호모 사피엔스 종의 단백질 코드 유전자
U6 snRNA 관련 Sm 유사 단백질 LSm7 은 LSM7 [5] [6] [7] 단백질 이다.
기능. Sm 단백질 패밀리와의 배열 상동성을 기반으로 다양한 유기체에서 Sm 유사 단백질이 확인되었다(SNRPD2; MIM 601061 참조). Sm 유사 단백질은 루프로 접히는 가변 길이의 링커에 의해 분리된 2개의 영역으로 구성된 Sm 배열 모티브를 포함한다. Sm 유사 단백질은 tri-snRNP 입자에 존재하는 안정적인 헤테로머를 형성하는 것으로 생각되며, 이는 mRNA 전 스플라이싱에 중요하다. [OMIM [7]
상호 작용 LSM7은 TACC1 [8] [9] LSM2 와 [10] [11] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000130332 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000035215 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Lührmann R (Oct 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro" . The EMBO Journal . 18 (20): 5789–802. doi :10.1093/emboj/18.20.5789 . PMC 1171645 PMID 10523320 . ^ Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (Dec 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci" . RNA . 8 (12): 1489–501. doi :10.1017/S1355838202021726 (inactive 28 February 2022). PMC 1370355 PMID 12515382 . {{cite journal }}: CS1 유지 : 2022년 2월 현재 DOI 비활성화 (링크 ) ^ a b "Entrez Gene: LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)" .^ Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer" . Oncogene . 22 (50): 8102–16. doi :10.1038/sj.onc.1206972 PMID 14603251 . ^ Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators" . Oncogene . 21 (36): 5619–30. doi :10.1038/sj.onc.1205658 PMID 12165861 . ^ Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation" . Genome Research . 14 (7): 1315–23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . ^ Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics . 83 (1): 153–67. doi :10.1016/S0888-7543(03)00235-0 . PMID 14667819 . 추가 정보 Friesen WJ, Dreyfuss G (Aug 2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)" . The Journal of Biological Chemistry . 275 (34): 26370–5. doi :10.1074/jbc.M003299200 PMID 10851237 . Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs" . Genome Research . 11 (10): 1758–65. doi :10.1101/gr.180101 . PMC 311163 PMID 11591653 . Eystathioy T, Peebles CL, Hamel JC, Vaughn JH, Chan EK (Mar 2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera" . Arthritis and Rheumatism . 46 (3): 726–34. doi :10.1002/art.10220 PMID 11920408 . Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators" . Oncogene . 21 (36): 5619–30. doi :10.1038/sj.onc.1205658 PMID 12165861 . Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer" . Oncogene . 22 (50): 8102–16. doi :10.1038/sj.onc.1206972 PMID 14603251 . Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics . 83 (1): 153–67. doi :10.1016/S0888-7543(03)00235-0 . PMID 14667819 . Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation" . Genome Research . 14 (7): 1315–23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Stanĕk D, Neugebauer KM (Sep 2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer" . The Journal of Cell Biology . 166 (7): 1015–25. doi :10.1083/jcb.200405160 . PMC 2172029 PMID 15452143 .
