1을 포함한 LINE-1형 트랜스포사제 도메인은 L1TD1이라고도 하며, 분화되지 않은 인간 배아줄기세포의 자가갱신과 암세포 증식에 관여하는 RNA 결합 단백질이다.L1TD1은 여러 암의 발병과 관련이 있는 것으로 보고되었다.[3] [4] [5] [6]
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000240563 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S (May 2011). "ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency". PLOS ONE. 6 (5): e20461. Bibcode:2011PLoSO...620461I. doi:10.1371/journal.pone.0020461. PMC 3102727. PMID 21637830.
- ^ Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R (March 2012). "RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation". Stem Cells. 30 (3): 452–60. doi:10.1002/stem.1013. PMC 3507993. PMID 22162396.
- ^ Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ (April 2011). "L1TD1 is a marker for undifferentiated human embryonic stem cells". PLOS ONE. 6 (4): e19355. Bibcode:2011PLoSO...619355W. doi:10.1371/journal.pone.0019355. PMC 3084827. PMID 21559406.
- ^ Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y (October 2008). "LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis". Cancer Epidemiol Biomarkers Prev. 17 (10): 2555–64. doi:10.1158/1055-9965.EPI-08-0112. PMID 18842996.
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