α-카디놀

α-Cadinol
α-카디놀
Alpha-Cadinol.svg
이름
IUPAC 이름
캐딘-4-en-10-ol
시스템 IUPAC 이름
(1R,4S,4aR,8aR)-1,6-디메틸-4-프로판-2-일-3,4,4a,7,8a-헥사히드로-2H-나프탈렌-1-ol
식별자
3D 모델(JSmol)
체비
켐스파이더
유니
  • InChI=1S/C15H26O/c1-10(2)12-7-8-15(4,16)14-6-5-11(3)9-13)14/h9-10,12-14,16H,5-8H2,1-4H3/t12-13/14+15,14+15
    키: LHYHMMYTDARSZ-BYNSBNAKSA-N
  • InChI=1/C15H26O/c1-10(2)12-7-15(4,16)14-6-5-11(3)9-13)14/h9-10,12-14,16H,5-8H2,1-4H3/t12,13-14,0.15+15
    키: LHYHM RYTDARSZ-BYNSBNAKBA
  • CC1=C[C@H]2[C@H](CC[C@@@]([C@H]2CC1)(C)O)C(C)C
특성.
C
15H
26O
몰 질량 222.37 g/g
외모 백색 결정질
녹는점 73 ~ 74 °C (163 ~165 °F, 346 ~347 K)
달리 명시되지 않은 한 표준 상태(25°C[77°F], 100kPa)의 재료에 대한 데이터가 제공됩니다.

α-카디놀 또는 10α-히드록시-4-카디넨은 유기화합물인 세스키테르페노이드 [1][2]알코올이다.

자연발생

이 화합물은 에센셜 오일과 많은 식물의 추출물에서 발견됩니다.

생물학적 활동

α-Cadinol은 항균[12] 및 간보호 [14]작용을 한다고 알려져 약제 내성 [5]결핵의 가능한 치료제로 제안되었다.

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레퍼런스

  1. ^ Borg-Karlson, A (1981). "Configurations and conformations of torreyol (δ-cadinol), α-cadinol, T-muurolol and T-cadinol". Tetrahedron. 37 (22): 425–430. doi:10.1016/S0040-4020(01)92031-9.
  2. ^ V. Herout; V. Sýkora (1958). "The chemistry of cadinenes and cadinols". Tetrahedron. 4 (3–4): 246–255. doi:10.1016/0040-4020(58)80046-0.
  3. ^ Boligon, AA; Schwanz, TG; Piana, M; Bandeira, RV; Frohlich, JK; Brum, TF; Zadra, M; Athayde, ML (2012). "Chemical composition and antioxidant activity of the essential oil of Tabernaemontana catharinensis A. DC. Leaves". Natural Product Research. 27: 1. doi:10.1080/14786419.2011.653971. PMID 22273350.
  4. ^ Ho, CL; Liao, PC; Wang, EI; Su, YC (2011). "Composition and antimicrobial activity of the leaf and twig oils of Litsea acutivena from Taiwan". Natural Product Communications. 6 (11): 1755–8. doi:10.1177/1934578X1100601145. PMID 22224304.
  5. ^ a b Bueno, J; Escobar, P; Martínez, JR; Leal, SM; Stashenko, EE (2011). "Composition of three essential oils, and their mammalian cell toxicity and antimycobacterial activity against drug resistant-tuberculosis and nontuberculous mycobacteria strains". Natural Product Communications. 6 (11): 1743–8. PMID 22224302.
  6. ^ De Freitas, JG; Da Camara, CA; De Moraes, MM; Da Silva, HC (2011). "Volatile constituents of two species of Protium from the Atlantic rainforest in the state of Pernambuco, Brazil". Natural Product Communications. 6 (11): 1727–30. PMID 22224298.
  7. ^ Muriel, KA; Félix, TZ; Figueredo, G; Chalard, P; n'Guessan, YT (2011). "Essential oil of three Uvaria species from Ivory Coast". Natural Product Communications. 6 (11): 1715–8. PMID 22224295.
  8. ^ Lago, JH; Souza, ED; Mariane, B; Pascon, R; Vallim, MA; Martins, RC; Baroli, AA; Carvalho, BA; et al. (2011). "Chemical and biological evaluation of essential oils from two species of Myrtaceae - Eugenia uniflora L. And Plinia trunciflora (O. Berg) Kausel". Molecules (Basel, Switzerland). 16 (12): 9827–37. doi:10.3390/molecules16129827. PMC 6264170. PMID 22117172.
  9. ^ Firozy, M; Talebpour, Z; Sonboli, A (2011). "Essential oil composition and antioxidant activities of the various extracts of Tanacetum sonbolii Mozaff. (Asteraceae) from Iran". Natural Product Research. 26: 1. doi:10.1080/14786419.2011.636746. PMID 22115413.
  10. ^ Liu, CJ; Zhang, SQ; Zhang, JS; Liang, Q; Li, DS (2011). "Chemical composition and antioxidant activity of essential oil from berries of Schisandra chinensis (Turcz.) Baill". Natural Product Research. 26: 1. doi:10.1080/14786419.2011.636745. PMID 22103398.
  11. ^ Yang, Y; Xiao, Y; Liu, B; Fang, X; Yang, W; Xu, J (2011). "Comparison of headspace solid-phase microextraction with conventional extraction for the analysis of the volatile components in Melia azedarach". Talanta. 86: 356–61. doi:10.1016/j.talanta.2011.09.028. PMID 22063551.
  12. ^ a b Ho, CL; Liao, PC; Wang, EI; Su, YC (2011). "Composition and antifungal activities of the leaf essential oil of Neolitsea parvigemma from Taiwan". Natural Product Communications. 6 (9): 1357–60. PMID 21941915.
  13. ^ Z. C. Gazim; A. C. Amorim; A. M. Hovell; C. M. Rezende; I. A. Nascimento; G. A. Ferreira; D. A. Cortez (2010). "Seasonal variation, chemical composition, and analgesic and antimicrobial activities of the essential oil from leaves of Tetradenia riparia (Hochst.) Codd in southern Brazil". Molecules. 15 (8): 5509–5524. doi:10.3390/molecules15085509. PMC 6257709. PMID 20714310.
  14. ^ Tung, Y. T.; Huang, C. C.; Ho, S. T.; Kuo, Y. H.; Lin, C. C.; Lin, C. T.; Wu, J. H. (2011). "Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute hepatitis in mice". J. Agric. Food Chem. 59: 8117–8123. doi:10.1080/10412905.1999.9712005.