 (6): 2085–102. doi:10.1091/mbc.11.6.2085. PMC 14905. PMID 10848631.
Muntau AC, Mayerhofer PU, Paton BC, Kammerer S, Roscher AA (Oct 2000). "Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G". American Journal of Human Genetics. 67 (4): 967–75. doi:10.1086/303071. PMC 1287898. PMID 10958759.
Ghaedi K, Honsho M, Shimozawa N, Suzuki Y, Kondo N, Fujiki Y (Oct 2000). "PEX3 is the causal gene responsible for peroxisome membrane assembly-defective Zellweger syndrome of complementation group G". American Journal of Human Genetics. 67 (4): 976–81. doi:10.1086/303086. PMC 1287899. PMID 10968777.
Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (Jul 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.
Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (Mar 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochemical and Biophysical Research Communications. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
Fransen M, Brees C, Ghys K, Amery L, Mannaerts GP, Ladant D, Van Veldhoven PP (Mar 2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Molecular & Cellular Proteomics. 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
Muntau AC, Roscher AA, Kunau WH, Dodt G (Jul 2003). "The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis". European Journal of Cell Biology. 82 (7): 333–42. doi:10.1078/0171-9335-00325. PMID 12924628.
Muntau AC, Roscher AA, Kunau WH, Dodt G (2004). "Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET)". Peroxisomal Disorders and Regulation of Genes. Advances in Experimental Medicine and Biology. Vol. 544. pp. 221–4. doi:10.1007/978-1-4419-9072-3_27. ISBN 978-1-4613-4782-8. PMID 14713233.
Fang Y, Morrell JC, Jones JM, Gould SJ (Mar 2004). "PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins". The Journal of Cell Biology. 164 (6): 863–75. doi:10.1083/jcb.200311131. PMC 2172291. PMID 15007061.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Matsuzono Y, Matsuzaki T, Fujiki Y (Sep 2006). "Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation". Journal of Cell Science. 119 (Pt 17): 3539–50. doi:10.1242/jcs.03100. PMID 16895967.

외부 링크

인간 염색체 6번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG000034693 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000019809 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9657383-5] Kammerer S, Holzinger A, Welsch U, Roscher AA (Jun 1998). "Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p". FEBS Letters. 429 (1): 53–60. doi:10.1016/S0014-5793(98)00557-2. PMID 9657383. S2CID 33291739.

[entrez-6] "Entrez Gene: PEX3 peroxisomal biogenesis factor 3".

[pmid16189514-7] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid11883941-8] Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (Mar 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochemical and Biophysical Research Communications. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.

[pmid10704444-9] Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (Mar 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.

[pmid11390669-10] Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (Jul 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

Search

PEX3

네임스페이스

더

목차

상호 작용

레퍼런스

추가 정보

외부 링크