RIPK2
RIPK2
수용체 상호작용 세린/트레오닌단백질인산화효소2는 RIPK2 [5][6][7]유전자에 의해 인체 내에서 코드되는 효소이다.
이 유전자는 세린/트레오닌 단백질 키나아제 수용체 상호작용단백질(RIP) 계열의 멤버를 코드한다.코드화된 단백질은 C 말단 카스파아제 모집 도메인(CARD)을 포함하고 선천적 면역 경로와 적응적 면역 경로 모두에서 신호 복합체의 구성요소이다.NF-γB의 강력한 활성화제이며 다양한 [7]자극에 반응하여 아포토시스의 유도제이다.
상호 작용
RIPK2는 BIRC2와 [6][8]상호작용하는 것으로 나타났습니다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000104312 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000041135 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Inohara N, del Peso L, Koseki T, Chen S, Nunez G (Jun 1998). "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis". J Biol Chem. 273 (20): 12296–300. doi:10.1074/jbc.273.20.12296. PMID 9575181.
- ^ a b Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J (Nov 1998). "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1". Curr Biol. 8 (15): 885–8. doi:10.1016/S0960-9822(07)00352-1. PMID 9705938. S2CID 1235278.
- ^ a b "Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2".
- ^ McCarthy, J V; Ni J; Dixit V M (Jul 1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. UNITED STATES. 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. ISSN 0021-9258. PMID 9642260.
추가 정보
- Medzhitov R, Janeway C (2000). "Innate immune recognition: mechanisms and pathways". Immunol. Rev. 173: 89–97. doi:10.1034/j.1600-065X.2000.917309.x. PMID 10719670. S2CID 20844121.
- Dufner A, Mak TW (2006). "CARD tricks: controlling the interactions of CARD6 with RICK and microtubules". Cell Cycle. 5 (8): 797–800. doi:10.4161/cc.5.8.2635. PMID 16582588.
- McCarthy JV, Ni J, Dixit VM (1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. PMID 9642260.
- Bertin J, Nir WJ, Fischer CM, et al. (1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB". J. Biol. Chem. 274 (19): 12955–8. doi:10.1074/jbc.274.19.12955. PMID 10224040.
- Inohara N, Koseki T, del Peso L, et al. (1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB". J. Biol. Chem. 274 (21): 14560–7. doi:10.1074/jbc.274.21.14560. PMID 10329646.
- Navas TA, Baldwin DT, Stewart TA (1999). "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase". J. Biol. Chem. 274 (47): 33684–90. doi:10.1074/jbc.274.47.33684. PMID 10559258.
- Inohara N, Koseki T, Lin J, et al. (2000). "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways". J. Biol. Chem. 275 (36): 27823–31. doi:10.1074/jbc.M003415200. PMID 10880512.
- Ogura Y, Inohara N, Benito A, et al. (2001). "Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB". J. Biol. Chem. 276 (7): 4812–8. doi:10.1074/jbc.M008072200. PMID 11087742.
- Lee SH, Stehlik C, Reed JC (2001). "Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing". J. Biol. Chem. 276 (37): 34495–500. doi:10.1074/jbc.M101415200. PMID 11432859.
- Khursigara G, Bertin J, Yano H, et al. (2001). "A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2". J. Neurosci. 21 (16): 5854–63. doi:10.1523/JNEUROSCI.21-16-05854.2001. PMC 6763175. PMID 11487608.
- Andersson L, Scharin Tang M (2015). "Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia". Cardiovasc. Res. 107 (4): 478–86. doi:10.1093/cvr/cvv186. PMID 26130752.
- Druilhe A, Srinivasula SM, Razmara M, et al. (2001). "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins". Cell Death Differ. 8 (6): 649–57. doi:10.1038/sj.cdd.4400881. PMID 11536016.
- Chin AI, Dempsey PW, Bruhn K, et al. (2002). "Involvement of receptor-interacting protein 2 in innate and adaptive immune responses". Nature. 416 (6877): 190–4. Bibcode:2002Natur.416..190C. doi:10.1038/416190a. PMID 11894097. S2CID 4405035.
- Kobayashi K, Inohara N, Hernandez LD, et al. (2002). "RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems" (PDF). Nature. 416 (6877): 194–9. Bibcode:2002Natur.416..194K. doi:10.1038/416194a. hdl:2027.42/62842. PMID 11894098. S2CID 4363636.
- Munz B, Hildt E, Springer ML, Blau HM (2002). "RIP2, a Checkpoint in Myogenic Differentiation". Mol. Cell. Biol. 22 (16): 5879–86. doi:10.1128/MCB.22.16.5879-5886.2002. PMC 133983. PMID 12138198.
- Yoo NJ, Park WS, Kim SY, et al. (2003). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochem. Biophys. Res. Commun. 299 (4): 652–8. doi:10.1016/S0006-291X(02)02714-6. PMID 12459189.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chen YR, Clark AC (2003). "Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK". Biochemistry. 42 (20): 6310–20. doi:10.1021/bi0340752. PMID 12755636.
