NCKAP1

NCKAP1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	3P8C, 4N78
식별자
에일리어스	NCKAP1, HEM2, NAP1, NAP125, p125Nap1, NCK 관련 단백질 1
외부 ID	OMIM: 604891 MGI: 1355333 HomoloGene: 8384 GenCard: NCKAP1
유전자 위치(인간)
크르.	2번 염색체(인간)
끝.	183,038,858 bp
유전자 위치(마우스)
크르.	2번 염색체(마우스)
끝.	80,411,724 bp
RNA발현패턴
	상단 표시 위치:
	정낭포; ; 전두극; ; 소뇌충; ; 신경절 융기; ; 구강; ; 안와전두피질; ; 유즙관; ; 제주날 점막; ; 아킬레스건; ; 인간의 음경;
	상단 표시 위치:
	해마의 고유 영역 I; ; 대상회; ; 편도체; ; 고유 해마; ; 일차 운동 피질; ; 흑색 실체; ; 후결절; ; 각막 간질; ; 전전두피질; ; 장피질;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 함유 복합 결합; 단백질 결합;
셀룰러 컴포넌트	막의 적분 성분; 세포; 세포 투영; 막; SCAR 착화체; 국소 접착; 혈장막; 세포외 엑소좀; 층상 지방막; 흔들리다; 라멜리포듐; 필라멘트 액틴;
생물학적 과정	식세포증에 관여하는 Fc-gamma 수용체 시그널링 경로; Arp2/3 복합 매개 액틴 핵형성의 양성 조절; 중추 신경계의 발달; 혈관내피증식인자수용체신호경로; Rac 단백질 신호 전달; 바이러스 과정; 아포토시스 과정; 라멜리포듐 조립체 양성 조절; 액틴 필라멘트 중합 양성 조절; 세포형태형성; 세포이동; 세포투영조립체; 피질액틴세포골격조직; 뉴런 투영 형태 형성;
	출처:아미고 / QuickGO
맞춤법
	10787
	50884
	ENSG000061676
	ENSMUSG000027002
	Q9Y2A7
	P28660
	NM_013436; NM_205842
	NM_001290745; NM_016965; NM_001355410; NM_001355411
	NP_038464; NP_995314
	NP_001277674; NP_05861; NP_001342339; NP_001342340
	위키데이터
인간 보기/편집	마우스 표시/편집

Nck관련단백질1은 NCKAP1유전자에 ^[5]^[6]^[7]^[8]의해 인체 내에서 코드되는 단백질이다.

상호 작용

NCKAP1은 RAC1 및 ABI1과 ^[10]상호^[9] 작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG000061676 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000027002 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Suzuki T, Nishiyama K, Yamamoto A, Inazawa J, Iwaki T, Yamada T, Kanazawa I, Sakaki Y (Jan 2000). "Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease". Genomics. 63 (2): 246–54. doi:10.1006/geno.1999.6053. PMID 10673335.
^ Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW (Aug 2002). "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck". Nature. 418 (6899): 790–3. Bibcode:2002Natur.418..790E. doi:10.1038/nature00859. PMID 12181570. S2CID 4350733.
^ Matuoka K, Miki H, Takahashi K, Takenawa T (Oct 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications. 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857.
^ "Entrez Gene: NCKAP1 NCK-associated protein 1".
^ Kitamura Y, Kitamura T, Sakaue H, Maeda T, Ueno H, Nishio S, Ohno S, Osada SI, Sakaue M, Ogawa W, Kasuga M (Mar 1997). "Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac". The Biochemical Journal. 322 (Pt 3): 873–8. doi:10.1042/bj3220873. PMC 1218269. PMID 9148763.
^ Yamamoto A, Suzuki T, Sakaki Y (Jun 2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene. 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237.

추가 정보

Kitamura T, Kitamura Y, Yonezawa K, Totty NF, Gout I, Hara K, Waterfield MD, Sakaue M, Ogawa W, Kasuga M (Feb 1996). "Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck". Biochemical and Biophysical Research Communications. 219 (2): 509–14. doi:10.1006/bbrc.1996.0264. PMID 8605018.
Kobayashi K, Kuroda S, Fukata M, Nakamura T, Nagase T, Nomura N, Matsuura Y, Yoshida-Kubomura N, Iwamatsu A, Kaibuchi K (Jan 1998). "p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase". The Journal of Biological Chemistry. 273 (1): 291–5. doi:10.1074/jbc.273.1.291. PMID 9417078.
Witke W, Podtelejnikov AV, Di Nardo A, Sutherland JD, Gurniak CB, Dotti C, Mann M (Feb 1998). "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly". The EMBO Journal. 17 (4): 967–76. doi:10.1093/emboj/17.4.967. PMC 1170446. PMID 9463375.
Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
Yamamoto A, Suzuki T, Sakaki Y (Jun 2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene. 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237.
Salazar MA, Kwiatkowski AV, Pellegrini L, Cestra G, Butler MH, Rossman KL, Serna DM, Sondek J, Gertler FB, De Camilli P (Dec 2003). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". The Journal of Biological Chemistry. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M (Nov 2003). "Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling". Molecular and Cellular Biology. 23 (21): 7780–93. doi:10.1128/MCB.23.21.7780-7793.2003. PMC 207563. PMID 14560022.
Innocenti M, Zucconi A, Disanza A, Frittoli E, Areces LB, Steffen A, Stradal TE, Di Fiore PP, Carlier MF, Scita G (Apr 2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex". Nature Cell Biology. 6 (4): 319–27. doi:10.1038/ncb1105. PMID 15048123. S2CID 22767022.
Mayne M, Moffatt T, Kong H, McLaren PJ, Fowke KR, Becker KG, Namaka M, Schenck A, Bardoni B, Bernstein CN, Melanson M (Apr 2004). "CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion". European Journal of Immunology. 34 (4): 1217–27. doi:10.1002/eji.200324726. PMID 15048733.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Chen W, Tang Z, Fortina P, Patel P, Addya S, Surrey S, Acheampong EA, Mukhtar M, Pomerantz RJ (Mar 2005). "Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways". Virology. 334 (1): 59–73. doi:10.1016/j.virol.2005.01.014. PMID 15749123.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

인간 염색체 2번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG000061676 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000027002 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10673335-5] Suzuki T, Nishiyama K, Yamamoto A, Inazawa J, Iwaki T, Yamada T, Kanazawa I, Sakaki Y (Jan 2000). "Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease". Genomics. 63 (2): 246–54. doi:10.1006/geno.1999.6053. PMID 10673335.

[pmid12181570-6] Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW (Aug 2002). "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck". Nature. 418 (6899): 790–3. Bibcode:2002Natur.418..790E. doi:10.1038/nature00859. PMID 12181570. S2CID 4350733.

[pmid9344857-7] Matuoka K, Miki H, Takahashi K, Takenawa T (Oct 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications. 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857.

[entrez-8] "Entrez Gene: NCKAP1 NCK-associated protein 1".

[pmid9148763-9] Kitamura Y, Kitamura T, Sakaue H, Maeda T, Ueno H, Nishio S, Ohno S, Osada SI, Sakaue M, Ogawa W, Kasuga M (Mar 1997). "Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac". The Biochemical Journal. 322 (Pt 3): 873–8. doi:10.1042/bj3220873. PMC 1218269. PMID 9148763.

[pmid11418237-10] Yamamoto A, Suzuki T, Sakaki Y (Jun 2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene. 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237.

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NCKAP1

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상호 작용

레퍼런스

추가 정보