ACP2

ACP2
식별자
에일리어스	ACP2, 산인산가수분해효소2, 리소좀, LAP
외부 ID	OMIM: 171650 MGI: 87882 HomoloGene: 1217 GeneCard: ACP2
유전자 위치(인간)
크르.	11번 염색체(인간)
끝.	47,248,906 bp
유전자 위치(마우스)
크르.	2번 염색체(마우스)
끝.	91,044,443 bp
RNA발현패턴
	상단 표시 위치:
	간우엽; ; 췌장체; ; 우부신; ; 좌부신; ; 자궁내막간질세포; ; 제주날 점막; ; 침샘; ; 십이지장; ; 위체; ; 비장;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	가수분해효소활성; 산인산가수분해효소활성;
셀룰러 컴포넌트	막의 적분 성분; 리소좀막; 리소좀; 리소좀 루멘; 세포외 엑소좀; 막;
생물학적 과정	골격계 발달; 리소좀 조직; 탈인산화;
	출처:아미고 / QuickGO
맞춤법
	53
	11432
	ENSG00000134575
	ENSMUSG00000002103
	P1117
	P24638
NM_001131064; NM_001302489; NM_001302490; NM_001302491; NM_001302492;
	NM_001610; NM_001357016
	NM_007387; NM_001357067
NP_001289418; NP_001289419; NP_001289420; NP_001289421; NP_001601;
	NP_001343945
	NP_031413; NP_001343996
	위키데이터
인간 보기/편집	마우스 표시/편집

리소좀산인산가수분해효소는 사람에게서 ACP2 유전자에 ^[5]^[6]의해 암호화되는 효소이다.

리소좀산인산가수분해효소는 알파와 베타 두 개의 서브유닛으로 구성되어 있으며 적혈구산인산가수분해효소와는 화학적으로, 유전적으로 구별된다.리소좀산 포스파타아제 2는 알코올과 인산염으로 직인산 모노에스테르를 가수분해하는 별개의 아이소엔자임 계열의 구성원이다.산인산가수분해효소 결핍은 ACP2(^[6]베타 서브유닛)와 ACP3(알파 서브유닛) 유전자의 돌연변이에 의해 발생한다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000134575 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000002103 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shows TB, Brown JA, Lalley PA (Dec 1976). "Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11". Cytogenet Cell Genet. 16 (1–5): 231–4. doi:10.1159/000130598. PMID 975882.
^ ^a ^b "Entrez Gene: ACP2 acid phosphatase 2, lysosomal".

추가 정보

Moss DW, Raymond FD, Wile DB (1995). "Clinical and biological aspects of acid phosphatase". Critical Reviews in Clinical Laboratory Sciences. 32 (4): 431–67. doi:10.3109/10408369509084690. PMID 7576159.
Gierek T, Lisiewicz T, Pilch J (1977). "Intracellular enzymatic response of lymphocytes and neutrophils in patients with cancer of the larynx". Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 104 (2): 208–15. PMID 69583.
Jones C, Kao FT (1979). "Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11". Hum. Genet. 45 (1): 1–10. doi:10.1007/BF00277567. PMID 730175. S2CID 21173503.
Geier C, von Figura K, Pohlmann R (1989). "Structure of the human lysosomal acid phosphatase gene". Eur. J. Biochem. 183 (3): 611–6. doi:10.1111/j.1432-1033.1989.tb21090.x. PMID 2776754.
Lemansky P, Gieselmann V, Hasilik A, von Figura K (1985). "Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts". J. Biol. Chem. 260 (15): 9023–30. doi:10.1016/S0021-9258(17)39452-8. PMID 3160696.
Pohlmann R, Krentler C, Schmidt B, et al. (1989). "Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment". EMBO J. 7 (8): 2343–50. doi:10.1002/j.1460-2075.1988.tb03078.x. PMC 457099. PMID 3191910.
Waheed A, Van Etten RL (1985). "Biosynthesis and processing of lysosomal acid phosphatase in cultured human cells". Arch. Biochem. Biophys. 243 (1): 274–83. doi:10.1016/0003-9861(85)90796-9. PMID 3904632.
Nadler HL, Egan TJ (1970). "Deficiency of lysosomal acid phosphatase. A new familial metabolic disorder". N. Engl. J. Med. 282 (6): 302–7. doi:10.1056/NEJM197002052820604. PMID 5410815.
Bass DA, Lewis JC, Szejda P, et al. (1981). "Activation of lysosomal acid phosphatase of eosinophil leukocytes". Lab. Invest. 44 (5): 403–9. PMID 6164873.
Chappard D, Alexandre C, Riffat G (1983). "Histochemical identification of osteoclasts. Review of current methods and reappraisal of a simple procedure for routine diagnosis on undecalcified human iliac bone biopsies". Basic and Applied Histochemistry. 27 (2): 75–85. PMID 6193776.
Moszczyński P, Lisiewicz J (1984). "Beta-glucuronidase of lymphocytes in ontogenetic development of man". Arch. Immunol. Ther. Exp. (Warsz.). 31 (2): 171–6. PMID 6651479.
Radzun HJ, Parwaresch MR (1981). "Isoelectric focusing pattern of acid phosphatase and acid esterase in human blood cells, including thymocytes, T lymphocytes, and B lymphocytes". Exp. Hematol. 8 (6): 737–41. PMID 6970673.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Whitelock RB, Fukuchi T, Zhou L, et al. (1997). "Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas". Invest. Ophthalmol. Vis. Sci. 38 (2): 529–34. PMID 9040486.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Obermüller S, Kiecke C, von Figura K, Höning S (2002). "The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targeting to lysosomes". J. Cell Sci. 115 (Pt 1): 185–94. doi:10.1242/jcs.115.1.185. PMID 11801736.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

외부 링크

UCSC Genome Browser의 인간 ACP2 게놈 위치 및 ACP2 유전자 상세 페이지.

인간 염색체 11번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000134575 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG00000002103 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid975882-5] Shows TB, Brown JA, Lalley PA (Dec 1976). "Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11". Cytogenet Cell Genet. 16 (1–5): 231–4. doi:10.1159/000130598. PMID 975882.

[entrez-6] "Entrez Gene: ACP2 acid phosphatase 2, lysosomal".

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