롬보틴-1 은 인간에게 LMO1 유전자 에 의해 암호화된 단백질 이다.[5] [6] [7]
LMO1은 두 개의 LIM 도메인 전사 조절기를 인코딩한다. 11번 염색체에서 일관된 염색체 변환 영역에 매핑되어 T-세포 백혈병에서는 교란되지만 관련 유전자 LMO2는 교란된다.[7]
상호작용 LMO1은 GATA3 [8] [9] 및 TAL1 과 상호작용 하는 것으로 나타났다.[10] [11]
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000166407 - 앙상블 , 2017년 5월 ^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG00000036111 - 앙상블 , 2017년 5월 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (June 1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13" . Proc Natl Acad Sci U S A . 88 (10): 4367–71. Bibcode :1991PNAS...88.4367B . doi :10.1073/pnas.88.10.4367 . PMC 51660 . PMID 2034676 . ^ McGuire EA, Davis AR, Korsmeyer SJ (March 1991). "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells" . Blood . 77 (3): 599–606. doi :10.1182/blood.V77.3.599.599 . PMID 1703797 . ^ a b "Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)" . ^ Ono, Y; Fukuhara N; Yoshie O (December 1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3" . Mol. Cell. Biol . 18 (12): 6939–50. doi :10.1128/MCB.18.12.6939 . ISSN 0270-7306 . PMC 109277 . PMID 9819382 . ^ Ono, Y; Fukuhara N; Yoshie O (February 1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL" . J. Biol. Chem . 272 (7): 4576–81. doi :10.1074/jbc.272.7.4576 . ISSN 0021-9258 . PMID 9020185 . ^ Valge-Archer, V E; Osada H; Warren A J; Forster A; Li J; Baer R; Rabbitts T H (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells" . Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode :1994PNAS...91.8617V . doi :10.1073/pnas.91.18.8617 . ISSN 0027-8424 . PMC 44657 . PMID 8078932 . ^ Wadman, I; Li J; Bash R O; Forster A; Osada H; Rabbitts T H; Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia" . EMBO J . 13 (20): 4831–9. doi :10.1002/j.1460-2075.1994.tb06809.x . ISSN 0261-4189 . PMC 395422 . PMID 7957052 .
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