호모 사피엔스 종의 단백질 코드 유전자
류신 이 풍부한 반복 함유 단백질 8E 는 LRRC8E [5] 유전자 에 의해 인체 내에서 암호화되는 단백질 이다.연구자들은 이 단백질이 다른 LRRC8A , LRRC8B , LRRC8C 및 LRRC8D 와 함께 때로는 헤테로머 단백질 부피 조절 음이온 채널의 [6] 부피 조절 음이온 채널(VRACs)은 염화물 이온과 타우린이나 글루탐산염과 같은 다양한 유기 삼투압을 혈장 [7]
LRRC8E는 VRAC의 일부가 될 수 있는 많은 단백질 중 하나이지만, LRRC8A 및 LRRC8D 에 [8] [9] [10] 그러나 LRRC8A 와 LRRC8D 가 VRAC 기능을 위해 필요하다는 것을 알고 있지만, 다른 연구 결과에서는 일반적인 VRAC [11] LRRC8E와 같은 다른 LRRC8 단백질은 이러한 서브유닛의 다른 구성이 VRAC의 [12] [10]
LRRC8 단백질군은 VRACs에서의 역할 외에도 무감마글로불린혈증-5 와 [13]
특히 LRRC8E의 경우, 이 유전자가 명목상 공황 [14]
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