SPINT2

SPINT2
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	4U32
식별자
에일리어스	SPINT2, DIAR3, HAI-2, HAI2, Kop, PB, 세린펩티드가수분해효소억제제, 쿠니츠형, 2, 세린펩티드가수분해효소억제제, 쿠니츠형
외부 ID	OMIM: 605124 MGI: 1338031 HomoloGene: 7955 GenCard: SPINT2
유전자 위치(인간)
크르.	19번 염색체(인간)
끝.	38,292,615 bp
유전자 위치(마우스)
크르.	7번 염색체(쥐)
끝.	28,981,337 bp
RNA발현패턴
	상단 표시 위치:
	이하선; ; 뇌하수체; ; 뇌하수체 전엽; ; 갑상선 좌엽; ; 갑상선 우엽; ; 우측 자궁관; ; 안검결막; ; 상행 대동맥; ; 직장; ; 기관;
	상단 표시 위치:
	좌결장; ; 턱밑샘; ; 장내 융모; ; 소장의 리베르쿤 지하실; ; 유문성 항문; ; 십이지장; ; 이하선; ; 회장; ; 눈물샘; ; 빈 창자;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	펩티드가수분해효소억제활성; 엔도펩티드가수분해효소억제활성; 세린형 엔도펩티드가수분해효소억제제활성; 단백질 결합;
셀룰러 컴포넌트	세포질; 막의 적분 성분; 세포외 영역; 막; 혈장막;
생물학적 과정	세포운동성의 음성조절; 펩티드가수분해효소활성음성조절; 세포접착부정조절; 세포 극성의 확립 또는 유지; 신경 전구 세포 확산의 부정적인 규정이다.; 신경관 폐쇄; endopeptidase 활동의 부정적인 규정이다.; 태반 분지에 관여하는 상피 세포 형태 형성; BMP자극에 세포의 반응이다.; 기저막 구성;
	출처:아미고 / QuickGO
맞춤법
	10653
	20733
	ENSG00000167642
	ENSMUSG000074227
	O43291
	Q9WU03
	NM_021102; NM_001166103
	NM_001082548; NM_011464
	NP_001159575; NP_066925
	NP_001076017; NP_035594
	위키데이터
인간 보기/편집	마우스 표시/편집

쿠니츠형 단백질분해효소억제제2는 사람에게 SPINT2 ^[5]^[6]^[7]유전자에 의해 암호화되는 효소억제제이다.SPINT2는 세린 단백질 분해 효소를 억제하기 위해 두 개의 세포 외 Kunitz 도메인을 가진 트랜스막 단백질이다.이 유전자는 활성 간세포 증식 인자의 형성을 방해하는 HGF 활성화 인자를 억제하여 종양 억제제로 추정됩니다.SPINT2의 돌연변이는 선천성 나트륨 설사(CSD)를 일으킬 수 있습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000167642 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000074227 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marlor CW, Delaria KA, Davis G, Muller DK, Greve JM, Tamburini PP (May 1997). "Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains". The Journal of Biological Chemistry. 272 (18): 12202–8. doi:10.1074/jbc.272.18.12202. PMID 9115294.
^ Kawaguchi T, Qin L, Shimomura T, Kondo J, Matsumoto K, Denda K, Kitamura N (Oct 1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor". The Journal of Biological Chemistry. 272 (44): 27558–64. doi:10.1074/jbc.272.44.27558. PMID 9346890.
^ "Entrez Gene: SPINT2 serine peptidase inhibitor, Kunitz type, 2".

