Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2를 포함하는 SH2 영역은 인간에서 INPPL1 유전자 에 의해 암호화되는 효소 다.[5] [6]
INPPL1은 inositol polyphosphate-5 phosphatase와 유사한 1을 인코딩하는데, 인산염 영역 외에 SH2(src-homology domain 2) 모티브가 들어 있는 단백질이다.[6]
상호작용 INPPL1은 다음과 상호 작용하는 것으로 나타났다.
참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000165458 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000032737 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Hejna JA, Saito H, Merkens LS, Tittle TV, Jakobs PM, Whitney MA, Grompe M, Friedberg AS, Moses RE (February 1996). "Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases". Genomics . 29 (1): 285–7. doi :10.1006/geno.1995.1247 . PMID 8530088 . ^ a b "Entrez Gene: INPPL1 inositol polyphosphate phosphatase-like 1" .^ Prasad N, Topping RS, Decker SJ (February 2001). "SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading" . Mol. Cell. Biol . 21 (4): 1416–28. doi :10.1128/MCB.21.4.1416-1428.2001 . PMC 99593 PMID 11158326 . ^ Dyson JM, O'Malley CJ, Becanovic J, Munday AD, Berndt MC, Coghill ID, Nandurkar HH, Ooms LM, Mitchell CA (December 2001). "The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin" . J. Cell Biol . 155 (6): 1065–79. doi :10.1083/jcb.200104005 . PMC 2150887 PMID 11739414 . ^ Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B (April 1999). "A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells". Blood . 93 (8): 2707–20. doi :10.1182/blood.V93.8.2707 . PMID 10194451 . ^ Pesesse X, Dewaste V, De Smedt F, Laffargue M, Giuriato S, Moreau C, Payrastre B, Erneux C (July 2001). "The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells" . J. Biol. Chem . 276 (30): 28348–55. doi :10.1074/jbc.M103537200 PMID 11349134 . ^ Habib T, Hejna JA, Moses RE, Decker SJ (July 1998). "Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein" . J. Biol. Chem . 273 (29): 18605–9. doi :10.1074/jbc.273.29.18605 PMID 9660833 . ^ Vandenbroere I, Paternotte N, Dumont JE, Erneux C, Pirson I (January 2003). "The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2". Biochem. Biophys. Res. Commun . 300 (2): 494–500. doi :10.1016/s0006-291x(02)02894-2 . PMID 12504111 .
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