교차점 1

ITSN1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1KI1, 2KGR, 2KHN, 3QBV, 4IIM
식별자
에일리어스	ITSN1, ITSN, SH3D1A, SH3P17, 교차점 1
외부 ID	OMIM: 602442 MGI: 1338069 HomoloGene: 2277 GenCard: ITSN1
유전자 위치(인간)
크르.	21번 염색체(인간)
끝.	33,899,861 bp
유전자 위치(마우스)
크르.	16번 염색체(쥐)
끝.	91,717,485 bp
RNA발현패턴
	상단 표시 위치:
	상부 신경; ; 경골; ; 복정맥; ; 두정 흉막; ; 시신경; ; 지방 조직; ; 심막; ; 피하 지방 조직; ; 복부 지방; ; 신경절 융기;
	상단 표시 위치:
	섬모체; ; 원시적 특징; ; 적란 세포; ; 좌골 신경; ; 안마근; ; 혀 윗면; ; 홍채; ; 이차 난모세포; ; 족저근; ; 담낭;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	칼슘 이온 결합; 금속 이온 결합; 단백질 결합; 키나아제활성화인자활성; 분자 어댑터 활성; 프롤린이 풍부한 영역 결합; 구아닐-플루오르화물교환인자활성;
셀룰러 컴포넌트	세포; 세포 투영; 막; 혈장막; 세포내 소포; 시냅스; 세포 접합; 뉴런 투영; 클라트린 피팅; 내막계; 라멜리포듐; 홀드의 캘릭스; 시냅스전내구대; 핵; 핵외피; 세포질; 내염색체; 세포질 소포; 재활용 엔도솜; 신경세포체; 수상척추; 꼭대기 수상돌기; 세포내 소포; 시냅스 후 세포골격; 글루탐산성 시냅스;
생물학적 과정	뉴런 아포토시스 과정의 음성 조절; 단백질인산화효소B신호전달양성조절; 세포내 신호 전달; 엔도사이토증; 에프린수용체신호경로; 시냅스 소포내구증; 아포토시스 과정의 양성 조절; 인산화 양성 조절; Rho단백질신호전달조절; 소량 GTPase 매개 신호 전달 조절; GTPase 매개 신호 전달; 막구성; 바이러스 과정; G단백질결합수용체신호경로; 키나아제 활성의 양성 조절; 세포외부증; 단백질 수송; 뇌의 발달; 성장호르몬 분비의 양성 조절; 수상 척추 발달의 양성 조절; 세포골격 시냅스 후 작용의 수식 조절; 카보올린-유도내구증 양성조절; GTPase 활성의 양성 조절;
	출처:아미고 / QuickGO
맞춤법
	6453
	16443
	ENSG00000205726
	ENSMUSG000022957
	문제 15811; Q6J334
	Q9Z0R4
NM_001001132; NM_003024; NM_001331008; NM_001331009; NM_001331010;
	NM_001331011; NM_001331012
	NM_001110275; NM_001110276; NM_010587
NP_001001132; NP_001317937; NP_001317938; NP_001317939; NP_001317940;
	NP_001317941; NP_003015
	NP_001103745; NP_001103746; NP_034717
	위키데이터
인간 보기/편집	마우스 표시/편집

크로스신-1은 인간에서 ITSN1 ^[5]^[6]유전자에 의해 암호화되는 단백질이다.

기능.

이 유전자에 의해 코드된 단백질은 세포질막 관련 단백질로 액틴 조립 기계와 간접적으로 세포질막 트래픽을 조정한다.또한 코드화된 단백질은 클라트린 피복 소포의 형성을 조절하고 시냅스 소포 재활용에 관여할 수 있다.이 단백질은 dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, STN2와 상호작용하는 것으로 나타났으며, 이 유전자에 대해 서로 다른 Isoform을 코드하는 여러 전사 변이체가 발견되었지만,^[7] 지금까지 이들 중 2개만 전장 성질이 특징지어졌다.

상호 작용

ITSN1은 다음과 상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000205726 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000022957 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Guipponi M, Scott HS, Chen H, Schebesta A, Rossier C, Antonarakis SE (Nov 1998). "Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon". Genomics. 53 (3): 369–76. doi:10.1006/geno.1998.5521. PMID 9799604.
^ Yamabhai M, Hoffman NG, Hardison NL, McPherson PS, Castagnoli L, Cesareni G, Kay BK (Nov 1998). "Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains". The Journal of Biological Chemistry. 273 (47): 31401–7. doi:10.1074/jbc.273.47.31401. PMID 9813051.
^ "Entrez Gene: ITSN1 intersectin 1 (SH3 domain protein)".
^ Hussain NK, Jenna S, Glogauer M, Quinn CC, Wasiak S, Guipponi M, Antonarakis SE, Kay BK, Stossel TP, Lamarche-Vane N, McPherson PS (Oct 2001). "Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP". Nature Cell Biology. 3 (10): 927–32. doi:10.1038/ncb1001-927. PMID 11584276. S2CID 22914248.
^ Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10.1038/nsb796. PMID 12006984. S2CID 13161854.
^ Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (Apr 2000). "SCAMP1 function in endocytosis". The Journal of Biological Chemistry. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.
^ Okamoto M, Schoch S, Südhof TC (Jun 1999). "EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?". The Journal of Biological Chemistry. 274 (26): 18446–54. doi:10.1074/jbc.274.26.18446. PMID 10373452.
^ Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS (Mar 2000). "The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain". The EMBO Journal. 19 (6): 1263–71. doi:10.1093/emboj/19.6.1263. PMC 305667. PMID 10716926.

