호모 사피엔스 종의 단백질 코드 유전자
RNA중합효소II 전사 서브유닛14의 매개체 는 MED14 [5] [6] [7] 효소 이다.
유전자 전사의 활성화는 DNA에서 전사증강제 부위를 인식하는 인자에 의해 촉발되는 다단계 과정이다. 이러한 인자는 RNA 중합효소 II 장치에 의한 전사 개시를 지시하기 위해 공동 활성제와 함께 작동합니다. 이 유전자에 의해 코드된 단백질은 SP1 활성화에 필요한 보조인자(CRSP) 복합체의 서브유닛으로, TFIID와 함께 SP1에 의한 효율적인 활성화에 필요하다. 이 단백질은 또한 TR과 상호작용하고 개시 인자 및 보조 인자와 함께 DNA 템플릿에서 TR 기능을 촉진하는 갑상선 호르몬 수용체(TR-) 관련 단백질과 같은 다른 다중 서브유닛 복합체의 구성요소이다. 이 단백질에는 초당적인 핵 국재 신호가 포함되어 있습니다. 이 유전자는 염색체 X [7]
상호 작용 MED14는 PPARGC1A ,[8] 에스트로겐 수용체 알파,[9] STAT2 ,[10] 사이클린 의존성 키나제 [11] [12] 글루코코르티코이드 [13] 간세포 핵인자 4 [14] [15] 것 으로 나타났다.
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