할로시딘

Halocidin
할로시딘
Halocidin.png
식별자
3D 모델(JSmol)
첸블
  • InChI=1S/C155H251N47O38S2/c1-73(2)41-100(181-121(206)63-170-134(217)109(51-91-59-163-172-91)190-1461-1653-691)(235)197-102(43-75(5)6)136(219)179-88(27)154(237)238)67-241-242-68-117(151(234)178-86(25)129(212)184-99(38-32-34-40-157)133(216)169-66-124(209)202-126(83(21)22)153(236)198-103(44-76(7)8)137(220)180-89(28)155(239)240)200-149(232)115(57-120(162)205)196-140(223)101(42-74(3)4)182-122(207)64-171-135(218)110(52-92-60-164-70-173-92)191-147(230)112(54-94-62-166-72-175-94)193-145(228)108(49-81(17)18)189-142(225)105(46)186-130(213)87(26)178(26)113(55-118(160203)194-3(2679)1047)65,174)(H,166,175)(H,168,215)(H,169,216)(H,170,217)(H,176,221)(H,177,233)(H,178,234)(H,179,219,220),202,209) (H,237,238) (H,239,240)
    키: WONTRCIUWDITXFQ-UHFFFAOYSA-N
  • CC(C)CC(=O)NC(CC(=O)N)C(=O)NC(CSSCC(=O)NC(C)C(=O)NC(=O)NC(=C)NC(=O)NC(C)NC(=O)NC(NC)NC(=O)C(CC(=O)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(CC1=CN=CN1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC(C)C)NC(=O)C(=O)NC(=O)C(CC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC3=CNC4=CC=CC=C43)N)C(=O)NC(C(=O)NC(CCCN)C(=O)C(=OC)C(=O)C(NC)C(NC)C(=O)NC)NC(NC(NC)C)C)C(=NC)NC)NC(=O)CNC(=O)C(CC5=CN=CN5)NC(=O)C(CC6=CN=CN6)NC(=O)C(=O)C(CC(C)C)NC(=O)C(C)N
달리 명시되지 않은 한 표준 상태(25°C[77°F], 100kPa)의 재료에 대한 데이터가 제공됩니다.

할로시딘은 튜니케이트의 [1][2]할로신티아 오란티움 종에서 분리된 항균성 펩타이드이다.마우스 모델에서 유도체 펩타이드는 구강세정제 [3]첨가물로 사용될 때 곰팡이 내성 칸디다 알바칸스 치료에 효과를 보였다.

레퍼런스

  1. ^ Jang WS, Kim KN, Lee YS, Nam MH, Lee IH (June 2002). "Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium". FEBS Letters. 521 (1–3): 81–6. doi:10.1016/s0014-5793(02)02827-2. PMID 12067731. S2CID 45780988.
  2. ^ Jang WS, Lee SC, Lee YS, Shin YP, Shin KH, Sung BH, et al. (November 2007). "Antimicrobial effect of halocidin-derived peptide in a mouse model of Listeria infection". Antimicrobial Agents and Chemotherapy. 51 (11): 4148–4156. doi:10.1128/AAC.00635-07. PMC 2151467. PMID 17846130.
  3. ^ Shin SH, Lee YS, Shin YP, Kim B, Kim MH, Chang HR, et al. (May 2013). "Therapeutic efficacy of halocidin-derived peptide HG1 in a mouse model of Candida albicans oral infection". The Journal of Antimicrobial Chemotherapy. 68 (5): 1152–1160. doi:10.1093/jac/dks513. PMID 23302580.
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