DCTN2

DCTN2
식별자
에일리어스	DCTN2, DCTN50, DYNAMITIN, HEL-S-77, RBP50, 다이낙틴 서브유닛2
외부 ID	OMIM : 607376 MGI : 107733 HomoloGene : 4667 GenCard : DCTN2
유전자 위치(마우스)
크르.	10번 염색체(쥐)
끝.	127,819 bp
RNA발현패턴
	없음
	; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	스펙트린 결합; GO:0001948 단백질 결합; 세포골격운동활성; 동일단백질결합; 단백질인산화효소결합; 숙주세포표면수용체결합;
셀룰러 컴포넌트	베시클; 중심체; 막; 다이낙틴 착화체; 성장 원뿔; 미소관 조직 센터; 다이네인 착화체; 미소관; 세포외 엑소좀; 세포골격; 키네토코어; 세포질; 세포;
생물학적 과정	항원처리 및 MHC 클래스 II를 통한 외인성 펩타이드 항원 제시; GO:0043148 유사분열 스핀들 구성; 골지 소포 매개 수송에 대한 소포체; 유사분열세포주기의 G2/M 전이; 멜라노솜수송; 미소관 기반 과정; 중심체에 대한 단백질 국재; 세포군 증식; 섬모 기저막 도킹; 유사분열세포주기의 G2/M 전이조절; GO:0007067 유사분열세포 사이클;
	출처:아미고 / QuickGO
맞춤법
	10540
	69654
	ENSG00000175203
	ENSMUSG000025410
	문제 13561
	Q99KJ8
	NM_001261412; NM_001261413; NM_006400
	NM_001190453; NM_001190454; NM_027151
NP_001248341; NP_001248342; NP_006391; NP_001334994; NP_001334995;
	NP_001334996; NP_001334997
	NP_001177382; NP_001177383; NP_081427
	위키데이터
인간 보기/편집	마우스 표시/편집

Dynactin subunit 2는 DCTN2^[4]^[5] 유전자에 의해 인간에게 암호화되는 단백질이다.

기능.

이 유전자는 23개의 소단위(22~^[6]150kD 크기의 11개의 개별 단백질)로 구성된 고분자 복합체인 다이낙틴의 50kD 서브단위를 암호화한다.서브유닛은 일반적으로 p50 또는 ^[4]dynamitin이라고 불립니다.다이낙틴은 미소관과 세포질 다이네인에 모두 결합한다.그것은 ER-Golgi 수송, 리소좀과 엔도솜의 구심 이동, 방추 형성, 염색체 이동, 핵 위치 결정, 축삭 형성을 포함한 다양한 세포 기능에 관여합니다.이 서브유닛은 다이낙틴 분자당 4개의 복사본으로 존재한다.이것은 dynactin 어깨 ^[6]도메인을 형성하기 위해 p150-glued(DCTN1)의 두 복사본과 p24(DCTN3)의 두 복사본에 결합하는 세 개의 짧은 알파 나선 코일 도메인을 포함합니다.

상호 작용

DCTN2는 MARCKSL1과 ^[7]대화하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000025410 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Echeverri CJ, Paschal BM, Vaughan KT, Vallee RB (February 1996). "Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis". The Journal of Cell Biology. 132 (4): 617–33. doi:10.1083/jcb.132.4.617. PMC 2199864. PMID 8647893.
^ "Entrez Gene: DCTN2 dynactin 2 (p50)".
^ ^a ^b Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP (March 2015). "The structure of the dynactin complex and its interaction with dynein". Science. 347 (6229): 1441–1446. Bibcode:2015Sci...347.1441U. doi:10.1126/science.aaa4080. PMC 4413427. PMID 25814576.
^ Yue L, Lu S, Garces J, Jin T, Li J (August 2000). "Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading". The Journal of Biological Chemistry. 275 (31): 23948–56. doi:10.1074/jbc.M001845200. PMID 10827182.

