호모 사피엔스 종의 단백질 코드 유전자
GAPVD1 식별자 에일리어스 GAPVD1, GAPEX5, GAPex-5, RAP6, GTP가수 분해 효소 활성화 단백질과 VPS9 영역 1. 외부 ID OMIM:611714 군사 지리 정보:1913941 HomoloGene:32637 GeneCards:GAPVD1. 유전자 위치(마우스 ) 크르. 염색체 2(마우스)[2] 밴드 2 2 B 시작 34,674,594 bp[2] 끝. 34,755,232 bp[2]
위키데이터
GTPase 활성화 단백질 및 VPS9 도메인 1(GAPVD1 , Gapex-5 및 RME-6이라고 도 함)은 GAPVD1 [5] [6] 유전자 에 의해 인체에서 코드되는 단백질 이다.
기능. GAPVD1은 아포토시스 [7] RAB5A 의 활성화에 필수적인 Rab GTPase 구아닌 뉴클레오티드 교환 인자 이다. GAPVD1은 표피 성장인자 [8] Rab5의 Gapex-5 매개 활성화는 혈장막 포스파티딜이노시톨-3-인산 의 [9]
구조. 배열 호몰로지에 근거해 포유동물 Gapex-5는 아미노말단 Ras GAP 도메인, 중심 폴리프로린(SH3 결합) 영역 및 카르복시말단 Rab GEF 도메인을 가지는 것이 확인되었다. RabGEF 도메인은 Rab5 및 [11] Rab31 을 활성화 하는[10]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000165219 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000026867 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: GAPVD1 GTPase activating protein and VPS9 domains 1" .^ Hunker CM, Galvis A, Kruk I, Giambini H, Veisaga ML, Barbieri MA (February 2006). "Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis". Biochem. Biophys. Res. Commun . 340 (3): 967–75. doi :10.1016/j.bbrc.2005.12.099 . PMID 16410077 . ^ Kitano M, Nakaya M, Nakamura T, Nagata S, Matsuda M (May 2008). "Imaging of Rab5 activity identifies essential regulators for phagosome maturation" . Nature . 453 (7192): 241–5. Bibcode :2008Natur.453..241K . doi :10.1038/nature06857 PMID 18385674 . ^ Su X, Kong C, Stahl PD (July 2007). "GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor" . J. Biol. Chem . 282 (29): 21278–84. doi :10.1074/jbc.M703725200 PMID 17545148 . ^ Lodhi IJ, Bridges D, Chiang SH, Zhang Y, Cheng A, Geletka LM, Weisman LS, Saltiel AR (July 2008). "Insulin Stimulates Phosphatidylinositol 3-Phosphate Production via the Activation of Rab5" . Mol. Biol. Cell . 19 (7): 2718–28. doi :10.1091/mbc.E08-01-0105 . PMC 2441665 PMID 18434594 . ^ Su X, Lodhi IJ, Saltiel AR, Stahl PD (September 2006). "Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5" . J. Biol. Chem . 281 (38): 27982–90. doi :10.1074/jbc.M602873200 PMID 16880210 . ^ Lodhi IJ, Chiang SH, Chang L, Vollenweider D, Watson RT, Inoue M, Pessin JE, Saltiel AR (January 2007). "Gapex-5, a Rab31 Guanine Nucleotide Exchange Factor that Regulates Glut4 Trafficking in Adipocytes" . Cell Metab . 5 (1): 59–72. doi :10.1016/j.cmet.2006.12.006 . PMC 1779820 PMID 17189207 . 추가 정보 Su X, Kong C, Stahl PD (2007). "GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor" . J. Biol. Chem . 282 (29): 21278–84. doi :10.1074/jbc.M703725200 PMID 17545148 . Hunker CM, Galvis A, Kruk I, et al. (2006). "Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis". Biochem. Biophys. Res. Commun . 340 (3): 967–75. doi :10.1016/j.bbrc.2005.12.099 . PMID 16410077 . Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol . 14 (16): 1436–50. doi :10.1016/j.cub.2004.07.051 . PMID 15324660 . S2CID 2371325 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (2): 143–50. doi :10.1093/dnares/7.2.143 PMID 10819331 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF) . Nature . 377 (6547 Suppl): 3–174. PMID 7566098 .
