CMPK

CMPK1
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	1TEV
식별자
에일리어스	CMPK1, CK, CMK, CMPK, UMP-CMPK, UMPK, 시티딘/우리딘일인산인산화효소1
외부 ID	OMIM: 191710 MGI: 1913838 HomoloGene: 32308 GeneCard: CMPK1
EC 번호	2.7.4.6
유전자 위치(인간)
크르.	1번 염색체(인간)
끝.	47,378,839 bp
유전자 위치(마우스)
크르.	4번 염색체(쥐)
끝.	114,844,438 bp
RNA발현패턴
	상단 표시 위치:
	제주날 점막; ; 안검결막; ; 이하선; ; 십이지장; ; 직장; ; 경골; ; 구강; ; 아킬레스건; ; 랑게르한스 섬; ; 담낭;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	트랜스페라아제 활성; 뉴클레오티드 결합; 우리딜산인산화효소활성; 키나아제활성; 핵산가수분해효소함유복합인산화효소활성; 우리딘인산화효소활성; 뉴클레오시드2인산인산화효소활성; ATP 결합; 세포질산인산화효소활성; 뉴클레오시드1인산인산화효소활성;
셀룰러 컴포넌트	세포질; 세포; 세포외 엑소좀; 핵; 핵소체;
생물학적 과정	핵산염기 함유 소분자 상호 변환; 인산화; 뉴클레오시드2인산인산화; 피리미딘리보뉴클레오티드생합성법; 피리미딘뉴클레오티드생합성법; 'de novo' 피리미딘핵산염기생합성법; 뉴클레오시드3인산생합성법; 핵산가수분해효소함유복합체; 뉴클레오시드1인산인산화; UMP생합성법;
	출처:아미고 / QuickGO
맞춤법
	51727
	66588
	ENSG00000162368
	ENSMUSG000028719
	P30085
	Q9DBP5
	NM_001136140; NM_016308; NM_001366135
	NM_025647
	NP_001129612; NP_057392; NP_001353064
	NP_079923
	위키데이터
인간 보기/편집	마우스 표시/편집

UMP-CMP 인산화효소는 사람에게서 CMPK1 유전자에 ^[5]^[6]의해 암호화되는 효소이다.

기능.

우리딘1인산(UMP)/시티딘1인산(CMP) 키나아제(EC 2.7.4.4)는 ATP에서 UMP, CMP 및 디옥시-CMP(dCMP)로의 포스포릴 전달을 촉매하여 ADP 및 이에 대응하는 뉴클레오시드2인산을 형성한다.이러한 뉴클레오시드 디포스페이트는 세포 핵산 ^[6]^[7]합성에 필요하다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000162368 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000028719 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Van Rompay AR, Johansson M, Karlsson A (1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme". Molecular Pharmacology. 56 (3): 562–9. doi:10.1124/mol.56.3.562. PMID 10462544.
^ ^a ^b 엔트레스진 51727
^ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research. 62 (6): 1624–31. PMID 11912132.

외부 링크

UCSC Genome Browser의 인간 CMPK1 게놈 위치 및 CMPK1 유전자 상세 페이지.

추가 정보

Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (1992). "Human liver protein map: A reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669. S2CID 23518983.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hughes GJ, Frutiger S, Paquet N, Pasquali C, Sanchez JC, Tissot JD, Bairoch A, Appel RD, Hochstrasser DF (1993). "Human liver protein map: Update 1993". Electrophoresis. 14 (11): 1216–22. doi:10.1002/elps.11501401181. PMID 8313870. S2CID 33424554.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Pearman AT, Castro-Faria-Neto HC, McIntyre TM, Prescott SM, Stafforini DM (2001). "Characterization of human UMP-CMP kinase enzymatic activity and 5′ untranslated region". Life Sciences. 69 (20): 2361–70. doi:10.1016/S0024-3205(01)01322-4. PMID 11681623.
Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research. 62 (6): 1624–31. PMID 11912132.
Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D (2003). "Reaction of human UMP-CMP kinase with natural and analog substrates". European Journal of Biochemistry. 270 (8): 1784–90. doi:10.1046/j.1432-1033.2003.03537.x. PMID 12694191.
Segura-Peña D, Sekulic N, Ort S, Konrad M, Lavie A (2004). "Substrate-induced Conformational Changes in Human UMP/CMP Kinase". Journal of Biological Chemistry. 279 (32): 33882–9. doi:10.1074/jbc.M401989200. PMID 15163660.
Hsu CH, Liou JY, Dutschman GE, Cheng YC (2004). "Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase is Differentially Regulated by ATP and Magnesium". Molecular Pharmacology. 67 (3): 806–14. doi:10.1124/mol.104.006098. PMID 15550676. S2CID 579635.
Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah NG (2005). "Beta-Amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin". Journal of Neurochemistry. 92 (1): 93–102. doi:10.1111/j.1471-4159.2004.02840.x. PMID 15606899.
Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D (2007). "Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives – a screening based on affinity for the UMP-CMP binding site". FEBS Journal. 274 (14): 3704–14. doi:10.1111/j.1742-4658.2007.05902.x. PMID 17608725.
Gagyi C, Bucurenci N, Sîrbu O, Labesse G, Ionescu M, Ofiteru A, Assairi L, Landais S, Danchin A, Bârzu O, Gilles AM (2003). "UMP kinase from the Gram-positive bacterium Bacillus subtilis is strongly dependent on GTP for optimal activity". European Journal of Biochemistry. 270 (15): 3196–204. doi:10.1046/j.1432-1033.2003.03702.x. PMID 12869195.
Ofiteru A, Bucurenci N, Alexov E, Bertrand T, Briozzo P, Munier-Lehmann H, Gilles AM (2007). "Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase". The FEBS Journal. 274 (13): 3363–73. doi:10.1111/j.1742-4658.2007.05870.x. PMID 17542990. S2CID 2394831.

인간 염색체 1번 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000162368 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000028719 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10462544-5] Van Rompay AR, Johansson M, Karlsson A (1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme". Molecular Pharmacology. 56 (3): 562–9. doi:10.1124/mol.56.3.562. PMID 10462544.

[entrez-6] 엔트레스진 51727

[7] Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research. 62 (6): 1624–31. PMID 11912132.

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CMPK

네임스페이스

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목차

기능.

레퍼런스

외부 링크

추가 정보