단백질 AF-9 는 인간에게 MLLT3 유전자 에 의해 암호화된 단백질 이다.[5] [6] [7]
상호작용 MLLT3는 BCOR 와 상호작용 하는 것으로 나타났다.[8]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000171843 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000028496 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, et al. (Jul 1993). "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs" . Proc Natl Acad Sci U S A . 90 (10): 4631–5. Bibcode :1993PNAS...90.4631N . doi :10.1073/pnas.90.10.4631 PMC 46566 PMID 8506309 . ^ Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R (Nov 1993). "MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13". Oncogene . 8 (11): 3085–92. PMID 8414510 . ^ "Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3" .^ Srinivasan, R Sathish; de Erkenez Andrea C; Hemenway Charles S (May 2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor" . Oncogene . 22 (22): 3395–406. doi :10.1038/sj.onc.1206361 ISSN 0950-9232 . PMID 12776190 .
추가 읽기 Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Huynh KD, Fischle W, Verdin E, Bardwell VJ (2000). "BCoR, a novel corepressor involved in BCL-6 repression" . Genes Dev . 14 (14): 1810–23. doi :10.1101/gad.14.14.1810 . PMC 316791 PMID 10898795 . García-Cuéllar MP, Zilles O, Schreiner SA, et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3" . Oncogene . 20 (4): 411–9. doi :10.1038/sj.onc.1204108 PMID 11313972 . Hemenway CS, de Erkenez AC, Gould GC (2001). "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias" . Oncogene . 20 (29): 3798–805. doi :10.1038/sj.onc.1204478 PMID 11439343 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Srinivasan RS, de Erkenez AC, Hemenway CS (2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor" . Oncogene . 22 (22): 3395–406. doi :10.1038/sj.onc.1206361 PMID 12776190 . Erfurth F, Hemenway CS, de Erkenez AC, Domer PH (2004). "MLL fusion partners AF4 and AF9 interact at subnuclear foci" . Leukemia . 18 (1): 92–102. doi :10.1038/sj.leu.2403200 PMID 14603337 . Montemurro L, Tonelli R, Fazzina R, et al. (2004). "Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line". Cancer Genet. Cytogenet . 154 (1): 96–7. doi :10.1016/j.cancergencyto.2004.01.029 . PMID 15381384 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Martino V, Tonelli R, Montemurro L, et al. (2006). "Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23)" . Oncol. Rep . 15 (1): 207–11. doi :10.3892/or.15.1.207 PMID 16328057 .
