DNASE1L3

DNASE1L3
식별자
에일리어스	DNASE1L3, DHP2, DNAS1L3, LSD, SLEB16, 디옥시리보핵산가수분해효소 I like 3, 디옥시리보핵산가수분해효소 1 like 3
외부 ID	OMIM : 602244 MGI : 1314633 HomoloGene : 3630 GenCard : DNAESE1L3
유전자 위치(인간)
크르.	3번 염색체(인간)
끝.	58,214,697 bp
유전자 위치(마우스)
크르.	14번 염색체(쥐)
끝.	14,505,240 bp
RNA발현패턴
	상단 표시 위치:
	치주 섬유; ; 비장; ; 결석골; ; 간; ; 간우엽; ; 우부신; ; 부록; ; 직장; ; 안검결막; ; 활액관절;
	상단 표시 위치:
	간좌엽; ; 비장; ; 태반; ; 입술; ; 흉선; ; 이차 난모세포; ; 식도; ; jejunum; ; 피하 지방 조직; ; 십이지장;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; 칼슘 이온 결합; 핵산가수분해효소활성; 엔도핵산가수분해효소활성; 엔도데옥시리보핵산가수분해효소활성; 가수분해효소활성; 디옥시리보핵산가수분해효소활성; 디옥시리보핵산가수분해효소I활성;
셀룰러 컴포넌트	세포외 영역; 소포체; 핵;
생물학적 과정	DNA대사과정; DNA이화과정; 세포 발달에 관여하는 프로그램된 세포사; 아포토시스 과정; 프로그램 세포사; 아포토시스 DNA 단편화; DNA 이화 과정, 핵내 분해; Neutrophil 활성화 면역 반응에 참여하고 있습니다.; 급성 염증 반응의 규칙.; 호중성 매개된 세포 독성의 규정이다.;
	출처:아미고 / QuickGO
맞춤법
	1776
	13421
	ENSG00000163687
	ENSMUSG00000025279
	Q13609
	O55070
	NM_004944; NM_001256560
	NM_007870
	NP_001243489; NP_004935
	NP_031896
	위키데이터
인간 보기/편집	마우스 표시/편집

디옥시리보핵산가수분해효소 감마는 인간에서 DNAES1L3 ^[5]^[6]^[7]^[8]유전자에 의해 암호화되는 효소이다.

이 유전자는 DNase 계열의 일원을 암호화한다.단백질은 DNA를 가수분해하고, 액틴에 의해 억제되지 않으며, 아포토시스 동안 DNA의 분해를 매개한다.이 유전자의 대체 전사 스플라이스 변형이 관찰되었지만 완전히 ^[8]특징지어지지는 않았다.

늘 대립 유전자에 대한 호모 접합성은 전신성 홍반성 낭창을 일으킨다.^[9]DNASE1L3의 기능성 대립 유전자의 상실은 류마티스 ^[10]관절염과 관련이 있다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000163687 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000025279 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (June 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.
^ Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, Baker KP (July 1998). "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages". Gene. 215 (2): 291–301. doi:10.1016/S0378-1119(98)00281-9. PMID 9714828.
^ Shiokawa D, Hirai M, Tanuma S (March 1998). "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein". Apoptosis. 3 (2): 89–95. doi:10.1023/A:1009692807692. PMID 14646506. S2CID 2071259.
^ ^a ^b "Entrez Gene: DNASE1L3 deoxyribonuclease I-like 3".
^ Al-Mayouf SM, Sunker A, Abdwani R, Abrawi SA, Almurshedi F, Alhashmi N, et al. (October 2011). "Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus". Nature Genetics. 43 (12): 1186–8. doi:10.1038/ng.975. PMID 22019780. S2CID 205358301.
^ Westra HJ, Martínez-Bonet M, Onengut-Gumuscu S, Lee A, Luo Y, Teslovich N, et al. (October 2018). "Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes". Nature Genetics. 50 (10): 1366–1374. doi:10.1038/s41588-018-0216-7. PMC 6364548. PMID 30224649.

