FYB

FYB1
사용 가능한 구조물
PDB	직교 검색: PDBe RCSB
PDB ID 코드 목록
	1RI9, 2GTJ, 2GTO
식별자
별칭	FYB1, 적응, PRO0823, 슬랩-130, 슬랩130, FYB, FIN 결합 단백질, THC3, FIN 결합 단백질 1
외부 ID	OMIM: 602731 MGI: 1346327 호몰로진: 22664 GeneCard: FYB1
유전자 위치(인간)
쳇.	5번 염색체(인간)
끝	39,274,528 bp
유전자 위치(마우스)
쳇.	15번 염색체(쥐)
끝	6,692,794 bp
RNA 표현 패턴
	표현된 상단
	핏덩어리; ; 골수; ; 맹장; ; 림프절; ; 비장의; ; 폐골.; ; 흉선; ; 폐를 끼치다; ; 후두엽; ; 내성 늑막;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	신호 수용체 결합; GO:0001948 단백질 결합; 지질 결합; GO:0032403 단백질 함유 복합 결합;
셀룰러 컴포넌트	세포질; 시토솔; 핵의; 시토스켈레톤으로 행동하다.; 플라즈마 막; 세포 접합;
생물학적 과정	단백질 인산화; GO:0007243 세포내 신호 전달; 혈장 막에 대한 단백질 국산화; T세포수용체신호경로; 면역 반응; 신호 전달; NLS-베어링 단백질 핵으로 수입; 생물학적 과정; 통합 매개 신호 경로;
	출처:아미고 / 퀵고
직교체
	2533
	23880
	ENSG00000082074
	ENSMUSG00000022148
	O15117
	O35601
	NM_001243093; NM_001465; NM_199335; NM_001349333; NM_018594
	NM_001278269; NM_011815
	NP_001230022; NP_001456; NP_955367; NP_001336262; NP_061064
	NP_001265198; NP_035945
	위키다타
인간 보기/편집	마우스 보기/편집

FYB라고도 알려진 FYB 결합 단백질(FYB-120/130), ADAPT(접착 및 분해 촉진 어댑터 단백질), SLP-130(SLP-76 관련 인산단백질 130kDa)은 인간에서 FYB 유전자에 의해 암호화된 단백질이다.^[5]

상호작용

FYB는 다음과 상호 작용하는 것으로 나타났다.

FIN,^[6]^[7]
SLP-76(림포세포 세포질 단백질 2) ^[8]및
SKAP1.^[7]^[9]

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG000082074 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000022148 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FYB FYN binding protein (FYB-120/130)".
^ da Silva AJ, Janssen O, Rudd CE (Dec 1993). "T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)". J. Exp. Med. 178 (6): 2107–13. doi:10.1084/jem.178.6.2107. PMC 2191307. PMID 7504057.
^ ^a ^b Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA (Oct 1998). "Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130". J. Biol. Chem. 273 (40): 25789–95. doi:10.1074/jbc.273.40.25789. PMID 9748251.
^ Musci MA, Hendricks-Taylor LR, Motto DG, Paskind M, Kamens J, Turck CW, Koretzky GA (1997). "Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases". J. Biol. Chem. 272 (18): 11674–7. doi:10.1074/jbc.272.18.11674. PMID 9115214.
^ Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE (Jul 1998). "FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8779–84. Bibcode:1998PNAS...95.8779L. doi:10.1073/pnas.95.15.8779. PMC 21153. PMID 9671755.

