E3 유비퀴틴 단백질 리가아제 1을 포함한 HEC, C2, WW 도메인은 HECW1 [5]유전자에 의해 인체 내에서 코드되는 단백질이다.인간의 경우 1606개의 아미노산(179.5kDa)과 5.18의 [6]등전점을 가지고 있다.
레퍼런스
추가 정보
- Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A (March 2004). "NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1". The Journal of Biological Chemistry. 279 (12): 11327–35. doi:10.1074/jbc.M312389200. PMID 14684739.
- Chansard M, Wang J, Tran HC, Neumayer G, Shim SY, Park YU, Belzil C, Le HT, Park SK, Nguyen MD (January 2011). "The cytoskeletal protein Ndel1 regulates dynamin 2 GTPase activity". PLOS ONE. 6 (1): e14583. Bibcode:2011PLoSO...614583C. doi:10.1371/journal.pone.0014583. PMC 3026782. PMID 21283621.
- Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC (January 2014). "Genome-wide association study of the rate of cognitive decline in Alzheimer's disease". Alzheimer's & Dementia. 10 (1): 45–52. doi:10.1016/j.jalz.2013.01.008. PMC 3760995. PMID 23535033.
- Li Y, Ozaki T, Kikuchi H, Yamamoto H, Ohira M, Nakagawara A (June 2008). "A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner". Oncogene. 27 (26): 3700–9. doi:10.1038/sj.onc.1211032. PMID 18223681.
- Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". The Journal of Biological Chemistry. 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092.
- Zhang L, Haraguchi S, Koda T, Hashimoto K, Nakagawara A (2011). "Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice". Journal of Biomedicine & Biotechnology. 2011: 1–7. doi:10.1155/2011/831092. PMC 2952905. PMID 20976258.
- Cui Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L (May 2011). "SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1". The EMBO Journal. 30 (13): 2675–89. doi:10.1038/emboj.2011.155. PMC 3155294. PMID 21572392.
- Shinada K, Tsukiyama T, Sho T, Okumura F, Asaka M, Hatakeyama S (January 2011). "RNF43 interacts with NEDL1 and regulates p53-mediated transcription". Biochemical and Biophysical Research Communications. 404 (1): 143–7. doi:10.1016/j.bbrc.2010.11.082. hdl:2115/44929. PMID 21108931.
- Levine DM, Ek WE, Zhang R, Liu X, Onstad L, Sather C, Lao-Sirieix P, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Murray LJ, Reid BJ, Chow WH, Risch HA, Nyrén O, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Chanock SJ, Harrington P, Caldas I, Debiram-Beecham I, Caldas C, Hayward NK, Pharoah PD, Fitzgerald RC, Macgregor S, Whiteman DC, Vaughan TL (December 2013). "A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus". Nature Genetics. 45 (12): 1487–93. doi:10.1038/ng.2796. PMC 3840115. PMID 24121790.
