PIK3C2B

PIK3C2B
식별자
에일리어스	PIK3C2B, C2-PI3K, 포스파티딜리노시톨-4-인산3-키나아제 촉매 서브유닛2형 베타
외부 ID	OMIM : 602838 MGI : 2685045 HomoloGene : 20582 GenCard : PIK3C2B
유전자 위치(인간)
크르.	1번 염색체(인간)
끝.	204,494,805 bp
유전자 위치(마우스)
크르.	1번 염색체(마우스)
끝.	133,036,425 bp
RNA발현패턴
	상단 표시 위치:
	췌관 세포; ; 미주신경의 하부 신경절; ; 유문; ; 니플; ; 대정맥; ; 복측 피개부; ; 내장 흉막; ; 천측두동맥; ; 시상하핵; ; 흉선;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	트랜스페라아제 활성; 뉴클레오티드 결합; 지질인산화효소활성; 1-아미타디딜이노시톨-3-아미타디올활성; 1-아미타디딜이노시톨-4-인산3-아미타디딜이노시톨; 키나아제활성; GO:0001948 단백질 결합; 포스파티딜이노시톨결합; ATP 결합;
셀룰러 컴포넌트	포스파티딜이노시톨3-아크롬복합체; 막; 세포막내소기관; 혈장막; 세포내 소포; 소포체; 핵; 핵소체; 세포; 세포질;
생물학적 과정	단백질인산화효소B신호전달; 인산화; 포스파티딜이노시톨인산생합성법; 포스파티딜이노시톨 매개 시그널링; 기아에 대한 세포 반응; 포스파티딜이노시톨-3-인산생합성법; 오토파고솜 조직; 거시 자동 식도; 포스파티딜이노시톨3가시그널링; 세포이동; 생물학적 과정; 포스파티딜이노시톨생합성법;
	출처:아미고 / QuickGO
맞춤법
	5287
	240752
	ENSG00000133056
	ENSMUSG000026447
	O00750
	없음
	NM_002646; NM_001377334; NM_001377335
	NM_001099276
	NP_002637; NP_001364263; NP_001364264
	없음
	위키데이터
인간 보기/편집	마우스 표시/편집

포스파티딜이노시톨-4-인산3-키나아제C2 도메인 함유 베타폴리펩타이드는 PIK3C2B ^[5]^[6]^[7]유전자에 의해 인체 내에서 코드되는 효소이다.

기능.

이 유전자에 의해 암호화된 단백질은 포스포이노시티드 3-키나아제(PI3K) 계열에 속합니다.PI3-키나아제는 세포 증식, 종양 유발 변환, 세포 생존, 세포 이동 및 세포 내 단백질 전달과 관련된 신호 경로에서 역할을 합니다.이 단백질은 등급 II PI3-키나아제 특징인 C-말단 C2 도메인과 함께 지질 키나아제 촉매 도메인을 포함한다.C2 도메인은 막으로의 단백질 전이를 매개하는 칼슘 의존성 인지질 결합 모티브로 작용하며 단백질-단백질 상호작용을 매개할 수도 있다.이 단백질의 PI3-키나아제 활성은 억제제인 볼트마닌의 낮은 나노몰 수준에 민감하다.이 단백질의 C2 도메인은 인지질을 결합하는 것으로 나타났지만 Ca는 결합하지²⁺ 않았으며, 이는 이 효소가 칼슘 비의존적인 ^[7]방식으로 기능할 수 있음을 시사한다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000133056 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000026447 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brown RA, Ho LK, Weber-Hall SJ, Shipley JM, Fry MJ (Apr 1997). "Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K". Biochemical and Biophysical Research Communications. 233 (2): 537–44. doi:10.1006/bbrc.1997.6495. PMID 9144573.
^ Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD (Dec 1998). "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity". The Journal of Biological Chemistry. 273 (49): 33082–90. doi:10.1074/jbc.273.49.33082. PMID 9830063.
^ ^a ^b "Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide".