추가 정보

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Starr DA, Williams BC, Hays TS, Goldberg ML (August 1998). "ZW10 helps recruit dynactin and dynein to the kinetochore". The Journal of Cell Biology. 142 (3): 763–74. doi:10.1083/jcb.142.3.763. PMC 2148168. PMID 9700164.
Berrueta L, Tirnauer JS, Schuyler SC, Pellman D, Bierer BE (April 1999). "The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain". Current Biology. 9 (8): 425–8. doi:10.1016/S0960-9822(99)80190-0. PMID 10226031. S2CID 14191776.
Eckley DM, Gill SR, Melkonian KA, Bingham JB, Goodson HV, Heuser JE, Schroer TA (October 1999). "Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end". The Journal of Cell Biology. 147 (2): 307–20. doi:10.1083/jcb.147.2.307. PMC 2174220. PMID 10525537.
Karki S, Tokito MK, Holzbaur EL (February 2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1". The Journal of Biological Chemistry. 275 (7): 4834–9. doi:10.1074/jbc.275.7.4834. PMID 10671518.
Merdes A, Heald R, Samejima K, Earnshaw WC, Cleveland DW (May 2000). "Formation of spindle poles by dynein/dynactin-dependent transport of NuMA". The Journal of Cell Biology. 149 (4): 851–62. doi:10.1083/jcb.149.4.851. PMC 2174573. PMID 10811826.
Yue L, Lu S, Garces J, Jin T, Li J (August 2000). "Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading". The Journal of Biological Chemistry. 275 (31): 23948–56. doi:10.1074/jbc.M001845200. PMID 10827182.
Vancoillie G, Lambert J, Haeghen YV, Westbroek W, Mulder A, Koerten HK, Mommaas AM, Van Oostveldt P, Naeyaert JM (December 2000). "Colocalization of dynactin subunits P150Glued and P50 with melanosomes in normal human melanocytes". Pigment Cell Research. 13 (6): 449–57. doi:10.1034/j.1600-0749.2000.130607.x. PMID 11153697.
Hoogenraad CC, Akhmanova A, Howell SA, Dortland BR, De Zeeuw CI, Willemsen R, Visser P, Grosveld F, Galjart N (August 2001). "Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes". The EMBO Journal. 20 (15): 4041–54. doi:10.1093/emboj/20.15.4041. PMC 149157. PMID 11483508.
Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (October 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177. S2CID 14031165.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Uetake Y, Terada Y, Matuliene J, Kuriyama R (May 2004). "Interaction of Cep135 with a p50 dynactin subunit in mammalian centrosomes". Cell Motility and the Cytoskeleton. 58 (1): 53–66. doi:10.1002/cm.10175. PMID 14983524.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (November 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Ficarro SB, Salomon AR, Brill LM, Mason DE, Stettler-Gill M, Brock A, Peters EC (2005). "Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites". Rapid Communications in Mass Spectrometry. 19 (1): 57–71. Bibcode:2005RCMS...19...57F. doi:10.1002/rcm.1746. PMID 15570572.

인간 염색체 12번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCm38Ensembl-1] GRCm38: 앙상블 릴리즈 89: ENSMUSG000025410 - 앙상블, 2017년 5월

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8647893-4] Echeverri CJ, Paschal BM, Vaughan KT, Vallee RB (February 1996). "Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis". The Journal of Cell Biology. 132 (4): 617–33. doi:10.1083/jcb.132.4.617. PMC 2199864. PMID 8647893.

[entrez-5] "Entrez Gene: DCTN2 dynactin 2 (p50)".

[:0-6] Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP (March 2015). "The structure of the dynactin complex and its interaction with dynein". Science. 347 (6229): 1441–1446. Bibcode:2015Sci...347.1441U. doi:10.1126/science.aaa4080. PMC 4413427. PMID 25814576.

[pmid10827182-7] Yue L, Lu S, Garces J, Jin T, Li J (August 2000). "Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading". The Journal of Biological Chemistry. 275 (31): 23948–56. doi:10.1074/jbc.M001845200. PMID 10827182.

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DCTN2

네임스페이스

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목차

기능.

상호 작용

레퍼런스

추가 정보