칼리크레인-5

KLK5
사용 가능한 구조
PDB	휴먼 유니프로트 검색: PDBe RCSB
PDB ID 코드 목록
	2PSX, 2PSY
식별자
에일리어스	KLK5, KLK-L2, KLL2, SCTE, 칼리크레인관련펩티드가수분해효소5
외부 ID	OMIM : 605643 MGI : 1915918 HomoloGene : 75000 Gene Card : KLK5
유전자 위치(인간)
크르.	19번 염색체(인간)
끝.	50,953,093 bp
유전자 위치(마우스)
크르.	7번 염색체(쥐)
끝.	43,500,605 bp
RNA발현패턴
	상단 표시 위치:
	복부 피부; ; 인간의 음경; ; 외음부; ; 잇몸; ; 정자; ; 니플; ; 소침샘; ; 식도 상피; ; 구강; ; 유즙관;
	상단 표시 위치:
	입술; ; 복부 피부; ; 등살; ; 식도; ; 배꼽; ; 표피; ; 콘딜; ; 모낭; ; 성적으로 미성숙한 생물; ; 밧세루;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 결합; 가수분해효소활성; 펩티드가수분해효소활성; 세린형펩티드가수분해효소활성; 엔도펩티드가수분해효소활성; 세린형 엔도펩티드가수분해효소활성;
셀룰러 컴포넌트	표피층체; 세포외 영역; 세포외 공간; 세포; 분비 과립;
생물학적 과정	항균펩타이드 생성의 양성 조절; G단백질결합수용체신호경로양조절; 단백질 분해; 표피 발달; 옥수수화; 세포외기질분해; 아멜로제네시스;
	출처:아미고 / QuickGO
맞춤법
	25818
	68668
	ENSG00000167754
	ENSMUSG000074155
	Q9Y337
	없음
	NM_001077491; NM_001077492; NM_012427
	NM_026806
	NP_001070959; NP_001070960; NP_036559
	없음
	위키데이터
인간 보기/편집	마우스 표시/편집

칼리크레인-5는 이전에 각질 트립틱 효소(SCTE)로 알려진 표피에서 발현되는 세린 단백질 효소이다.인간에게는 KLK5 ^[5]^[6]^[7]^[8]^[9]^[10]유전자에 의해 암호화된다.이 유전자는 19번 염색체의 클러스터에 위치한 15개의 칼리크레인 아족 중 하나이다.그 발현은 에스트로겐과 프로게스틴에 의해 상향 조절된다.대체 스플라이싱은 동일한 단백질을 ^[10]코드하는 여러 개의 전사 변형을 일으킨다.

KLK5는 각질층에서 세포 접합의 세포 외 성분을 형성하는 단백질을 분해하는 능력을 감안할 때 KLK7 및 KLK14와 함께 세포 이탈(감소)을 조절하는 것이 제안되었다.KLK7과 ^[11]KLK14를 활성화하는 것 외에 KLK5도 자체 활성화가 가능하기 때문에 이 프로세스를 규제하는 것이 좋습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000167754 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000074155 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brattsand M, Egelrud T (Nov 1999). "Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation". J Biol Chem. 274 (42): 30033–40. doi:10.1074/jbc.274.42.30033. PMID 10514489.
^ Yousef GM, Diamandis EP (Feb 2000). "The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue expression, and hormonal regulation". J Biol Chem. 274 (53): 37511–6. doi:10.1074/jbc.274.53.37511. PMID 10608802.
^ Zulkifli SN, Paine LL, Greener DL, Subramaniam R (Oct 1991). "Trends in selected obstetric complications from University Hospital, Kuala Lumpur, Malaysia". Int J Gynaecol Obstet. 35 (1): 29–36. doi:10.1016/0020-7292(91)90059-E. PMID 1680072. S2CID 46529409.
^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
^ Yamasaki K, Schauber J, Coda A, Lin H, Dorschner RA, Schechter NM, Bonnart C, Descargues P, Hovnanian A, Gallo RL (Oct 2006). "Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin". FASEB J. 20 (12): 2068–80. doi:10.1096/fj.06-6075com. PMID 17012259. S2CID 18170331.
^ ^a ^b "Entrez Gene: KLK5 kallikrein-related peptidase 5".
^ Brattsand M, Stefansson K, Lundh C, et al. (2005). "A proteolytic cascade of kallikreins in the stratum corneum". J. Invest. Dermatol. 124 (1): 198–203. doi:10.1111/j.0022-202X.2004.23547.x. PMID 15654974.

