호모 사피엔스 종의 단백질 코드 유전자
GPI-앵커 트랜스아미다아제 는 사람에게서 PIGK 유전자 에 의해 코드되는 효소 이다.[5] [6]
이 유전자는 글리코실포스파티딜이노시톨(GPI)-앵커 생합성에 관여하는 시스테인단백질가수분해효소 C13의 일원을 코드한다. GPI 앵커는 많은 혈액 세포에서 발견되는 당지질이고 단백질을 세포 표면에 고정시키는 역할을 한다. 이 단백질은 다중 서브유닛 효소 GPI 트랜스아미다아제(gpi transamidase)의 멤버이며 효소 성분으로 생각됩니다. GPI 트랜스아미다아제는 완전히 조립된 GPI 단위의 단백질 [6]
상호 작용 PIGK는 PIGT [7] GPA1 과 [8] [9] 것 으로 나타났다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000142892 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000039047 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yu J, Nagarajan S, Knez JJ, Udenfriend S, Chen R, Medof ME (December 1997). "The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase" . Proc Natl Acad Sci U S A . 94 (23): 12580–5. Bibcode :1997PNAS...9412580Y . doi :10.1073/pnas.94.23.12580 PMC 25045 PMID 9356492 . ^ a b "Entrez Gene: PIGK phosphatidylinositol glycan anchor biosynthesis, class K" .^ Ohishi, Kazuhito; Nagamune Kisaburo; Maeda Yusuke; Kinoshita Taroh (April 2003). "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge" . J. Biol. Chem . United States. 278 (16): 13959–67. doi :10.1074/jbc.M300586200 ISSN 0021-9258 . PMID 12582175 . ^ Ohishi, K; Inoue N; Maeda Y; Takeda J; Riezman H; Kinoshita T (May 2000). "Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins" . Mol. Biol. Cell . UNITED STATES. 11 (5): 1523–33. doi :10.1091/mbc.11.5.1523 . ISSN 1059-1524 . PMC 14864 PMID 10793132 . ^ Vainauskas, Saulius; Maeda Yusuke; Kurniawan Henry; Kinoshita Taroh; Menon Anant K (August 2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex" . J. Biol. Chem . United States. 277 (34): 30535–42. doi :10.1074/jbc.M205402200 ISSN 0021-9258 . PMID 12052837 .
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