호모 사피엔스 종의 단백질 코드 유전자
디펩티딜펩티드가수분해효소2 는 DPP7 [5] [6] [7] 효소 이다.
이 유전자에 의해 코드된 단백질은 정지 림프구 에서 발현되는 프롤린 후 아미노펩티드가수분해효소 이다. 이 새로운 세린단백질가수분해효소 의 억제에 의해 교란되는 상태 인 아포토시스의 억제를 통해 휴식 중인 림프구를 유지한다. 이 효소는 프롤릴 카르복시펩티다아제 와의 강한 배열 상동성을 가지며 산성 및 중성 [7]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000176978 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000026958 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Chiravuri M, Schmitz T, Yardley K, Underwood R, Dayal Y, Huber BT (Oct 1999). "A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase". J Immunol . 163 (6): 3092–9. PMID 10477574 . ^ Fukasawa KM, Fukasawa K, Higaki K, Shiina N, Ohno M, Ito S, Otogoto J, Ota N (Jan 2001). "Cloning and functional expression of rat kidney dipeptidyl peptidase II" . Biochem J . 353 (Pt 2): 283–90. doi :10.1042/0264-6021:3530283 . PMC 1221570 PMID 11139392 . ^ a b "Entrez Gene: DPP7 dipeptidyl-peptidase 7" . 추가 정보 Fornas E, Mayordomo F, Renau-Piqueras J, Alborch E (1992). "Effect of cholesterol and its autooxidation derivatives on endocytosis and dipeptidyl peptidases of aortic endothelial cells". Histol. Histopathol . 7 (2): 163–8. PMID 1515698 . Roberts VJ, Gorenstein C (1990). "The effect of antimitotic agents on the intraneuronal distribution of lysosomes". Brain Res . 521 (1–2): 62–72. doi :10.1016/0006-8993(90)91525-L . PMID 2207678 . S2CID 10381435 . Andersen KJ, McDonald JK (1989). "Lysosomal heterogeneity of dipeptidyl peptidase II active on collagen-related peptides". Ren. Physiol. Biochem . 12 (1): 32–40. doi :10.1159/000173177 . PMID 2727382 . Demuth HU, Schlenzig D, Schierhorn A, et al. (1993). "Design of (omega-N-(O-acyl)hydroxy amid) aminodicarboxylic acid pyrrolidides as potent inhibitors of proline-specific peptidases" . FEBS Lett . 320 (1): 23–7. doi :10.1016/0014-5793(93)81649-K PMID 8096464 . S2CID 24505098 . Underwood R, Chiravuri M, Lee H, et al. (1999). "Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase" . J. Biol. Chem . 274 (48): 34053–8. doi :10.1074/jbc.274.48.34053 PMID 10567372 . Chiravuri M, Agarraberes F, Mathieu SL, et al. (2000). "Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase" . J. Immunol . 165 (10): 5695–702. doi :10.4049/jimmunol.165.10.5695 PMID 11067927 . Araki H, Li Y, Yamamoto Y, et al. (2001). "Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase". J. Biochem . 129 (2): 279–88. doi :10.1093/oxfordjournals.jbchem.a002855 . PMID 11173530 . Zhan H, Yamamoto Y, Shumiya S, et al. (2002). "Peptidases play an important role in cataractogenesis: an immunohistochemical study on lenses derived from Shumiya cataract rats". Histochem. J . 33 (9–10): 511–21. doi :10.1023/A:1014943522613 . PMID 12005022 . S2CID 29588226 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Leiting B, Pryor KD, Wu JK, et al. (2003). "Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII" . Biochem. J . 371 (Pt 2): 525–32. doi :10.1042/BJ20021643 . PMC 1223300 PMID 12529175 . Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation" . Genome Res . 14 (7): 1315–23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 .
