GNRH2

GNRH2
식별자
에일리어스	GNRH2, GnRH-II, LH-RHII, 고나도트로핀 방출호르몬
외부 ID	OMIM: 602352 HomoloGene: 128642 GenCard: GNRH2
유전자 위치(인간)
크르.	20번 염색체(인간)
끝.	3,045,128 bp
RNA발현패턴
	상단 표시 위치:
	간우엽; ; 소뇌 반구; ; 위점막; ; 우관상 동맥; ; 뇌하수체; ; 자궁내막간질세포; ; 뇌하수체 전엽; ; 자궁경관; ; 슬와 동맥; ; 골격근 조직;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	호르몬 활성; 고나도트로핀호르몬활성화호르몬활성; 고나도트로핀분해호르몬수용체결합;
셀룰러 컴포넌트	세포외 영역; 세포외 공간;
생물학적 과정	다세포 생물 발달; 신호 변환; 신호수용체활성조절; G단백질결합수용체신호경로; 복제품;
	출처:아미고 / QuickGO
맞춤법
	2797
	없음
	ENSG00000125787
	없음
	O43555
	없음
	NM_001310220; NM_001501; NM_178331; NM_178332
	없음
	NP_001297149; NP_001492; NP_847901; NP_847902
	없음
	위키데이터
인간 보기/편집

프로고나돌리베린-2는 인간의 GNRH2 ^[3]^[4]^[5]유전자에 의해 암호화되는 단백질이다.

이 유전자에 의해 코드된 단백질은 분해되어 분비된 10aa 펩타이드 호르몬을 형성하는 사전단백질이다.QHWSHGWYPG분비되는 데카펩타이드는 황체화 호르몬과 모낭자극 호르몬의 분비를 자극하여 여성의 번식을 조절합니다.^[6]이 ^[5]유전자에 대해 독특한 프로프로틴을 코드하지만 동일한 펩타이드 호르몬을 코드하는 세 가지 전사 변형이 발견되었다.펩타이드는 고나도트로핀 방출 호르몬군에 속한다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000125787 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ White RB, Eisen JA, Kasten TL, Fernald RD (Feb 1998). "Second gene for gonadotropin-releasing hormone in humans". Proc Natl Acad Sci U S A. 95 (1): 305–9. Bibcode:1998PNAS...95..305W. doi:10.1073/pnas.95.1.305. PMC 18209. PMID 9419371.
^ Chen A, Ganor Y, Rahimipour S, Ben-Aroya N, Koch Y, Levite M (Nov 2002). "The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs". Nat Med. 8 (12): 1421–6. doi:10.1038/nm801. PMID 12447356.
^ ^a ^b "Entrez Gene: GNRH2 gonadotropin-releasing hormone 2".
^ "GNRH2 - Progonadoliberin-2 precursor - Homo sapiens (Human) - GNRH2 gene & protein". uniprot. Retrieved 19 January 2019.

추가 정보

Neill JD (2002). "GnRH and GnRH receptor genes in the human genome". Endocrinology. 143 (3): 737–43. doi:10.1210/endo.143.3.8705. PMID 11861490.
Leung PC, Cheng CK, Zhu XM (2004). "Multi-factorial role of GnRH-I and GnRH-II in the human ovary". Mol. Cell. Endocrinol. 202 (1–2): 145–53. doi:10.1016/S0303-7207(03)00076-5. PMID 12770744. S2CID 24945436.
Limonta P, Moretti RM, Marelli MM, Motta M (2004). "The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans". Frontiers in Neuroendocrinology. 24 (4): 279–95. doi:10.1016/j.yfrne.2003.10.003. PMID 14726258. S2CID 33327806.
Bloch B, Gaillard RC, Culler MD, Negro-Vilar A (1992). "Immunohistochemical detection of proluteinizing hormone-releasing hormone peptides in neurons in the human hypothalamus". J. Clin. Endocrinol. Metab. 74 (1): 135–8. doi:10.1210/jcem.74.1.1727812. PMID 1727812.
Chen A, Laskar-Levy O, Ben-Aroya N, Koch Y (2001). "Transcriptional regulation of the human GnRH II gene is mediated by a putative cAMP response element". Endocrinology. 142 (8): 3483–92. doi:10.1210/endo.142.8.8302. PMID 11459794.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Gründker C, Günthert AR, Millar RP, Emons G (2002). "Expression of gonadotropin-releasing hormone II (GnRH-II) receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation". J. Clin. Endocrinol. Metab. 87 (3): 1427–30. doi:10.1210/jcem.87.3.8437. PMID 11889221.
Chen A, Zi K, Laskar-Levy O, Koch Y (2002). "The transcription of the hGnRH-I and hGnRH-II genes in human neuronal cells is differentially regulated by estrogen". J. Mol. Neurosci. 18 (1–2): 67–76. doi:10.1385/JMN:18:1-2:65. PMID 11931351. S2CID 289773.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cheng CK, Hoo RL, Chow BK, Leung PC (2004). "Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene". Mol. Endocrinol. 17 (7): 1175–91. doi:10.1210/me.2002-0418. PMID 12663744.
Islami D, Bischof P, Chardonnens D (2004). "Possible interactions between leptin, gonadotrophin-releasing hormone (GnRH-I and II) and human chorionic gonadotrophin (hCG)". Eur. J. Obstet. Gynecol. Reprod. Biol. 110 (2): 169–75. doi:10.1016/S0301-2115(03)00185-4. PMID 12969578.
Chou CS, Beristain AG, MacCalman CD, Leung PC (2004). "Cellular localization of gonadotropin-releasing hormone (GnRH) I and GnRH II in first-trimester human placenta and decidua". J. Clin. Endocrinol. Metab. 89 (3): 1459–66. doi:10.1210/jc.2003-031636. PMID 15001648.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
An BS, Choi JH, Choi KC, Leung PC (2005). "Differential role of progesterone receptor isoforms in the transcriptional regulation of human gonadotropin-releasing hormone I (GnRH I) receptor, GnRH I, and GnRH II". J. Clin. Endocrinol. Metab. 90 (2): 1106–13. doi:10.1210/jc.2004-0318. PMID 15562029.
Tanriverdi F, Gonzalez-Martinez D, Silveira LF, et al. (2005). "Expression of gonadotropin-releasing hormone type-I (GnRH-I) and type-II (GnRH-II) in human peripheral blood mononuclear cells (PMBCs) and regulation of B-lymphoblastoid cell proliferation by GnRH-I and GnRH-II". Exp. Clin. Endocrinol. Diabetes. 112 (10): 587–94. doi:10.1055/s-2004-830404. PMID 15578334.

인간 염색체 20번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000125787 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9419371-3] White RB, Eisen JA, Kasten TL, Fernald RD (Feb 1998). "Second gene for gonadotropin-releasing hormone in humans". Proc Natl Acad Sci U S A. 95 (1): 305–9. Bibcode:1998PNAS...95..305W. doi:10.1073/pnas.95.1.305. PMC 18209. PMID 9419371.

[pmid12447356-4] Chen A, Ganor Y, Rahimipour S, Ben-Aroya N, Koch Y, Levite M (Nov 2002). "The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs". Nat Med. 8 (12): 1421–6. doi:10.1038/nm801. PMID 12447356.

[entrez-5] "Entrez Gene: GNRH2 gonadotropin-releasing hormone 2".

[uniprot-6] "GNRH2 - Progonadoliberin-2 precursor - Homo sapiens (Human) - GNRH2 gene & protein". uniprot. Retrieved 19 January 2019.

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GNRH2

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