추가 정보

Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (Nov 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". Journal of Leukocyte Biology. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231.
Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H (Oct 1994). "Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo". Oncogene. 9 (10): 2991–8. PMID 8084603.
Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S (Sep 1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". The Journal of Biological Chemistry. 271 (38): 22961–4. doi:10.1074/jbc.271.38.22961. PMID 8798481.
Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H (Jun 1997). "The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase". Oncogene. 14 (25): 3067–72. doi:10.1038/sj.onc.1201153. PMID 9223670.
Mazerolles F, Barbat C, Fischer A (Sep 1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". European Journal of Immunology. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID 9341793. S2CID 33397908.
Borgatti P, Zauli G, Colamussi ML, Gibellini D, Previati M, Cantley LL, Capitani S (Nov 1997). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". European Journal of Immunology. 27 (11): 2805–11. doi:10.1002/eji.1830271110. PMID 9394803. S2CID 6303471.
Borgatti P, Zauli G, Cantley LC, Capitani S (Jan 1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochemical and Biophysical Research Communications. 242 (2): 332–7. doi:10.1006/bbrc.1997.7877. PMID 9446795.
Milani D, Mazzoni M, Zauli G, Mischiati C, Gibellini D, Giacca M, Capitani S (Jul 1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. doi:10.1097/00002030-199811000-00008. PMID 9708406. S2CID 25758704.
Jauliac S, Mazerolles F, Jabado N, Pallier A, Bernard F, Peake J, Fischer A, Hivroz C (Oct 1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". European Journal of Immunology. 28 (10): 3183–91. doi:10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A. PMID 9808187.
Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J (Jun 2000). "Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors". Molecular and Cellular Biology. 20 (11): 3817–30. doi:10.1128/MCB.20.11.3817-3830.2000. PMC 85707. PMID 10805725.
Park IW, Wang JF, Groopman JE (Jan 2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes". Blood. 97 (2): 352–8. doi:10.1182/blood.V97.2.352. PMID 11154208.
Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (Feb 2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB Journal. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
Wheeler M, Domin J (Oct 2001). "Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2". Molecular and Cellular Biology. 21 (19): 6660–7. doi:10.1128/MCB.21.19.6660-6667.2001. PMC 99811. PMID 11533253.
Deregibus MC, Cantaluppi V, Doublier S, Brizzi MF, Deambrosis I, Albini A, Camussi G (Jul 2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells". The Journal of Biological Chemistry. 277 (28): 25195–202. doi:10.1074/jbc.M200921200. PMID 11994280.
Cook JA, August A, Henderson AJ (Jul 2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism". Journal of Immunology. 169 (1): 254–60. doi:10.4049/jimmunol.169.1.254. PMID 12077252.
Arcaro A, Khanzada UK, Vanhaesebroeck B, Tetley TD, Waterfield MD, Seckl MJ (Oct 2002). "Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation". The EMBO Journal. 21 (19): 5097–108. doi:10.1093/emboj/cdf512. PMC 129034. PMID 12356726.
Visnjić D, Crljen V, Curić J, Batinić D, Volinia S, Banfić H (Oct 2002). "The activation of nuclear phosphoinositide 3-kinase C2beta in all-trans-retinoic acid-differentiated HL-60 cells". FEBS Letters. 529 (2–3): 268–74. doi:10.1016/S0014-5793(02)03357-4. PMID 12372612. S2CID 29067083.

인간 염색체 1번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000133056 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000026447 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9144573-5] Brown RA, Ho LK, Weber-Hall SJ, Shipley JM, Fry MJ (Apr 1997). "Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K". Biochemical and Biophysical Research Communications. 233 (2): 537–44. doi:10.1006/bbrc.1997.6495. PMID 9144573.

[pmid9830063-6] Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD (Dec 1998). "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity". The Journal of Biological Chemistry. 273 (49): 33082–90. doi:10.1074/jbc.273.49.33082. PMID 9830063.

[entrez-7] "Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide".

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PIK3C2B

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