호모 사피엔스 종의 단백질 코드 유전자
브레펠딘A억제구아닌뉴클레오티드교환단백질2 는 ARFGEF2유전자 에 [5] [6] 단백질 이다.
기능. ADP-리보실화인자 (ARF)는 세포 내 소포트래픽에 중요한 역할을 한다.이 유전자에 의해 코드된 단백질은 결합 GDP의 GTP 치환을 가속화함으로써 ARF의 활성화에 관여하며 골지 수송 에 관여한다. 구아닌-뉴클레오티드 교환 활성 및 브레펠딘 A [6]
상호 작용 ARFGEF2는 ARFGEF1 ,[7] PRKAR1A [8] [8] PRKAR2A 와 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000124198 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000074582 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors" . The Journal of Biological Chemistry . 274 (18): 12308–15. doi :10.1074/jbc.274.18.12308 PMID 10212200 . ^ a b "Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)" .^ Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex" . Proceedings of the National Academy of Sciences of the United States of America . 97 (6): 2567–72. doi :10.1073/pnas.97.6.2567 PMC 15969 PMID 10716990 . ^ a b Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)" . Proceedings of the National Academy of Sciences of the United States of America . 100 (4): 1627–32. doi :10.1073/pnas.0337678100 PMC 149883 PMID 12571360 . 외부 링크 읽고 추가 Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex" . Proceedings of the National Academy of Sciences of the United States of America . 97 (6): 2567–72. doi :10.1073/pnas.97.6.2567 PMC 15969 PMID 10716990 . Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics . 69 (1): 113–9. doi :10.1006/geno.2000.6310 . PMID 11013081 . Pacheco-Rodriguez G, Moss J, Vaughan M (2002). "BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors". Methods in Enzymology . 345 : 397–404. doi :10.1016/S0076-6879(02)45032-X . ISBN 9780121822460 PMID 11665623 . Shinotsuka C, Yoshida Y, Kawamoto K, Takatsu H, Nakayama K (Mar 2002). "Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation" . The Journal of Biological Chemistry . 277 (11): 9468–73. doi :10.1074/jbc.M112427200 PMID 11777925 . Shinotsuka C, Waguri S, Wakasugi M, Uchiyama Y, Nakayama K (Jun 2002). "Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins". Biochemical and Biophysical Research Communications . 294 (2): 254–60. doi :10.1016/S0006-291X(02)00456-4 . PMID 12051703 . Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)" . Proceedings of the National Academy of Sciences of the United States of America . 100 (4): 1627–32. doi :10.1073/pnas.0337678100 PMC 149883 PMID 12571360 . Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA (Jan 2004). "Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex" . Nature Genetics . 36 (1): 69–76. doi :10.1038/ng1276 PMID 14647276 . Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway" . Genome Research . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130–5. doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Xu KF, Shen X, Li H, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2005). "Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70" . Proceedings of the National Academy of Sciences of the United States of America . 102 (8): 2784–9. doi :10.1073/pnas.0409871102 PMC 549493 PMID 15705715 . Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V (Jan 2006). "Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia". The Journal of Comparative Neurology . 494 (3): 476–84. doi :10.1002/cne.20806 . PMID 16320251 . S2CID 16527134 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Islam A, Shen X, Hiroi T, Moss J, Vaughan M, Levine SJ (Mar 2007). "The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles" . The Journal of Biological Chemistry . 282 (13): 9591–9. doi :10.1074/jbc.M607122200 PMID 17276987 . Kuroda F, Moss J, Vaughan M (Feb 2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma" . Proceedings of the National Academy of Sciences of the United States of America . 104 (9): 3201–6. doi :10.1073/pnas.0611696104 PMC 1805514 PMID 17360629 .
