호모 사피엔스 종의 단백질 코드 유전자
브레펠딘A억제구아닌뉴클레오티드교환단백질2 는 ARFGEF2유전자 에 [5] [6] 의해 인체 내에서 부호화되는 단백질 이다.
기능. ADP-리보실화인자 (ARF)는 세포 내 소포트래픽에 중요한 역할을 한다.이 유전자에 의해 코드된 단백질은 결합 GDP의 GTP 치환을 가속화함으로써 ARF의 활성화에 관여하며 골지 수송 에 관여한다. 구아닌-뉴클레오티드 교환 활성 및 브레펠딘 A [6] 억제를 담당할 수 있는 Sec7 도메인을 포함한다.
상호 작용 ARFGEF2는 ARFGEF1 ,[7] PRKAR1A [8] [8] 및 PRKAR2A 와 상호작용하는 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000124198 - 앙상블 , 2017년 5월 ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000074582 - 앙상블 , 2017년 5월 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors" . The Journal of Biological Chemistry . 274 (18): 12308–15. doi :10.1074/jbc.274.18.12308 . PMID 10212200 . ^ a b "Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)" . ^ Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex" . Proceedings of the National Academy of Sciences of the United States of America . 97 (6): 2567–72. doi :10.1073/pnas.97.6.2567 . PMC 15969 . PMID 10716990 . ^ a b Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)" . Proceedings of the National Academy of Sciences of the United States of America . 100 (4): 1627–32. doi :10.1073/pnas.0337678100 . PMC 149883 . PMID 12571360 . 외부 링크
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