CTDSPL

CTDSPL
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	2HL
식별자
에일리어스	CTDSPL, C3orf8, HYA22, PSR1, RBSP3, SCP3, CTD 소인산가수분해효소 등
외부 ID	OMIM : 608592 MGI : 1916524 HomoloGene : 48881 GenCard : CTDSPL
유전자 위치(인간)
크르.	3번 염색체(인간)
끝.	37,984,469 bp
유전자 위치(마우스)
크르.	9번 염색체(쥐)
끝.	118,873,066 bp
RNA발현패턴
	상단 표시 위치:
	후생 사구체; ; 니플; ; 신장수질; ; 이하선; ; 경골; ; 카디아; ; 이차 난모세포; ; 유문; ; 모낭; ; 요도;
	추가 참조 표현식 데이터
	없음
유전자 존재론
분자 함수	포스파타아제활성; 인단백인산가수분해효소활성; 가수분해효소활성; 금속 이온 결합; GO:0001948 단백질 결합; 분자 기능; RNA중합효소IICTD헵타펩타이드반복인산가수분해효소활성;
셀룰러 컴포넌트	세포외 엑소좀; 핵;
생물학적 과정	유사분열세포주기의 G1/S 전이 음성조절; 단백질인산화부정조절; 탈인산화; 단백질 탈인산화; RNA중합효소II에 의한 전사조절; 생물학적 과정;
	출처:아미고 / QuickGO
맞춤법
	10217
	69274
	ENSG00000144677
	ENSMUSG000047409
	O15194
	P58465
	NM_005808; NM_001008392
	NM_133710
	NP_001008393; NP_005799
	NP_598471
	위키데이터
인간 보기/편집	마우스 표시/편집

CTD 소인산가수분해효소 유사 단백질은 사람에게서 CTDSPL 유전자에 ^[5]^[6]^[7]의해 암호화되는 효소이다.

상호 작용

CTDSPL은 SNAI1과 ^[8]상호작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000144677 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000047409 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa S, Kai M, Tamari M, Takei Y, Takeuchi K, Bandou H, Yamane Y, Ogawa M, Nakamura Y (Aug 1997). "Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line". DNA Res. 4 (1): 35–43. doi:10.1093/dnares/4.1.35. PMID 9179494.
^ Protopopov A, Kashuba V, Zabarovska VI, Muravenko OV, Lerman MI, Klein G, Zabarovsky ER (Jan 2003). "An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies". Cancer Res. 63 (2): 404–12. PMID 12543795.
^ "Entrez Gene: CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like".
^ Wu, Yadi; Evers B Mark; Zhou Binhua P (Jan 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". J. Biol. Chem. United States. 284 (1): 640–8. doi:10.1074/jbc.M806916200. ISSN 0021-9258. PMC 2610500. PMID 19004823.

추가 정보

O'Keeffe B, Fong Y, Chen D, et al. (2000). "Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription". J. Biol. Chem. 275 (1): 279–87. doi:10.1074/jbc.275.1.279. PMID 10617616.
Kim JB, Sharp PA (2001). "Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase". J. Biol. Chem. 276 (15): 12317–23. doi:10.1074/jbc.M010908200. PMID 11145967.
Ramanathan Y, Rajpara SM, Reza SM, et al. (2001). "Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences". J. Biol. Chem. 276 (14): 10913–20. doi:10.1074/jbc.M010975200. PMID 11278802.
Zhou M, Nekhai S, Bharucha DC, et al. (2002). "TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription". J. Biol. Chem. 276 (48): 44633–40. doi:10.1074/jbc.M107466200. PMID 11572868.
Lin X, Taube R, Fujinaga K, Peterlin BM (2002). "P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA". J. Biol. Chem. 277 (19): 16873–8. doi:10.1074/jbc.M200117200. PMID 11884399.
Kim YK, Bourgeois CF, Isel C, et al. (2002). "Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation". Mol. Cell. Biol. 22 (13): 4622–37. doi:10.1128/MCB.22.13.4622-4637.2002. PMC 133925. PMID 12052871.
Yeo M, Lin PS, Dahmus ME, Gill GN (2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". J. Biol. Chem. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
Pinhero R, Liaw P, Bertens K, Yankulov K (2004). "Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II". Eur. J. Biochem. 271 (5): 1004–14. doi:10.1111/j.1432-1033.2004.04002.x. PMID 15009212.
Kashuba VI, Li J, Wang F, et al. (2004). "RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies". Proc. Natl. Acad. Sci. U.S.A. 101 (14): 4906–11. Bibcode:2004PNAS..101.4906K. doi:10.1073/pnas.0401238101. PMC 387347. PMID 15051889.

외부 링크

UCSC Genome Browser에서의 CTDSPL 인간 유전자 위치.
UCSC Genome Browser의 CTDSPL 인간 유전자 상세.

인간 염색체 3번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000144677 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000047409 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9179494-5] Ishikawa S, Kai M, Tamari M, Takei Y, Takeuchi K, Bandou H, Yamane Y, Ogawa M, Nakamura Y (Aug 1997). "Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line". DNA Res. 4 (1): 35–43. doi:10.1093/dnares/4.1.35. PMID 9179494.

[pmid12543795-6] Protopopov A, Kashuba V, Zabarovska VI, Muravenko OV, Lerman MI, Klein G, Zabarovsky ER (Jan 2003). "An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies". Cancer Res. 63 (2): 404–12. PMID 12543795.

[entrez-7] "Entrez Gene: CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like".

[pmid19004823-8] Wu, Yadi; Evers B Mark; Zhou Binhua P (Jan 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". J. Biol. Chem. United States. 284 (1): 640–8. doi:10.1074/jbc.M806916200. ISSN 0021-9258. PMC 2610500. PMID 19004823.

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CTDSPL

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상호 작용

레퍼런스

추가 정보

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