신데칸-2

SDC2
식별자
에일리어스	SDC2, CD362, HSPG, HSPG1, SIND2, syndecan 2
외부 ID	OMIM: 142460 MGI: 1349165 HomoloGene: 2253 GeneCard: SDC2
유전자 위치(인간)
크르.	8번 염색체(인간)
끝.	96,611,790 bp
유전자 위치(마우스)
크르.	15번 염색체(쥐)
끝.	33,035,081 bp
RNA발현패턴
	상단 표시 위치:
	경골; ; 아킬레스건; ; 활액관절; ; 망막 색소 상피; ; 갑상선 좌엽; ; 우관상 동맥; ; 갑상선 우엽; ; 슬와 동맥; ; 복정맥; ; 상행 대동맥;
	상단 표시 위치:
	칼바리아; ; 대퇴골체; ; 섬모체; ; 홍채; ; 발목; ; 망막 색소 상피; ; 간좌엽; ; 뇌하수체; ; 복측 피개부; ; 중앙 융기;
	추가 참조 표현식 데이터
	; ; ; ;
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	PDZ 도메인바인딩; 단백질 결합; 동일단백질결합;
셀룰러 컴포넌트	막의 적분 성분; 막; 혈장막; 리소좀 루멘; 골지 루멘; 소포체내강; 세포 표면; 세포외 매트릭스; 콜라겐 함유 세포외 매트릭스;
생물학적 과정	글리코사미노글리칸 대사 과정; 세포 분화; 에프린수용체신호경로; 신경계의 발달; 레티노이드 대사 과정; 수상돌기 형태 형성 조절; 생물 발광; 글리코사미노글리칸 이화 과정; 글리코사미노글리칸생합성법; 백혈구 이동; 발육 후 단백질 수식; 세포이동; 수상돌기 형태 형성; 생물학적 과정;
	출처:아미고 / QuickGO
맞춤법
	6383
	15529
	ENSG00000169439
	ENSMUSG000022261
	P34741
	P43407
	NM_002998
	NM_008304
	NP_002989
	NP_032330
	위키데이터
인간 보기/편집	마우스 표시/편집

Syndecan-2는 SDC2 ^[5]유전자에 의해 인간에게 암호화되는 단백질이다.

기능.

이 유전자에 의해 코드된 단백질은 트랜스막(타입 I) 헤파란 황산 프로테오글리칸이며 신데칸 프로테오글리칸 패밀리의 구성원이다.Syndecan은 세포 결합, 세포 신호 전달, 세포 골격 조직 및 Syndecan 수용체를 매개하는 HIV-1 tat 단백질의 내부화를 위해 필요하다.Syndecan-2 단백질은 일체형 막 단백질로 기능하며 세포외 매트릭스 단백질 수용체를 통해 세포 증식, 세포 이동 및 세포 매트릭스 상호작용에 참여한다.변형된 syndecan-2 발현이 여러 다른 ^[6]종양 유형에서 발견되었습니다.

상호 작용

SDC2는 다음과 같은 기능을 갖추고 있습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000169439 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000022261 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ David G, Bai XM, Van der Schueren B, Marynen P, Cassiman JJ, Van den Berghe H (June 1994). "Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development". Development. 119 (3): 841–54. doi:10.1242/dev.119.3.841. PMID 8187643.
^ "Entrez Gene: SDC2 syndecan 2".
^ Maximov A, Tang TS, Bezprozvanny I (February 2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. 22 (2): 271–83. doi:10.1016/s1044-7431(02)00027-1. PMID 12676536. S2CID 2317354.
^ Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM, Wood DF (July 1998). "Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells". J. Cell Biol. 142 (1): 129–38. doi:10.1083/jcb.142.1.129. PMC 2133028. PMID 9660868.
^ Utani A, Nomizu M, Matsuura H, Kato K, Kobayashi T, Takeda U, Aota S, Nielsen PK, Shinkai H (August 2001). "A unique sequence of the laminin alpha 3 G domain binds to heparin and promotes cell adhesion through syndecan-2 and -4". J. Biol. Chem. 276 (31): 28779–88. doi:10.1074/jbc.M101420200. PMID 11373281.
^ Granés F, Urena JM, Rocamora N, Vilaró S (April 2000). "Ezrin links syndecan-2 to the cytoskeleton". J. Cell Sci. 113 ( Pt 7) (7): 1267–76. doi:10.1242/jcs.113.7.1267. PMID 10704377.