추가 정보

Li, S; Garcia, M; Gewiss, RL; Winuthayanon, W (April 2017). "Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo". PLOS Genetics. 13 (4): e1006743. doi:10.1371/journal.pgen.1006743. PMC 5411094. PMID 28414719.
Diamandis EP, Yousef GM, Luo LY, et al. (2001). "The new human kallikrein gene family: implications in carcinogenesis". Trends Endocrinol. Metab. 11 (2): 54–60. doi:10.1016/S1043-2760(99)00225-8. PMID 10675891. S2CID 25806934.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yousef GM, Luo LY, Diamandis EP (2000). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4". Anticancer Res. 19 (4B): 2843–52. PMID 10652563.
Harvey TJ, Hooper JD, Myers SA, et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". J. Biol. Chem. 275 (48): 37397–406. doi:10.1074/jbc.M004525200. PMID 10969073.
Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
Kim H, Scorilas A, Katsaros D, et al. (2001). "Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer". Br. J. Cancer. 84 (5): 643–50. doi:10.1054/bjoc.2000.1649. PMC 2363783. PMID 11237385.
Yousef GM, Scorilas A, Chang A, et al. (2002). "Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues". Prostate. 51 (2): 126–32. doi:10.1002/pros.10067. PMID 11948967. S2CID 44645840.
Yousef GM, Obiezu CV, Jung K, et al. (2003). "Differential expression of Kallikrein gene 5 in cancerous and normal testicular tissues". Urology. 60 (4): 714–8. doi:10.1016/S0090-4295(02)01811-3. PMID 12385949.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dong Y, Kaushal A, Brattsand M, et al. (2004). "Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers". Clin. Cancer Res. 9 (5): 1710–20. PMID 12738725.
Yousef GM, Kapadia C, Polymeris ME, et al. (2003). "The human kallikrein protein 5 (hK5) is enzymatically active, glycosylated and forms complexes with two protease inhibitors in ovarian cancer fluids". Biochim. Biophys. Acta. 1628 (2): 88–96. doi:10.1016/s0167-4781(03)00116-7. PMID 12890555.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Caubet C, Jonca N, Brattsand M, et al. (2004). "Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7". J. Invest. Dermatol. 122 (5): 1235–44. doi:10.1111/j.0022-202X.2004.22512.x. PMID 15140227.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ishida-Yamamoto A, Deraison C, Bonnart C, et al. (2005). "LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum". J. Invest. Dermatol. 124 (2): 360–6. doi:10.1111/j.0022-202X.2004.23583.x. PMID 15675955.

외부 링크

펩티드가수분해효소 및 그 억제제에 대한 MEROPS 온라인 데이터베이스: S01.017

인간 염색체 19번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000167754 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000074155 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10514489-5] Brattsand M, Egelrud T (Nov 1999). "Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation". J Biol Chem. 274 (42): 30033–40. doi:10.1074/jbc.274.42.30033. PMID 10514489.

[pmid10608802-6] Yousef GM, Diamandis EP (Feb 2000). "The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue expression, and hormonal regulation". J Biol Chem. 274 (53): 37511–6. doi:10.1074/jbc.274.53.37511. PMID 10608802.

[pmid1680072-7] Zulkifli SN, Paine LL, Greener DL, Subramaniam R (Oct 1991). "Trends in selected obstetric complications from University Hospital, Kuala Lumpur, Malaysia". Int J Gynaecol Obstet. 35 (1): 29–36. doi:10.1016/0020-7292(91)90059-E. PMID 1680072. S2CID 46529409.

[pmid16800723-8] Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.

[pmid17012259-9] Yamasaki K, Schauber J, Coda A, Lin H, Dorschner RA, Schechter NM, Bonnart C, Descargues P, Hovnanian A, Gallo RL (Oct 2006). "Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin". FASEB J. 20 (12): 2068–80. doi:10.1096/fj.06-6075com. PMID 17012259. S2CID 18170331.

[entrez-10] "Entrez Gene: KLK5 kallikrein-related peptidase 5".

[pmid15654974-11] Brattsand M, Stefansson K, Lundh C, et al. (2005). "A proteolytic cascade of kallikreins in the stratum corneum". J. Invest. Dermatol. 124 (1): 198–203. doi:10.1111/j.0022-202X.2004.23547.x. PMID 15654974.

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칼리크레인-5

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레퍼런스

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