추가 정보

Tanuma S, Shiokawa D (September 1994). "Multiple forms of nuclear deoxyribonuclease in rat thymocytes". Biochemical and Biophysical Research Communications. 203 (2): 789–97. doi:10.1006/bbrc.1994.2252. PMID 8093058.
Zeng Z, Parmelee D, Hyaw H, Coleman TA, Su K, Zhang J, et al. (February 1997). "Cloning and characterization of a novel human DNase". Biochemical and Biophysical Research Communications. 231 (2): 499–504. doi:10.1006/bbrc.1996.5923. PMID 9070308.
Shiokawa D, Tanuma S (January 2001). "Characterization of human DNase I family endonucleases and activation of DNase gamma during apoptosis". Biochemistry. 40 (1): 143–52. doi:10.1021/bi001041a. PMID 11141064.
Wilber A, Lu M, Schneider MC (July 2002). "Deoxyribonuclease I-like III is an inducible macrophage barrier to liposomal transfection". Molecular Therapy. 6 (1): 35–42. doi:10.1006/mthe.2002.0625. PMID 12095301.
Boulares AH, Zoltoski AJ, Sherif ZA, Yakovlev AG, Smulson ME (August 2002). "The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells". Cancer Research. 62 (15): 4439–44. PMID 12154052.
Shiokawa D, Shika Y, Tanuma S (December 2003). "Identification of two functional nuclear localization signals in DNase gamma and their roles in its apoptotic DNase activity". The Biochemical Journal. 376 (Pt 2): 377–81. doi:10.1042/BJ20030820. PMC 1223774. PMID 12943533.
Boulares AH, Ren T (January 2004). "Mechanism of acetaminophen-induced apoptosis in cultured cells: roles of caspase-3, DNA fragmentation factor, and the Ca2+ and Mg2+ endonuclease DNAS1L3". Basic & Clinical Pharmacology & Toxicology. 94 (1): 19–29. doi:10.1111/j.1742-7843.2004.pto_940105.x. PMID 14725611.
Okamoto M, Okamoto N, Yashiro H, Shiokawa D, Sunaga S, Yoshimori A, et al. (February 2005). "Involvement of DNase gamma in the resected double-strand DNA breaks in immunoglobulin genes". Biochemical and Biophysical Research Communications. 327 (1): 76–83. doi:10.1016/j.bbrc.2004.11.142. PMID 15629432.
Boulares H, Zoltoski A, Kandan S, Akbulut T, Yakovlev A, Oumouna M (March 2006). "Correlation between decreased sensitivity of the Daudi lymphoma cells to VP-16-induced apoptosis and deficiency in DNAS1L3 expression". Biochemical and Biophysical Research Communications. 341 (2): 653–62. doi:10.1016/j.bbrc.2006.01.014. PMID 16427601.

인간 염색체 3번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000163687 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000025279 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9205125-5] Rodriguez AM, Rodin D, Nomura H, Morton CC, Weremowicz S, Schneider MC (June 1997). "Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I". Genomics. 42 (3): 507–13. doi:10.1006/geno.1997.4748. PMID 9205125.

[pmid9714828-6] Baron WF, Pan CQ, Spencer SA, Ryan AM, Lazarus RA, Baker KP (July 1998). "Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages". Gene. 215 (2): 291–301. doi:10.1016/S0378-1119(98)00281-9. PMID 9714828.

[pmid14646506-7] Shiokawa D, Hirai M, Tanuma S (March 1998). "cDNA cloning of human DNase gamma: chromosomal localization of its gene and enzymatic properties of recombinant protein". Apoptosis. 3 (2): 89–95. doi:10.1023/A:1009692807692. PMID 14646506. S2CID 2071259.

[entrez-8] "Entrez Gene: DNASE1L3 deoxyribonuclease I-like 3".

[Al-MayoufSunker2011-9] Al-Mayouf SM, Sunker A, Abdwani R, Abrawi SA, Almurshedi F, Alhashmi N, et al. (October 2011). "Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus". Nature Genetics. 43 (12): 1186–8. doi:10.1038/ng.975. PMID 22019780. S2CID 205358301.

[10] Westra HJ, Martínez-Bonet M, Onengut-Gumuscu S, Lee A, Luo Y, Teslovich N, et al. (October 2018). "Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes". Nature Genetics. 50 (10): 1366–1374. doi:10.1038/s41588-018-0216-7. PMC 6364548. PMID 30224649.

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DNASE1L3

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