추가 정보

Mahley RW, Ji ZS (1999). "Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E." J. Lipid Res. 40 (1): 1–16. doi:10.1016/S0022-2275(20)33334-4. PMID 9869645.
Labarrere CA, Pitts D, Halbrook H, Faulk WP (1992). "Natural anticoagulant pathways in normal and transplanted human hearts". J. Heart Lung Transplant. 11 (2 Pt 1): 342–7. PMID 1315572.
Marynen P, Zhang J, Cassiman JJ, Van den Berghe H, David G (1989). "Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts". J. Biol. Chem. 264 (12): 7017–24. doi:10.1016/S0021-9258(18)83534-7. PMID 2523388.
Sage H, Vernon RB, Funk SE, Everitt EA, Angello J (1989). "SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix". J. Cell Biol. 109 (1): 341–56. doi:10.1083/jcb.109.1.341. PMC 2115491. PMID 2745554.
Lories V, De Boeck H, David G, Cassiman JJ, Van den Berghe H (1987). "Heparan sulfate proteoglycans of human lung fibroblasts. Structural heterogeneity of the core proteins of the hydrophobic cell-associated forms". J. Biol. Chem. 262 (2): 854–9. doi:10.1016/S0021-9258(19)75865-7. PMID 2948951.
Brown KJ, Parish CR (1994). "Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor". Biochemistry. 33 (46): 13918–27. doi:10.1021/bi00250a047. PMID 7524669.
Bolton P, Powell J, Rutter M, Buckle V, Yates JR, Ishikawa-Brush Y, Monaco AP (1995). "Autism, mental retardation, multiple exostoses and short stature in a female with 46,X,t(X;8)(p22.13;q22.1)". Psychiatr. Genet. 5 (2): 51–5. doi:10.1097/00041444-199522000-00001. PMID 7551962. S2CID 45132642.
Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence". Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7941–5. Bibcode:1993PNAS...90.7941B. doi:10.1073/pnas.90.17.7941. PMC 47263. PMID 7690138.
Lyon M, Deakin JA, Mizuno K, Nakamura T, Gallagher JT (1994). "Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants". J. Biol. Chem. 269 (15): 11216–23. doi:10.1016/S0021-9258(19)78113-7. PMID 8157651.
Albini A, Benelli R, Presta M, Rusnati M, Ziche M, Rubartelli A, Paglialunga G, Bussolino F, Noonan D (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289–97. PMID 8570206.
Soussi-Yanicostas N, Hardelin JP, Arroyo-Jimenez MM, Ardouin O, Legouis R, Levilliers J, Traincard F, Betton JM, Cabanié L, Petit C (1997). "Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system". J. Cell Sci. 109 (7): 1749–57. doi:10.1242/jcs.109.7.1749. PMID 8832397.
Christa L, Carnot F, Simon MT, Levavasseur F, Stinnakre MG, Lasserre C, Thepot D, Clement B, Devinoy E, Brechot C (1997). "HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells". Am. J. Physiol. 271 (6 Pt 1): G993–1002. doi:10.1152/ajpgi.1996.271.6.G993. PMID 8997243.
Rusnati M, Coltrini D, Oreste P, Zoppetti G, Albini A, Noonan D, d'Adda di Fagagna F, Giacca M, Presta M (1997). "Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size". J. Biol. Chem. 272 (17): 11313–20. doi:10.1074/jbc.272.17.11313. PMID 9111037.
Oh ES, Couchman JR, Woods A (1997). "Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain". Arch. Biochem. Biophys. 344 (1): 67–74. doi:10.1006/abbi.1997.0180. PMID 9244383.
Ishikawa-Brush Y, Powell JF, Bolton P, Miller AP, Francis F, Willard HF, Lehrach H, Monaco AP (1997). "Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene". Hum. Mol. Genet. 6 (8): 1241–50. doi:10.1093/hmg/6.8.1241. PMID 9259269.
Chang HC, Samaniego F, Nair BC, Buonaguro L, Ensoli B (1997). "HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region". AIDS. 11 (12): 1421–31. doi:10.1097/00002030-199712000-00006. PMID 9342064. S2CID 7648619.
Grootjans JJ, Zimmermann P, Reekmans G, Smets A, Degeest G, Dürr J, David G (1998). "Syntenin, a PDZ protein that binds syndecan cytoplasmic domains". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13683–8. doi:10.1073/pnas.94.25.13683. PMC 28366. PMID 9391086.
Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM, Wood DF (1998). "Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells". J. Cell Biol. 142 (1): 129–38. doi:10.1083/jcb.142.1.129. PMC 2133028. PMID 9660868.

인간 염색체 8번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000169439 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000022261 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8187643-5] David G, Bai XM, Van der Schueren B, Marynen P, Cassiman JJ, Van den Berghe H (June 1994). "Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development". Development. 119 (3): 841–54. doi:10.1242/dev.119.3.841. PMID 8187643.

[entrez-6] "Entrez Gene: SDC2 syndecan 2".

[pmid12676536-7] Maximov A, Tang TS, Bezprozvanny I (February 2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. 22 (2): 271–83. doi:10.1016/s1044-7431(02)00027-1. PMID 12676536. S2CID 2317354.

[pmid9660868-8] Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM, Wood DF (July 1998). "Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells". J. Cell Biol. 142 (1): 129–38. doi:10.1083/jcb.142.1.129. PMC 2133028. PMID 9660868.

[pmid11373281-9] Utani A, Nomizu M, Matsuura H, Kato K, Kobayashi T, Takeda U, Aota S, Nielsen PK, Shinkai H (August 2001). "A unique sequence of the laminin alpha 3 G domain binds to heparin and promotes cell adhesion through syndecan-2 and -4". J. Biol. Chem. 276 (31): 28779–88. doi:10.1074/jbc.M101420200. PMID 11373281.

[pmid10704377-10] Granés F, Urena JM, Rocamora N, Vilaró S (April 2000). "Ezrin links syndecan-2 to the cytoskeleton". J. Cell Sci. 113 ( Pt 7) (7): 1267–76. doi:10.1242/jcs.113.7.1267. PMID 10704377.

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신데칸-2

네임스페이스

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목차

기능.

상호 작용

레퍼런스

추가 정보