NME2
NME2
뉴클레오시드2인산인산화효소B는 사람에게서 NME2 유전자에 [5][6]의해 암호화되는 효소이다.
기능.
뉴클레오시드2인산인산화효소(NDK)는 A(NME1로 암호화)와 B(이 유전자에 의해 암호화됨) 이소형식으로 이루어진 헥사머로서 존재한다.이 유전자에 대해 동일한 아이소폼을 코드하는 복수의 대체 스플라이스 전사 변이가 발견되었다.이 유전자와 인접 업스트림 유전자(NME1)의 동시전사는 각각의 개별 유전자 [6]생성물과의 배열을 공유하는 동일성으로 이루어진 융합단백질을 코드하는 자연발생 전사물(NME1-NME2)을 생성한다.
상호 작용
NME2는 NME3[7][8] 및 HERC5와 [9]상호작용하는 것으로 나타났습니다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000243678 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000020857 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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- ^ a b "Entrez Gene: NME2 non-metastatic cells 2, protein (NM23B) expressed in".
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- ^ Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679.
- ^ Hochrainer K, Kroismayr R, Baranyi U, Binder BR, Lipp J (July 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell. Mol. Life Sci. 65 (13): 2105–17. doi:10.1007/s00018-008-8148-5. PMID 18535780. S2CID 6897759.
추가 정보
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