추가 정보

Morelle W, Capon C, Balduyck M, Sautiere P, Kouach M, Michalski C, Fournet B, Mizon J (Apr 1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor". European Journal of Biochemistry. 221 (2): 881–8. doi:10.1111/j.1432-1033.1994.tb18803.x. PMID 7513643.
Mizon C, Balduyck M, Albani D, Michalski C, Burnouf T, Mizon J (Mar 1996). "Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains". Journal of Immunological Methods. 190 (1): 61–70. doi:10.1016/0022-1759(95)00257-X. PMID 8601712.
Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, Büchler M, Adler G, Lehrach H (Oct 1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–30. PMID 8895530.
Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N (Mar 1997). "Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor". The Journal of Biological Chemistry. 272 (10): 6370–6. doi:10.1074/jbc.272.10.6370. PMID 9045658.
Blom AM, Thuveson M, Fries E (Nov 1997). "Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells". The Biochemical Journal. 328 ( Pt 1) (Pt 1): 185–91. doi:10.1042/bj3280185. PMC 1218904. PMID 9359851.
Müller-Pillasch F, Wallrapp C, Bartels K, Varga G, Friess H, Büchler M, Adler G, Gress TM (Jan 1998). "Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1395 (1): 88–95. doi:10.1016/s0167-4781(97)00129-2. PMID 9434156.
Kataoka H, Shimomura T, Kawaguchi T, Hamasuna R, Itoh H, Kitamura N, Miyazawa K, Koono M (Dec 2000). "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment". The Journal of Biological Chemistry. 275 (51): 40453–62. doi:10.1074/jbc.M006412200. PMID 11013244.
Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M (Oct 2001). "Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes". Biochemical and Biophysical Research Communications. 288 (2): 390–9. doi:10.1006/bbrc.2001.5767. PMID 11606055.
Suzuki M, Kobayashi H, Fujie M, Nishida T, Takigawa M, Kanayama N, Terao T (Mar 2002). "Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells". The Journal of Biological Chemistry. 277 (10): 8022–32. doi:10.1074/jbc.M108545200. PMID 11777908.
Kobayashi H, Suzuki M, Kanayama N, Nishida T, Takigawa M, Terao T (Aug 2002). "Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade". European Journal of Biochemistry. 269 (16): 3945–57. doi:10.1046/j.1432-1033.2002.03068.x. PMID 12180971.
Mizon C, Piva F, Queyrel V, Balduyck M, Hachulla E, Mizon J (Jun 2002). "Urinary bikunin determination provides insight into proteinase/proteinase inhibitor imbalance in patients with inflammatory diseases". Clinical Chemistry and Laboratory Medicine. 40 (6): 579–86. doi:10.1515/CCLM.2002.100. PMID 12211652. S2CID 22630736.
Isogai R, Matsukura A, Aragane Y, Maeda A, Matsukura M, Yudate T, Sugihara K, Takahashi M, Aisu K, Tezuka T (Dec 2002). "Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis". Archives of Dermatological Research. 294 (9): 387–92. doi:10.1007/s00403-002-0336-9. PMID 12522575. S2CID 9514861.
Yamauchi M, Itoh H, Naganuma S, Koono M, Hasui Y, Osada Y, Kataoka H (Dec 2002). "Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: identification of a distinct transcription start site for the HAI-2 gene in testis". Biological Chemistry. 383 (12): 1953–7. doi:10.1515/BC.2002.220. PMID 12553733. S2CID 19734313.
Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, Saga Y, Suzuki M, Itoh H, Terao T (Apr 2003). "Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin". International Journal of Cancer. 104 (3): 289–302. doi:10.1002/ijc.10950. hdl:10271/1250. PMID 12569552. S2CID 84583247.
Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, Saga Y, Suzuki M, Itoh H, Terao T (Apr 2003). "Bikunin target genes in ovarian cancer cells identified by microarray analysis". The Journal of Biological Chemistry. 278 (17): 14640–6. doi:10.1074/jbc.M300239200. PMID 12571229.
Schuster JM, Longo M, Nelson PS (Sep 2003). "Differential expression of bikunin (HAI-2/PB), a proposed mediator of glioma invasion, by demethylation treatment". Journal of Neuro-Oncology. 64 (3): 219–25. doi:10.1023/A:1025674227750. PMID 14558597. S2CID 22607445.
Fukai K, Yokosuka O, Chiba T, Hirasawa Y, Tada M, Imazeki F, Kataoka H, Saisho H (Dec 2003). "Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma". Cancer Research. 63 (24): 8674–9. PMID 14695180.

외부 링크

PDB for UniProt: O43291(Kunitz-type protease inhibiter 2) PDBe-KB의 모든 구조 정보의 개요.

인간 염색체 19번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000167642 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000074227 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9115294-5] Marlor CW, Delaria KA, Davis G, Muller DK, Greve JM, Tamburini PP (May 1997). "Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains". The Journal of Biological Chemistry. 272 (18): 12202–8. doi:10.1074/jbc.272.18.12202. PMID 9115294.

[pmid9346890-6] Kawaguchi T, Qin L, Shimomura T, Kondo J, Matsumoto K, Denda K, Kitamura N (Oct 1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor". The Journal of Biological Chemistry. 272 (44): 27558–64. doi:10.1074/jbc.272.44.27558. PMID 9346890.

[entrez-7] "Entrez Gene: SPINT2 serine peptidase inhibitor, Kunitz type, 2".

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SPINT2

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레퍼런스

추가 정보

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