DGKA
DGKA| DGKA | |||||||||||||||||||||||||
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| 식별자 | |||||||||||||||||||||||||
| 에일리어스 | DGKA, DAGK, DAGK1, DGK-alpha, 디아실글리세롤인산화효소α | ||||||||||||||||||||||||
| 외부 ID | OMIM : 125855 MGI : 102952 HomoloGene : 1028 GenCard : DGKA | ||||||||||||||||||||||||
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| 맞춤법 | |||||||||||||||||||||||||
| 종. | 인간 | 마우스 | |||||||||||||||||||||||
| 엔트레즈 | |||||||||||||||||||||||||
| 앙상블 | |||||||||||||||||||||||||
| 유니프로트 | |||||||||||||||||||||||||
| RefSeq(mRNA) |
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| RefSeq(단백질) |
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| 장소(UCSC) | Chr 12: 55.93 ~55.95 Mb | Chr 10: 128.56 ~128.58 Mb | |||||||||||||||||||||||
| PubMed 검색 | [3] | [4] | |||||||||||||||||||||||
| 위키데이터 | |||||||||||||||||||||||||
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디아실글리세롤인산화효소 알파는 인간에서 DGKA 유전자에 [5][6][7]의해 암호화되는 효소이다.
이 유전자에 의해 암호화된 단백질은 진핵생물 디아실글리세롤 키나아제 계열에 속합니다.그것은 세포 내 신호 전달 경로에서 두 번째 메신저 디아실글리세롤에 대해 단백질 키나제 C와 경쟁하는 조절제 역할을 한다.또한 포스파티딜이노시톨의 재합성 및 디아실글리세롤을 포스파티드산으로 인산화하는 데 중요한 역할을 한다.대체 스플라이싱은 이 궤적에서 발생하며 동일한 단백질을 코드하는 4개의 전사 변종이 확인되었다.[7]
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000065357 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000025357 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hart TC, Champagne C, Zhou J, Van Dyke TE (Jun 1994). "Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12". Mamm Genome. 5 (2): 123–4. doi:10.1007/BF00292343. PMID 8180475. S2CID 305119.
- ^ Hart TC, Zhou J, Champagne C, Van Dyke TE, Rao PN, Pettenati MJ (Dec 1994). "Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis". Genomics. 22 (1): 246–7. doi:10.1006/geno.1994.1376. PMID 7959783.
- ^ a b "Entrez Gene: DGKA diacylglycerol kinase, alpha 80kDa".
추가 정보
[1]*Topham MK, Prescott SM (1999). "Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions". J. Biol. Chem. 274 (17): 11447–50. doi:10.1074/jbc.274.17.11447. PMID 10206945.
- Schaap D, de Widt J, van der Wal J, et al. (1991). "Purification, cDNA-cloning and expression of human diacylglycerol kinase". FEBS Lett. 275 (1–2): 151–8. doi:10.1016/0014-5793(90)81461-V. PMID 2175712. S2CID 45452518.
- Flores I, Casaseca T, Martinez-A C, et al. (1996). "Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation". J. Biol. Chem. 271 (17): 10334–40. doi:10.1074/jbc.271.17.10334. PMID 8626603.
- Jones DR, Pettitt TR, Sanjuán MA, et al. (1999). "Interleukin-2 causes an increase in saturated/monounsaturated phosphatidic acid derived from 1,2-diacylglycerol and 1-O-alkyl-2-acylglycerol". J. Biol. Chem. 274 (24): 16846–52. doi:10.1074/jbc.274.24.16846. PMID 10358029.
- Sanjuán MA, Jones DR, Izquierdo M, Mérida I (2001). "Role of Diacylglycerol Kinase α in the Attenuation of Receptor Signaling". J. Cell Biol. 153 (1): 207–20. doi:10.1083/jcb.153.1.207. PMC 2185527. PMID 11285286.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sanjuán MA, Pradet-Balade B, Jones DR, et al. (2003). "T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation". J. Immunol. 170 (6): 2877–83. doi:10.4049/jimmunol.170.6.2877. PMID 12626538.
- Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gronert K, Kantarci A, Levy BD, et al. (2004). "A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage". J. Immunol. 172 (3): 1856–61. doi:10.4049/jimmunol.172.3.1856. PMC 4318492. PMID 14734770.
- Verrier E, Wang L, Wadham C, et al. (2004). "PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase". Circ. Res. 94 (11): 1515–22. doi:10.1161/01.RES.0000130527.92537.06. PMID 15117825.
- Baldanzi G, Mitola S, Cutrupi S, et al. (2004). "Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro". Oncogene. 23 (28): 4828–38. doi:10.1038/sj.onc.1207633. PMID 15122338.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Alonso R, Rodríguez MC, Pindado J, et al. (2005). "Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes". J. Biol. Chem. 280 (31): 28439–50. doi:10.1074/jbc.M501112200. PMID 15870081.
- Bacchiocchi R, Baldanzi G, Carbonari D, et al. (2005). "Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase". Blood. 106 (6): 2175–82. doi:10.1182/blood-2005-01-0316. PMID 15928040.
- Yanagisawa K, Yasuda S, Kai M, et al. (2007). "Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation". Biochim. Biophys. Acta. 1771 (4): 462–74. doi:10.1016/j.bbalip.2006.12.008. PMID 17276726.
외부 링크
PDB 갤러리 | |
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- ^ Kovalenko, A; Sanin, A; Kosmas, K; Zhang, L; Wang, J; Giannikou, K; Probst, CK; Hougard, TR; Rue, RW; Krymskaya, VP; Asara, JM; Lam, HC; Kwiatkowski, DJ; Henske, EP; Filippakis, H (2021). "Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex". Cancer Research. 81 (8): 2086. doi:10.1158/0008-5472.CAN-20-2218. PMID 33593821.