추가 정보

Keating DJ, Chen C, Pritchard MA (Nov 2006). "Alzheimer's disease and endocytic dysfunction: clues from the Down syndrome-related proteins, DSCR1 and ITSN1". Ageing Research Reviews. 5 (4): 388–401. doi:10.1016/j.arr.2005.11.001. PMID 16442855. S2CID 12867672.
Chen H, Antonarakis SE (1998). "The SH3D1A gene maps to human chromosome 21q22.1-->q22.2". Cytogenetics and Cell Genetics. 78 (3–4): 213–5. doi:10.1159/000134659. PMID 9465890.
Sparks AB, Hoffman NG, McConnell SJ, Fowlkes DM, Kay BK (Jun 1996). "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins". Nature Biotechnology. 14 (6): 741–4. doi:10.1038/nbt0696-741. PMID 9630982. S2CID 11166026.
Sengar AS, Wang W, Bishay J, Cohen S, Egan SE (Mar 1999). "The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15". The EMBO Journal. 18 (5): 1159–71. doi:10.1093/emboj/18.5.1159. PMC 1171207. PMID 10064583.
Guipponi M, Scott HS, Hattori M, Ishii K, Sakaki Y, Antonarakis SE (1999). "Genomic structure, sequence, and refined mapping of the human intersectin gene (ITSN), which encompasses 250 kb on chromosome 21q22.1-->q22.2". Cytogenetics and Cell Genetics. 83 (3–4): 218–20. doi:10.1159/000015182. PMID 10072581. S2CID 27453719.
Okamoto M, Schoch S, Südhof TC (Jun 1999). "EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?". The Journal of Biological Chemistry. 274 (26): 18446–54. doi:10.1074/jbc.274.26.18446. PMID 10373452.
Pucharcós C, Fuentes JJ, Casas C, de la Luna S, Alcántara S, Arbonés ML, Soriano E, Estivill X, Pritchard M (Sep 1999). "Alu-splice cloning of human Intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome". European Journal of Human Genetics. 7 (6): 704–12. doi:10.1038/sj.ejhg.5200356. PMID 10482960.
Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS (Mar 2000). "The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain". The EMBO Journal. 19 (6): 1263–71. doi:10.1093/emboj/19.6.1263. PMC 305667. PMID 10716926.
Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (Apr 2000). "SCAMP1 function in endocytosis". The Journal of Biological Chemistry. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.
Pucharcos C, Estivill X, de la Luna S (Jul 2000). "Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis". FEBS Letters. 478 (1–2): 43–51. doi:10.1016/S0014-5793(00)01793-2. PMID 10922467. S2CID 24683452.
Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (May 2001). "Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery". The Journal of Cell Biology. 153 (5): 1111–20. doi:10.1083/jcb.153.5.1111. PMC 2174325. PMID 11381094.
Hussain NK, Jenna S, Glogauer M, Quinn CC, Wasiak S, Guipponi M, Antonarakis SE, Kay BK, Stossel TP, Lamarche-Vane N, McPherson PS (Oct 2001). "Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP". Nature Cell Biology. 3 (10): 927–32. doi:10.1038/ncb1001-927. PMID 11584276. S2CID 22914248.
Pucharcos C, Casas C, Nadal M, Estivill X, de la Luna S (Oct 2001). "The human intersectin genes and their spliced variants are differentially expressed". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1521 (1–3): 1–11. doi:10.1016/s0167-4781(01)00276-7. PMID 11690630.
Jenna S, Hussain NK, Danek EI, Triki I, Wasiak S, McPherson PS, Lamarche-Vane N (Feb 2002). "The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin". The Journal of Biological Chemistry. 277 (8): 6366–73. doi:10.1074/jbc.M105516200. PMID 11744688.
Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10.1038/nsb796. PMID 12006984. S2CID 13161854.
Irie F, Yamaguchi Y (Nov 2002). "EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP". Nature Neuroscience. 5 (11): 1117–8. doi:10.1038/nn964. PMID 12389031. S2CID 130279.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000205726 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000022957 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9799604-5] Guipponi M, Scott HS, Chen H, Schebesta A, Rossier C, Antonarakis SE (Nov 1998). "Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon". Genomics. 53 (3): 369–76. doi:10.1006/geno.1998.5521. PMID 9799604.

[pmid9813051-6] Yamabhai M, Hoffman NG, Hardison NL, McPherson PS, Castagnoli L, Cesareni G, Kay BK (Nov 1998). "Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains". The Journal of Biological Chemistry. 273 (47): 31401–7. doi:10.1074/jbc.273.47.31401. PMID 9813051.

[entrez-7] "Entrez Gene: ITSN1 intersectin 1 (SH3 domain protein)".

[pmid11584276-8] Hussain NK, Jenna S, Glogauer M, Quinn CC, Wasiak S, Guipponi M, Antonarakis SE, Kay BK, Stossel TP, Lamarche-Vane N, McPherson PS (Oct 2001). "Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP". Nature Cell Biology. 3 (10): 927–32. doi:10.1038/ncb1001-927. PMID 11584276. S2CID 22914248.

[pmid12006984-9] Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10.1038/nsb796. PMID 12006984. S2CID 13161854.

[pmid10777571-10] Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (Apr 2000). "SCAMP1 function in endocytosis". The Journal of Biological Chemistry. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.

[pmid10373452-11] Okamoto M, Schoch S, Südhof TC (Jun 1999). "EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?". The Journal of Biological Chemistry. 274 (26): 18446–54. doi:10.1074/jbc.274.26.18446. PMID 10373452.

[pmid10716926-12] Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS (Mar 2000). "The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain". The EMBO Journal. 19 (6): 1263–71. doi:10.1093/emboj/19.6.1263. PMC 305667. PMID 10716926.

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교차점 1

네임스페이스

더

목차

기능.

상호 작용

레퍼런스

추가 정보