추가 읽기

da Silva AJ, Janssen O, Rudd CE (1993). "T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)". J. Exp. Med. 178 (6): 2107–13. doi:10.1084/jem.178.6.2107. PMC 2191307. PMID 7504057.
Musci MA, Hendricks-Taylor LR, Motto DG, Paskind M, Kamens J, Turck CW, Koretzky GA (1997). "Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases". J. Biol. Chem. 272 (18): 11674–7. doi:10.1074/jbc.272.18.11674. PMID 9115214.
da Silva AJ, Li Z, de Vera C, Canto E, Findell P, Rudd CE (1997). "Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7493–8. Bibcode:1997PNAS...94.7493D. doi:10.1073/pnas.94.14.7493. PMC 23849. PMID 9207119.
Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE (1998). "FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8779–84. Bibcode:1998PNAS...95.8779L. doi:10.1073/pnas.95.15.8779. PMC 21153. PMID 9671755.
Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA (1998). "Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130". J. Biol. Chem. 273 (40): 25789–95. doi:10.1074/jbc.273.40.25789. PMID 9748251.
Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55". FEBS Lett. 435 (1): 55–60. doi:10.1016/S0014-5793(98)01040-0. PMID 9755858. S2CID 37288744.
Veale M, Raab M, Li Z, da Silva AJ, Kraeft SK, Weremowicz S, Morton CC, Rudd CE (1999). "Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production". J. Biol. Chem. 274 (40): 28427–35. doi:10.1074/jbc.274.40.28427. PMID 10497204.
Hamid N, Gustavsson A, Andersson K, McGee K, Persson C, Rudd CE, Fällman M (1999). "YopH dephosphorylates Cas and Fyn-binding protein in macrophages". Microbial Pathogenesis. 27 (4): 231–42. doi:10.1006/mpat.1999.0301. PMID 10502464.
Geng L, Raab M, Rudd CE (1999). "Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651". J. Immunol. 163 (11): 5753–7. PMID 10570256.
Krause M, Sechi AS, Konradt M, Monner D, Gertler FB, Wehland J (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton". J. Cell Biol. 149 (1): 181–94. doi:10.1083/jcb.149.1.181. PMC 2175102. PMID 10747096.
Kang H, Freund C, Duke-Cohan JS, Musacchio A, Wagner G, Rudd CE (2000). "SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55". EMBO J. 19 (12): 2889–99. doi:10.1093/emboj/19.12.2889. PMC 203341. PMID 10856234.
Asazuma N, Wilde JI, Berlanga O, Leduc M, Leo A, Schweighoffer E, Tybulewicz V, Bon C, Liu SK, McGlade CJ, Schraven B, Watson SP (2000). "Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin". J. Biol. Chem. 275 (43): 33427–34. doi:10.1074/jbc.M001439200. PMID 10942756.
Li C, Iosef C, Jia CY, Han VK, Li SS (2003). "Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors". J. Biol. Chem. 278 (6): 3852–9. doi:10.1074/jbc.M206649200. PMID 12458214.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Heuer K, Arbuzova A, Strauss H, Kofler M, Freund C (2005). "The helically extended SH3 domain of the T cell adaptor protein ADAP is a novel lipid interaction domain". J. Mol. Biol. 348 (4): 1025–35. doi:10.1016/j.jmb.2005.02.069. PMID 15843031.
Huang Y, Norton DD, Precht P, Martindale JL, Burkhardt JK, Wange RL (2005). "Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells". J. Biol. Chem. 280 (25): 23576–83. doi:10.1074/jbc.M413201200. PMID 15849195.
Koga S, Yogo K, Yoshikawa K, Samori H, Goto M, Uchida T, Ishida N, Takeya T (2005). "Physical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitro". J. Biol. Chem. 280 (36): 31564–71. doi:10.1074/jbc.M502703200. PMID 16020549.
Duke-Cohan JS, Kang H, Liu H, Rudd CE (2006). "Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein". J. Biol. Chem. 281 (19): 13743–50. doi:10.1074/jbc.M508774200. PMID 16461356.

인간 5번 염색체의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG000082074 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000022148 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FYB FYN binding protein (FYB-120/130)".

[pmid7504057-6] Silva AJ, Janssen O, Rudd CE (Dec 1993). "T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)". J. Exp. Med. 178 (6): 2107–13. doi:10.1084/jem.178.6.2107. PMC 2191307. PMID 7504057.

[pmid9748251-7] Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA (Oct 1998). "Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130". J. Biol. Chem. 273 (40): 25789–95. doi:10.1074/jbc.273.40.25789. PMID 9748251.

[pmid9115214-8] Musci MA, Hendricks-Taylor LR, Motto DG, Paskind M, Kamens J, Turck CW, Koretzky GA (1997). "Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases". J. Biol. Chem. 272 (18): 11674–7. doi:10.1074/jbc.272.18.11674. PMID 9115214.

[pmid9671755-9] Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE (Jul 1998). "FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8779–84. Bibcode:1998PNAS...95.8779L. doi:10.1073/pnas.95.15.8779. PMC 21153. PMID 9671755.

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FYB

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